Protein Alignment ATP8B and atp8b3

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_003201102.3
• Gene: atp8b3 / 566530
• ZFINID: ZDB-GENE-050208-424
• Length: 1174
• Species: Danio rerio
• Alignment Length: 1540
• Identity: 495/1540 - (32%)
• Similarity: 718/1540 - (46%)
• Gaps: 421/1540 - (27%)

  Fly   164 VTSESKSVPSLRRLSQIRRRRSSYYF------SEN--ERRIRANDKEFNAQF-----------KY 209
            :.:|.||          :..:|..||      :||  :..:|||.::|:...           :|
Zfish     4 IATEDKS----------KTEQSVQYFIMTGSTTENGIKWEVRANGRDFHQSCRRRSVLCIRWGRY 58

  Fly   210 HNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAV 274
            .:|.:::.||:..||.|.||.|||||.||.:||.:::||.:|.|:::...||.:||:.||.:...
Zfish    59 ADNVVRSYKYTPLTFFPLNLYEQFQRAANLFFLLIVILQCVPVIATIPWYTTMLPLLIVLFVRGC 123

  Fly   275 KDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNG 339
            ||...|:.|..||:|:|.|....|........||.:|.|||::|:..:|.:.||.|||.::||..
Zfish   124 KDLATDVGRRRSDAQINRRPCDILTPEGFKTVKWKDVCVGDILRVHKDQVIPADLLLLCSTEPYS 188

  Fly   340 LCFIETAELDGETNLKAKQCLTET-IEL-GD-RHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ 401
            ||::|||::|||||||.:|.||.| .|| || ...:|..|:..:.||.||..|:.|.|...|:|:
Zfish   189 LCYVETADIDGETNLKFRQALTVTHTELNGDSTEQNLAAFDAIVRCEEPNGNLHSFRGEFHWKGE 253

  Fly   402 RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLV 466
            |..|..:.:||||.|||||.:.||:.::.|.|:|::||.|:.:.|.|.|:.|||..::.|:||::
Zfish   254 RHLLGTDHLLLRGTVLRNTDYAYGLTIYTGSDSKILQNCGRLKLKKTHVEILLNKTVLVILLFML 318

  Fly   467 SICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYV 531
            :...|.|||..|:|..|..::.:.    .|:.:|..|   ...|.|.|:.|.|:|:..:|:|||:
Zfish   319 TTALLLAIGAGIFEYRISPNYDVV----SIVQRDSSP---AYQGFLTFWGYIILLSPSMPMSLYI 376

  Fly   532 SVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSI 596
            :.|||..|...||.||.|||:..||..|.||||||||||||:.::.||||||||||.:.|.:|.|
Zfish   377 TFEVIHMVHCLLIGWDVEMYWEDTNCPAHARTTTLNEELGQVGHLLSDKTGTLTQNRLLFRQCFI 441

  Fly   597 NGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKT 661
            .|..||
Zfish   442 AGHIYG----------------------------------------------------------- 447

  Fly   662 SMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGG 726
                               ||.:.:.|:|.|..|.....:::|..         ||..:|.|.|.
Zfish   448 -------------------DISQKSKPLDLSWNRFSCGGLKFSDQ---------RLVDKLRGRGS 484

  Fly   727 LSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIR 791
            |.                    |.:
Zfish   485 LE--------------------CQE---------------------------------------- 489

  Fly   792 FKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSA 856
                                                                             
Zfish   490 ----------------------------------------------------------------- 489

  Fly   857 NPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAAR 921
                                        ||..||||||||:|..||...|||.||||.|||.|||
Zfish   490 ----------------------------FFTALALCHTVMSEWKDGLPHYQAASPDEEALVCAAR 526

  Fly   922 NFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYDR 985
            ..|:||.:||.:::||..||.|..|:||.:|||.:.|:||||::|. |..:.||.||||.||.:|
Zfish   527 ELGWVFLSRTRDTLTISEMGLTRNYQLLALLDFTSKRRRMSVLVRSPGGQLKLYSKGADIVILER 591

  Fly   986 LHGGQED--LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAI 1048
            |   |:|  |:..|...|..||...||||.:|.|.:.|..:.:|......|..:..::|..|..|
Zfish   592 L---QKDWPLQESTDRALELFAQSCLRTLCVAVRPVPEALWTEWSRALNLAGTATGNQETLLEEI 653

  Fly  1049 YEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELAD 1113
            |:::|.::.|:|||||||:||:|||::||:|:.||:|:|||||||.|||:|:||:|:|:.   .|
Zfish   654 YDQMEKDLMLLGVTAIEDRLQEGVPETIASLRRAGVKVWVLTGDKTETAVNVGYACKLMD---PD 715

  Fly  1114 VFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNL 1178
            ..::.|       ::|||..||        |..       |.|.......|.:|...|.|.:..|
Zfish   716 TTLIQG-------EELRQLLES--------PSP-------NVDVKSKEPEVWITDKKAVMSKAAL 758

  Fly  1179 PPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNG 1243
                       |::            ||:.||..      |.||.|.
Zfish   759 -----------VIS------------GPELAELT------KSSEWGA------------------ 776

  Fly  1244 HSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKA 1308
                         ||:.::.||::|:||||||.|||.|||::::...::|:|||||||||:|||.
Zfish   777 -------------KFVALSGQCQSVLCCRVTPAQKAEVVEMVRKHSASITMAIGDGANDVNMIKT 828

  Fly  1309 AHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWY 1373
            ||||||:.|.||.||||::|:::|||.:|.:||||||.|||||:...||||.||..||.|.|.||
Zfish   829 AHIGVGLCGVEGSQAVLNADFALAQFSFLRKLLLVHGHWSYYRISILLRYFLYKTTAFALVHTWY 893

  Fly  1374 SLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREF 1438
            |.:.|||||.:::..:||::...|||||:...|:||||:|.::.|.:|.:|:.|.|.:|||....
Zfish   894 SFYNGFSAQPMYESWYISLFTTTYTSLPIQCTGIFEQDISARSCLCWPEIYSIGQKKQLFNPSVL 958

  Fly  1439 IYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVV 1503
            ..::|:..::|::.|.:|.|:.:       :...|..||...:.|.::...|.::.|.|.|||..
Zfish   959 ASTLLYSFYSSIIFFFVPMGILQ-------YSALDFQTLAITIETSVLFATTLEVILCTKYWTKW 1016

  Fly  1504 NHVTIWGSLVWYFV---------------LDYFYNYVIGGPYVGSLTQAMKDLTFWVTMLITVMA 1553
            |...:..||..:|:               .|||        ::|:...|......|:|:.:|...
Zfish  1017 NVAAVIFSLAAFFLSTLALHSTRLFTASPKDYF--------FLGASQNAYSTPEVWLTIFVTTCV 1073

  Fly  1554 LVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFG 1618
            .|.|.:..:        :|...:...:..||||.|:..|...:..:||....||.||.:..:|||
Zfish  1074 AVLPSITTR--------ALGVVLANPNKHKIHSSANEPVELQSWFQRGTVQRRSSYAVSQGKGFG 1130

  Fly  1619 RLITSGKIMHKLPQDFAFPL--------GLGTKKTQVLHNNLNSA 1655
            :|||:|.   .||.  |.|.        .|..:..|.||..:|.|
Zfish  1131 KLITTGV---GLPS--AAPRQDGRVTAESLKNESPQGLHIEMNRA 1170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	171/393 (44%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	239/573 (42%)
atp8b3	XP_003201102.3	None