Protein Alignment ATP8B and atp10b

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_017214606.1
• Gene: atp10b / 563932
• ZFINID: ZDB-GENE-130530-796
• Length: 1294
• Species: Danio rerio
• Alignment Length: 1463
• Identity: 460/1463 - (31%)
• Similarity: 729/1463 - (49%)
• Gaps: 278/1463 - (19%)

  Fly   180 IRRRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCL 244
            ||:..|:..|.:..:|.:.|.       :|..|.|||:||.|::|||.||.|||.||||.||:.|
Zfish    24 IRKVVSNLPFEDLRKREQPNR-------QYEGNAIKTNKYRLWSFLPMNLFEQFHRLANIYFVGL 81

  Fly   245 LVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKL--VEAK 307
            .:|..||.:::..|....||:..:|.||||||.::|.:|:.:|.|:||......|...:  ||.:
Zfish    82 AILNFIPVVNAFQPEVALIPICIILALTAVKDGWEDFRRYQTDQQLNNMPCFIFRRRLMCFVERR 146

  Fly   308 WSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDS 372
            |.:|:|||.:::.:|:.:.||.|||.||:|||:|.:|||.||||||||.::.:.....||:....
Zfish   147 WKDVRVGDFVKVLSNEIIPADILLLHTSDPNGVCHMETANLDGETNLKQRKVVPGFSTLGEPFQP 211

  Fly   373 LWNFNGEIICERPNNLLNKFDGTLIWRGQR---FALDNEKILLRGCVLRNTQWCYGVVVFAGVDT 434
             ..|:..::||.|||.||.|.|.:....:|   |.:|:  :|||||.:|||....|:||:||.:|
Zfish   212 -QTFDSTVVCENPNNNLNLFKGFIERPDKRRSGFGIDS--LLLRGCTVRNTDDAAGIVVYAGHET 273

  Fly   435 KLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPK 499
            |.|.|:...::|.:.::|.:|..::..||.|..:|.:.|:|.|||......     :| .:|:|.
Zfish   274 KSMLNNNGPRYKRSKIERKMNTDVLFCVLLLFFMCLIGALGHAIWLETFST-----MP-SYIVPD 332

  Fly   500 ---DYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKA 561
               :||  .:.:.|..:||:..|:|..::|:|||||:|:::..|.|.|..|.|:|....::..:.
Zfish   333 SNGNYI--SSALAGFYMFFTMIILLQVMIPVSLYVSIELVKMGQIFFITQDAELYDQELDSRVQC 395

  Fly   562 RTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEIT------EQQT 620
            |...:.|:||||||:|||||||||:|.|.|.:|:|.|..|  ..:.....|..|.      |:.|
Zfish   396 RALNITEDLGQIQYVFSDKTGTLTENKMVFKRCTIMGTEY--CHEENAARLAVINGGGNEEEEVT 458

  Fly   621 IFQNSNTNNRPSPLSGAIVAPPAAPPPIILV------HKAEVHAKKTSMVVTSSGEAQVLPDRPR 679
            |:|.:..                  ||:..:      |....:...|.:...|...::|... .:
Zfish   459 IYQKTKL------------------PPLFPLEELQDDHTGHKNHANTQVAAASRRRSKVAAG-AQ 504

  Fly   680 SDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGG--- 741
            ||:..|:|          |:.|  ..|.|.                 |...|.::...|..|
Zfish   505 SDMAFSSP----------LETV--VVPDRK-----------------LMLEVDHQMASIQTGPYL 540

  Fly   742 -FKRSGAGCMQRQLSR-TSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKI----------RFKK 794
             |..:.|.|....:|. |:...:||...:|..:.:     ||||..:..||          |||:
Zfish   541 DFFLALAICNTVVVSTLTAQRQRVKGRRNSSYSGS-----SSHNMGQWFKISSLQKFFSSMRFKR 600

  Fly   795 APSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPH 859
            ...|......|       ||:...|..:|:........|..::...
Zfish   601 NRETMADPFAI-------DEDEPDTFHISSVSDSRPGQKVISSEGK------------------- 639

  Fly   860 HESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFG 924
                    |:..|.  ||:|           :|             |:|.|||||||:.||:.:|
Zfish   640 --------DKRSLS--RSEE-----------VC-------------YEAHSPDEAALIHAAKAYG 670

  Fly   925 FVFRTRTPNSITIEVMGQT-EEYELLNILDFNNVRKRMSVILR--RGDSMVLYCKGADNVIYDRL 986
            |....|||..:|:::..:| .::|:|::|.|::.|:|||:|:|  ..:.:::|.||||:.:.::|
Zfish   671 FTMVERTPRYVTVKLPNETLLKFEVLDVLTFDSTRRRMSIIVRHPHTNEIIMYTKGADSAVMEKL 735

  Fly   987 ------HGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL 1045
                  ....:.:..|||..|:.:|.:|||||..|::.::||.:..|.:.:|||..::|.:|::|
Zfish   736 GNVFSVESAAKRIAVRTQKDLDMYARDGLRTLCFAKKVISEQEFKAWFTSRQEALSAIDEKEERL 800

  Fly  1046 NAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLT-D 1109
            .....:||:.:.|:|.|.|||:||:.||::|..|:.||:::|||||||.|||:||.|||:||. :
Zfish   801 METANDIENNLTLLGATGIEDRLQENVPETIQALRRAGMQVWVLTGDKPETAVNIAYSCKLLDHE 865

  Fly  1110 ELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPG-GFDP-FDRLNSDSNMDPLSVTMTQTSAF 1172
            :|...|..:..||.::     :.::::....|...| |.|| |...||           |.|...
Zfish   866 DLVFTFTTNKKSVCKM-----RLEDTLSEVRRTWGGLGLDPQFRGYNS-----------TFTGPL 914

  Fly  1173 MQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGF 1237
            |:           |:|
Zfish   915 ME-----------PSI------------------------------------------------- 919

  Fly  1238 ALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGAND 1302
            .||::|.:|...||.:|..:|:::...|:||:|||||||||:.||::|::....:|||:||||||
Zfish   920 GLVIDGPTLNMALSEDLVEQFVELCKHCRAVLCCRVTPLQKSSVVKVIRQKLRVMTLAVGDGAND 984

  Fly  1303 VSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFT 1367
            |:||:||.:|:|:|||||:|||::||::|.:|::|:|||||||.|.|.|:...:.||||||.|:.
Zfish   985 VNMIQAADVGIGVSGQEGMQAVMASDFAITRFKHLQRLLLVHGHWCYSRLANMVIYFFYKNVAYV 1049

  Fly  1368 LCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSEL 1432
            ....||..|||||...:.|...:..:|||:||.|.:..|:.:::|||...|..|.||..|..||.
Zfish  1050 NLLFWYQFFCGFSGTAMIDYWLMIFFNLFFTSAPPIMFGIMDKEVSDSTLLSLPELYRRGQHSEG 1114

  Fly  1433 FNIREFIYSVLHGAFTSLVLFLIPYGVYKD---GVSANGFVVSDHMTLGAVVATILIVDNTAQIS 1494
            :....|..::|...:.|||.|.|||..|.|   |:          .:.|..:.|:.:......::
Zfish  1115 YRRSTFWIAILDAFYQSLVCFFIPYWTYNDSDIGI----------FSFGTPMNTVSLFTIILHLA 1169

  Fly  1495 LYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVI------GGPYVGSLTQAMKDLTFWVTMLITVMA 1553
            :....||||:.|.:.||::.||:|...|:.:.      ..|| ..:.:.|.|..|::..::|.:.
Zfish  1170 IEIKSWTVVHWVIMVGSVLVYFILTLAYSAICISCNPPSDPY-WIMHKQMADPMFYLVCVLTTVV 1233

  Fly  1554 LVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHS 1586
            .:.|....:.....:.|||  .:|.:.|:::.|
Zfish  1234 ALLPRYTLRVLKGTLAPSL--HLRARQLERLPS 1264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	162/398 (41%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	205/582 (35%)
atp10b	XP_017214606.1	P-type_ATPase_APLT_Dnf-like	48..1138	CDD:319770	421/1291 (33%)
		Haloacid Dehalogenase-like Hydrolases	<387..>500	CDD:473868	35/132 (27%)