Protein Alignment ATP8B and atp11a

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_021332758.1
• Gene: atp11a / 562925
• ZFINID: ZDB-GENE-090311-52
• Length: 1212
• Species: Danio rerio
• Alignment Length: 1470
• Identity: 388/1470 - (26%)
• Similarity: 641/1470 - (43%)
• Gaps: 421/1470 - (28%)

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTL 271
            ::.:|.|.:|||:.:.|:|.||.|||:|:||||||.:.::|||  |.:.| |:|:.:||..|:|:
Zfish    44 RFPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLI--IDTPTSPMTSGLPLFFVITV 106

  Fly   272 TAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            ||:|..|:|..||.:|:.||......:::||:|..:..:::|||::::..|:....|.:|||||.
Zfish   107 TAIKQGYEDWIRHKADNSVNQCPVHIVQHGKVVRKQSQKLRVGDIVQVKENETFPCDLILLSTSR 171

  Fly   337 PNGLCFIETAELDGETNLKAKQCL--TETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL--- 396
            .:|.||:.||.||||::.|....:  |:.....:..|:|   :..|.||:|...|.||.|.:
Zfish   172 EDGTCFVTTASLDGESSHKTYYAVQDTKAFSTAEEVDTL---HATIECEQPQPDLYKFVGRINIY 233

  Fly   397 IWRGQRFA--LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIII 459
            :.|.:..|  |.:|.:||||..|:||::.:.|.::.|::||:..|......|.:.|::.:|..:|
Zfish   234 LDRDEPIARPLGSENLLLRGATLKNTEYIHAVAIYTGMETKMALNYQSKSQKRSAVEKSMNAYLI 298

  Fly   460 GIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPW----------EHIIPKDYIPTGATVIGLLVF 514
            ..:..|:|...:..:...:|:....:.    .||          .|::.:.:..          |
Zfish   299 VYLCILISKALINTVLKYVWQADPNRD----EPWYNQRTESERQRHVLIRAFTD----------F 349

  Fly   515 FSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSD 579
            .::.::.|.::|:|:||:||:.:|:.|:.|.||::|:...........|:.|||||||::|:|:|
Zfish   350 LAFMVLFNYIIPVSMYVTVEMQKFLGSYFILWDDDMFDEEVGERPLVNTSDLNEELGQVEYVFTD 414

  Fly   580 KTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAA 644
            ||||||:|.|...:|.::|..|                                          .
Zfish   415 KTGTLTENNMELRECCVDGHVY------------------------------------------V 437

  Fly   645 PPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRS 709
            |..|.                    ..|:||         .|..||..:..||::
Zfish   438 PHAIC--------------------NGQILP---------GAAGMDMIDSSPGVE---------- 463

  Fly   710 QDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTET 774
                                                                             
Zfish   464 ----------------------------------------------------------------- 463

  Fly   775 HNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW 839
                                                                             
Zfish   464 ----------------------------------------------------------------- 463

  Fly   840 SSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA---ETVD 901
                                                  .:|...:|||.|.|||||..   ||||
Zfish   464 --------------------------------------GKEREELFFRALCLCHTVQVKEEETVD 490

  Fly   902 GKLE----------YQAQSPDEAALVSAARNFGFVF-RTRTPNSITIEVMGQTEEYELLNILDFN 955
            |...          |.:.||||.|||...:..||.: |.:..:...:....:.|.:|||::|:|:
Zfish   491 GIKRGIHQGKATSFYISSSPDEVALVEGMKRLGFTYLRLKDSHMEILNREDEMERFELLDVLNFD 555

  Fly   956 NVRKRMSVILR-RGDSMVLYCKGADNVIYDRLHGGQ-EDLKARTQDHLNKFAGEGLRTLALAERR 1018
            :||:|||||:| ......|:|||||:.::.|:..|: |.::||.:.:    |.||||||.:|.:|
Zfish   556 SVRRRMSVIVRSNSGEYYLFCKGADSSVFPRVVSGKVEQVRARVEHN----AVEGLRTLCVAYKR 616

  Fly  1019 LTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAG 1083
            |:::.|.:.......|.|::..|::||...|:.||.:..|:|.||:||:|||....:|.:|..||
Zfish   617 LSQEEYEETCRLLTSAKLALQERDKKLAEAYDVIEKDFILLGATAVEDRLQDKAADTIESLHKAG 681

  Fly  1084 IKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFD 1148
            ||:|||||||.|||....|:.                                |:::|
Zfish   682 IKVWVLTGDKMETAAATCYAS--------------------------------KLFHR------- 707

  Fly  1149 PFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNN 1213
                     |...|.:|..:|    :|.:|..          |.|                :.:.
Zfish   708 ---------NTQILELTTKRT----EEQSLHD----------VLF----------------DLSR 733

  Fly  1214 LFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSP---------ELENKFLDIASQCKAVI 1269
            ....:.||....|.|.:..:...:.|:::|.:|...|.|         ..:..||:|...|.||:
Zfish   734 TVLRQHGSMTRDTFSGLSGDYQDYGLIIDGATLSAVLKPTQDATSNSGNYKEIFLEICRNCSAVL 798

  Fly  1270 CCRVTPLQKALVVELIKRAK-NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQ 1333
            |||:.|||||.:|:|||.:| :.:||||||||||||||..||:|:||.|:||.||..:|||:|.:
Zfish   799 CCRMAPLQKAQIVKLIKASKEHPITLAIGDGANDVSMILEAHVGIGIMGKEGRQAARNSDYAITK 863

  Fly  1334 FRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYT 1398
            |::|:::|||||.:.|.|:.:.::||||||..|......|..|||||.|.::|..::::||:.:|
Zfish   864 FKHLKKMLLVHGHYYYIRIAELVQYFFYKNVCFIFPQFLYQFFCGFSQQPLYDTAYLTLYNISFT 928

  Fly  1399 SLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDG 1463
            |||:|...:.||.::.......|.||....|:.|.....|||....|.|.::|.|...:.::.:.
Zfish   929 SLPILLYSLMEQHINMDILKRDPSLYRDIAKNSLLTWPTFIYWTFLGVFDAVVFFFGAFFLFDNT 993

  Fly  1464 V-SANGFVVS-------DHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDY 1520
            . ::||.:::       .:.|.|.:|.|:|:...|.:::|.|.|||.:||..|||||::|.:...
Zfish   994 TFTSNGQLMATNTQMMFGNWTFGTLVFTVLVFTVTLKLALDTHYWTWINHFVIWGSLLFYVIFSL 1058

  Fly  1521 FYNYVIGGPYVG------SLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQ- 1578
            .:..:| .|::.      ...|.:.....|:::::.::..:.|.:..|.....:.|:.:::|:.
Zfish  1059 LWGGII-WPFLNYQRMYYVFMQMLSSGPAWLSIILLIIVSLLPDVLKKVLCRALWPTTTERIQNA 1122

  Fly  1579 -----------KSLKKIHSRASSDVRRTASSRRGRRSVRS 1607
                       ..|..:|:..:....|..:.|:.....||
Zfish  1123 DKLYKGHLSEFSPLTSLHAPPARKHERRGNERQNHAHRRS 1162

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	135/408 (33%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	206/596 (35%)
atp11a	XP_021332758.1	P-type_ATPase_APLT_Dnf-like	47..977	CDD:319770	350/1279 (27%)
		PhoLip_ATPase_C	854..1114	CDD:465071	76/260 (29%)