DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and atp11a

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_005171058.2	Gene:	atp11a / 562925	ZFINID:	ZDB-GENE-090311-52	Length:	1212	Species:	Danio rerio

Alignment Length:	1464	Identity:	389/1464 - (26%)
Similarity:	641/1464 - (43%)	Gaps:	420/1464 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTL 271
            ::.:|.|.:|||:.:.|:|.||.|||:|:||||||.:.::|||  |.:.| |:|:.:||..|:|:
Zfish    44 RFPDNRIVSSKYTFWNFIPKNLFEQFRRIANFYFLIIFLVQLI--IDTPTSPMTSGLPLFFVITV 106

  Fly   272 TAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            ||:|..|:|..||.:|:.||......:::||:|..:..:::|||::::..|:....|.:|||||.
Zfish   107 TAIKQGYEDWIRHKADNSVNQCPVHIVQHGKVVRKQSQKLRVGDIVQVKENETFPCDLILLSTSR 171

  Fly   337 PNGLCFIETAELDGETNLKAKQCL--TETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL--- 396
            .:|.||:.||.||||::.|....:  |:.....:..|:|   :..|.||:|...|.||.|.:
Zfish   172 EDGTCFVTTASLDGESSHKTYYAVQDTKAFSTAEEVDTL---HATIECEQPQPDLYKFVGRINIY 233

  Fly   397 IWRGQRFA--LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIII 459
            :.|.:..|  |.:|.:||||..|:||::.:.|.::.|::||:..|......|.:.|::.:|..:|
Zfish   234 LDRDEPIARPLGSENLLLRGATLKNTEYIHAVAIYTGMETKMALNYQSKSQKRSAVEKSMNAYLI 298

  Fly   460 GIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPW----------EHIIPKDYIPTGATVIGLLVF 514
            ..:..|:|...:..:...:|:....:.    .||          .|::.:.:..          |
Zfish   299 VYLCILISKALINTVLKYVWQADPNRD----EPWYNQRTESERQRHVLIRAFTD----------F 349

  Fly   515 FSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSD 579
            .::.::.|.::|:|:||:||:.:|:.|:.|.||::|:...........|:.|||||||::|:|:|
Zfish   350 LAFMVLFNYIIPVSMYVTVEMQKFLGSYFILWDDDMFDEEVGERPLVNTSDLNEELGQVEYVFTD 414

  Fly   580 KTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAA 644
            ||||||:|.|...:|.::|..|                                          .
Zfish   415 KTGTLTENNMELRECCVDGHVY------------------------------------------V 437

  Fly   645 PPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRS 709
            |..|.                    ..|:||         .|..||..:..||::
Zfish   438 PHAIC--------------------NGQILP---------GAAGMDMIDSSPGVE---------- 463

  Fly   710 QDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTET 774

Zfish   464 ----------------------------------------------------------------- 463

  Fly   775 HNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW 839

Zfish   464 ----------------------------------------------------------------- 463

  Fly   840 SSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA---ETVD 901
                                                  .:|...:|||.|.|||||..   ||||
Zfish   464 --------------------------------------GKEREELFFRALCLCHTVQVKEEETVD 490

  Fly   902 GKLE----------YQAQSPDEAALVSAARNFGFVF-RTRTPNSITIEVMGQTEEYELLNILDFN 955
            |...          |.:.||||.|||...:..||.: |.:..:...:....:.|.:|||::|:|:
Zfish   491 GIKRGIHQGKATSFYISSSPDEVALVEGMKRLGFTYLRLKDSHMEILNREDEMERFELLDVLNFD 555

  Fly   956 NVRKRMSVILR-RGDSMVLYCKGADNVIYDRLHGGQ-EDLKARTQDHLNKFAGEGLRTLALAERR 1018
            :||:|||||:| ......|:|||||:.::.|:..|: |.::||.:.:    |.||||||.:|.:|
Zfish   556 SVRRRMSVIVRSNSGEYYLFCKGADSSVFPRVVSGKVEQVRARVEHN----AVEGLRTLCVAYKR 616

  Fly  1019 LTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAG 1083
            |:::.|.:.......|.|::..|::||...|:.||.:..|:|.||:||:|||....:|.:|..||
Zfish   617 LSQEEYEETCRLLTSAKLALQERDKKLAEAYDVIEKDFILLGATAVEDRLQDKAADTIESLHKAG 681

  Fly  1084 IKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFD 1148
            ||:|||||||.|||....|:.                                |:::|
Zfish   682 IKVWVLTGDKMETAAATCYAS--------------------------------KLFHR------- 707

  Fly  1149 PFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNN 1213
                     |...|.:|..:|    :|.:|..          |.|                :.:.
Zfish   708 ---------NTQILELTTKRT----EEQSLHD----------VLF----------------DLSR 733

  Fly  1214 LFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSP---------ELENKFLDIASQCKAVI 1269
            ....:.||....|.|.:..:...:.|:::|.:|...|.|         ..:..||:|...|.||:
Zfish   734 TVLRQHGSMTRDTFSGLSGDYQDYGLIIDGATLSAVLKPTQDATSNGGNYKEIFLEICRNCSAVL 798

  Fly  1270 CCRVTPLQKALVVELIKRAK-NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQ 1333
            |||:.|||||.:|:|||.:| :.:||||||||||||||..||:|:||.|:||.||..:|||:|.:
Zfish   799 CCRMAPLQKAQIVKLIKASKEHPITLAIGDGANDVSMILEAHVGIGIMGKEGRQAARNSDYAITK 863

  Fly  1334 FRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYT 1398
            |::|:::|||||.:.|.|:.:.::||||||..|......|..|||||.|.::|..::::||:.:|
Zfish   864 FKHLKKMLLVHGHYYYIRIAELVQYFFYKNVCFIFPQFLYQFFCGFSQQPLYDTAYLTLYNISFT 928

  Fly  1399 SLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDG 1463
            |||:|...:.||.::.......|.||....|:.|.....|||....|.|.::|.|...:.::.:.
Zfish   929 SLPILLYSLMEQHINMDILKRDPSLYRDIAKNSLLTWPTFIYWTFLGVFDAVVFFFGAFFLFDNT 993

  Fly  1464 V-SANGFVVS-------DHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDY 1520
            . ::||.:::       .:.|.|.:|.|:|:...|.:::|.|.|||.:||..|||||::|.:...
Zfish   994 TFTSNGQLMATNTQMMFGNWTFGTLVFTVLVFTVTLKLALDTHYWTWINHFVIWGSLLFYVIFSL 1058

  Fly  1521 FYNYVIGGPYVG------SLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQK 1579
            .:..:| .|::.      ...|.:.....|:::::.::..:.|.:..|.....:.|:.:::|  :
Zfish  1059 LWGGII-WPFLNYQRMYYVFMQMLSSGPAWLSIILLIIVSLLPDVLKKVLCRALWPTTTERI--Q 1120

  Fly  1580 SLKKIHSRASSDVRRTAS---------SRRGRRS 1604
            :..|::....|:.....|         .|||..|
Zfish  1121 NADKLYKGHLSEFSPLTSLHAPPARKHERRGNES 1154

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	25/52 (48%)
		Cation_ATPase	891..985	CDD:289987	41/108 (38%)
		HAD_like	<1261..1324	CDD:304363	40/63 (63%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	76/260 (29%)
atp11a	XP_005171058.2	P-type_ATPase_APLT_Dnf-like	47..977	CDD:319770	350/1279 (27%)
atp11a	XP_005171058.2	PhoLip_ATPase_C	854..1114	CDD:318452	76/260 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720