DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and Atp8b1

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_001001488.2 Gene:Atp8b1 / 54670 MGIID:1859665 Length:1251 Species:Mus musculus


Alignment Length:1515 Identity:608/1515 - (40%)
Similarity:811/1515 - (53%) Gaps:346/1515 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   151 SDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEF-------NAQF- 207
            |||:...:..|...|.|    |...|:::...::...:..:...:::|||::|       |.:| 
Mouse    25 SDDETEDELEDQGSTVE----PEQNRVNREAEKKRETFRKDCTWQVKANDRKFHEQPHFMNTKFF 85

  Fly   208 -----KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIG 267
                 ||.:|.|||.||:.|||||.||.|||:|.||||||.||:||.||.||:|...||.:||:.
Mouse    86 CIKESKYASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLL 150

  Fly   268 VLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLL 332
            ||.:||:||..||:.||..|.::|||..:.:::|:....||.::||||||||..|.|:.||.|||
Mouse   151 VLGITAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLL 215

  Fly   333 STSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLI 397
            |:||||.||::||||||||||||.|..|..|.:.....|:|..|:|.|.||.|||.|:||.|||.
Mouse   216 SSSEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTGTLF 280

  Fly   398 WRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIV 462
            |:.|.|.||.:||||||||:|||..|:|:|:|||.|||:|:|||||:||.|.:|.|:|:::..|.
Mouse   281 WKNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIF 345

  Fly   463 LFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPI 527
            :.|:.:.|..|||.|.||..:|.:.......|:..|        :..|.|.|:.|.|||||:|||
Mouse   346 IVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATP--------SYRGFLNFWGYIIVLNTMVPI 402

  Fly   528 SLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFN 592
            ||||||||||..||..||||.:|||...:|.||||||||||:||||.|||||||||||||||||.
Mouse   403 SLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFK 467

  Fly   593 KCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVH 657
            ||.|||..|||                                                |:    
Mouse   468 KCCINGTIYGD------------------------------------------------HR---- 480

  Fly   658 AKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLD 722
                                            |||:                             
Mouse   481 --------------------------------DASQ----------------------------- 484

  Fly   723 GSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRL 787
                                                                             
Mouse   485 ----------------------------------------------------------------- 484

  Fly   788 VKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSV 852
                                                     |..||               ::.|
Mouse   485 -----------------------------------------HSHSK---------------IELV 493

  Fly   853 DFSANPHHESDFRWYDRTLLDAVRSDEE-HSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAAL 916
            |||.|...:....:||..|::.::|.:| ....||.||::|||||.:.:||::.|||.||||.||
Mouse   494 DFSWNTFADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLSICHTVMVDRIDGQINYQAASPDEGAL 558

  Fly   917 VSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD-SMVLYCKGADN 980
            |:|||||||.|..||.|:||:..:|....|.:|.|||||:.|||||:|:|..: |:.|||||||.
Mouse   559 VNAARNFGFAFLARTQNTITVSELGSERTYNVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADT 623

  Fly   981 VIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL 1045
            |||:||| .....|..|||.|:.||.|.||||.|..:.:.|:.:.:|.::...|:::..:|::.|
Mouse   624 VIYERLH-RMNPTKQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNNKFMAASVASSNRDEAL 687

  Fly  1046 NAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDE 1110
            :.:|||||.::.|:|.||||||||||||::|:.|..|.||||||||||:|||.|||::|:|||::
Mouse   688 DKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTED 752

  Fly  1111 LADVFIVDGNSV--EEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFM 1173
            ....:..|.||:  ..:|.|..:...|.|    |.|..::||                       
Mouse   753 TTICYGEDINSLLHTRMENQRNRGGVSAK----FAPPVYEPF----------------------- 790

  Fly  1174 QETNLPPTPPPPPAISVVTFRW------DEKNKDNK----GGPDSAECNNLFGDEKGSEDGGTAS 1228
                   .||......::|..|      ::|.|.:|    ..|.:.|...:....:..       
Mouse   791 -------FPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRR------- 841

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVT 1293
              ::|.                ..:.:..|:|:|.:|.|||||||||.|||:||:|:||.|.|:|
Mouse   842 --LEEK----------------KEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAIT 888

  Fly  1294 LAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRY 1358
            ||||||||||:|||.||||||||||||:|||:|||||.||||||:|||||||||||.||||||||
Mouse   889 LAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRY 953

  Fly  1359 FFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRL 1423
            ||||||||||.|.|||.|.|:||||.::..||::||:.|:|||||.:|:.:||||||.||.||.|
Mouse   954 FFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGL 1018

  Fly  1424 YTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVD 1488
            |..|.:..|||.:.|..|:|||..||:|||.||.|.|...|..:|...||:.:....||:.|::.
Mouse  1019 YVVGQRDLLFNYKRFFVSLLHGVLTSMVLFFIPLGAYLQTVGQDGEAPSDYQSFAVTVASALVIT 1083

  Fly  1489 NTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYV---------GSLTQAMKDLTFW 1544
            ...||.|.|||||.||..:|:||:..||.:  .:::...|.:|         |:.:.|::....|
Mouse  1084 VNFQIGLDTSYWTFVNAFSIFGSIALYFGI--MFDFHSAGIHVLFPSAFQFTGTASNALRQPYIW 1146

  Fly  1545 VTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGY 1609
            :|:::||...:.||:|.:|..:.:.||.|||| ||..|::.:..... ||.:..|||..|.||.|
Mouse  1147 LTIILTVAVCLLPVVAIRFLSMTIWPSESDKI-QKHRKRLKAEEQWK-RRQSVFRRGVSSRRSAY 1209

  Fly  1610 AFAHQEGFGRLITSGKIMHK 1629
            ||:||.|:..||:||:.:.|
Mouse  1210 AFSHQRGYADLISSGRSIRK 1229

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 40/77 (52%)
Cation_ATPase 891..985 CDD:289987 56/94 (60%)
HAD_like <1261..1324 CDD:304363 48/62 (77%)
PhoLip_ATPase_C 1324..1571 CDD:292829 126/255 (49%)
Atp8b1NP_001001488.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 8/30 (27%)
PhoLip_ATPase_N 86..142 CDD:292826 34/55 (62%)
ATPase-Plipid 92..1179 CDD:273734 571/1391 (41%)
E1-E2_ATPase 171..>234 CDD:278548 34/62 (55%)
Cation_ATPase 534..628 CDD:289987 56/93 (60%)
HAD_like <875..919 CDD:304363 34/43 (79%)
PhoLip_ATPase_C 919..1173 CDD:292829 126/255 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 273 1.000 Domainoid score I1777
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D39163at33208
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - O PTHR24092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.790

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