Protein Alignment ATP8B and Atp8b2

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001355579.1
• Gene: Atp8b2 / 54667
• MGIID: 1859660
• Length: 1209
• Species: Mus musculus
• Alignment Length: 1454
• Identity: 664/1454 - (45%)
• Similarity: 853/1454 - (58%)
• Gaps: 332/1454 - (22%)

  Fly   190 SENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAIS 254
            :|.|||.||||:|:|.:|:|.:|.||||||::.||||.||.||||.:||.|||.||:|||||.||
Mouse    29 TEEERRARANDREYNEKFQYASNCIKTSKYNIVTFLPVNLFEQFQEVANTYFLFLLILQLIPQIS 93

  Fly   255 SLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRL 319
            ||:..||.:||:.|||:||||||.||..||.||:|||||.|:.|.||.|.:.:|..|.|||:|:|
Mouse    94 SLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRHSQVLINGVLQQEQWMNVCVGDIIKL 158

  Fly   320 DNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICER 384
            :||||||||.||||:|||:|||:|||||||||||:|.:|.:..|.|||| ...|..|:||:|||.
Mouse   159 ENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGD-VSQLARFDGEVICEP 222

  Fly   385 PNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTG 449
            |||.|:||.|||.|:..:|.|.|:.:||||||||||:||:|:|:|||.|||||||||:|:||.|.
Mouse   223 PNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTS 287

  Fly   450 VDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVF 514
            :|||:|.:::.|..|||.:..:.|||.||||..:|..||:||||:..:...:..      |.|.|
Mouse   288 IDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFS------GFLSF 346

  Fly   515 FSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSD 579
            :||.|:|||||||||||||||||...|:.||||::|:.....|.|:||||||||||||::|||||
Mouse   347 WSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSD 411

  Fly   580 KTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAA 644
            ||||||||||.||||||||.|||||.|
Mouse   412 KTGTLTQNIMVFNKCSINGHSYGDVFD-------------------------------------- 438

  Fly   645 PPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRS 709
                :|.||||                  |.:||
Mouse   439 ----VLGHKAE------------------LGERP------------------------------- 450

  Fly   710 QDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTET 774
                                                                             
Mouse   451 ----------------------------------------------------------------- 450

  Fly   775 HNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW 839
                                                    ||
Mouse   451 ----------------------------------------EP----------------------- 452

  Fly   840 SSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV-DGK 903
                        ||||.||..:..|.::|.:||:||:..:.|:|.|||||:||||||:|.. :|:
Mouse   453 ------------VDFSFNPLADKKFLFWDSSLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKNEGE 505

  Fly   904 LEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRG 968
            |.|:||||||.|||:||||||||||:|||.:||:..:|....|:||.||||||:|||||||:|..
Mouse   506 LYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHELGTAITYQLLAILDFNNIRKRMSVIVRNP 570

  Fly   969 DSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032
            :..: |||||||.::.||||...::|.:.|.||||::||:|||||.||.:.|.|:||.:|..|:.
Mouse   571 EGKIRLYCKGADTILLDRLHPPTQELLSSTTDHLNEYAGDGLRTLVLAYKDLDEEYYEEWARRRL 635

  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097
            :|:|:.||||.:|.:||||:||:|.|:|.||||||||.|||::||.|..|.||||||||||||||
Mouse   636 QASLAQDSREDRLASIYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETA 700

  Fly  1098 INIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPL 1162
            :||||||::|||::.:||:|.|::|.||.::||:.::.:             .|..::..|
Mouse   701 VNIGYSCKMLTDDMTEVFVVTGHTVLEVREELRKARKKM-------------VDSSHAVGN---- 748

  Fly  1163 SVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTA 1227
                    .|..:.||                            .|::..::.....|.
Mouse   749 --------GFTYQGNL----------------------------SSSKLTSVLEAVAGE------ 771

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                     :|||:|||||.|.|..::|.:||:.|..|||||||||||||||.||||:|:.|.||
Mouse   772 ---------YALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAV 827

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |||||||||||||||.||||||||||||:||||:||||.:||::|:|||||||||||.||||||.
Mouse   828 TLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLC 892

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            ||||||||||:.|.|:..|||||||||:|..||::||:.||||||||:|||:|||.::.|:|:|:
Mouse   893 YFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPK 957

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIV 1487
            ||.||..:.|||.|||...:..|.:||:::|.|||||:.:....:|..::|:.:....|||.|::
Mouse   958 LYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVI 1022

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVL----------DYFYNYVIGGPYVGSLTQAMKDLT 1542
            ..:.||.|.|.|||.:||..|||||..||.:          |.|.|..   .:||:....:...|
Mouse  1023 VVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQF---RFVGNAQNTLAQPT 1084

  Fly  1543 FWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSL----KKIHSRASSDVRRTASSRRGRR 1603
            .|:|:.:|....:.||:|::|..|.:.|.|||.:|...|    :|...|....|.||.|.
Mouse  1085 VWLTIALTTAVCIMPVVAFRFLRLSLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSR----- 1144

  Fly  1604 SVRSGYAFAHQEGFGRLITSGKIM 1627
              ||||||:||||||.||.|||.|
Mouse  1145 --RSGYAFSHQEGFGELIMSGKNM 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	244/390 (63%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	308/572 (54%)
Atp8b2	NP_001355579.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	12..36		4/6 (67%)
		P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	581/1246 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1179..1209