DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp8b2

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_001355579.1	Gene:	Atp8b2 / 54667	MGIID:	1859660	Length:	1209	Species:	Mus musculus

Alignment Length:	1454	Identity:	664/1454 - (45%)
Similarity:	853/1454 - (58%)	Gaps:	332/1454 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 SENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAIS 254
            :|.|||.||||:|:|.:|:|.:|.||||||::.||||.||.||||.:||.|||.||:|||||.||
Mouse    29 TEEERRARANDREYNEKFQYASNCIKTSKYNIVTFLPVNLFEQFQEVANTYFLFLLILQLIPQIS 93

  Fly   255 SLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRL 319
            ||:..||.:||:.|||:||||||.||..||.||:|||||.|:.|.||.|.:.:|..|.|||:|:|
Mouse    94 SLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRHSQVLINGVLQQEQWMNVCVGDIIKL 158

  Fly   320 DNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICER 384
            :||||||||.||||:|||:|||:|||||||||||:|.:|.:..|.|||| ...|..|:||:|||.
Mouse   159 ENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGD-VSQLARFDGEVICEP 222

  Fly   385 PNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTG 449
            |||.|:||.|||.|:..:|.|.|:.:||||||||||:||:|:|:|||.|||||||||:|:||.|.
Mouse   223 PNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTS 287

  Fly   450 VDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVF 514
            :|||:|.:::.|..|||.:..:.|||.||||..:|..||:||||:..:...:..      |.|.|
Mouse   288 IDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWDEAVDSAFFS------GFLSF 346

  Fly   515 FSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSD 579
            :||.|:|||||||||||||||||...|:.||||::|:.....|.|:||||||||||||::|||||
Mouse   347 WSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSD 411

  Fly   580 KTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAA 644
            ||||||||||.||||||||.|||||.|
Mouse   412 KTGTLTQNIMVFNKCSINGHSYGDVFD-------------------------------------- 438

  Fly   645 PPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRS 709
                :|.||||                  |.:||
Mouse   439 ----VLGHKAE------------------LGERP------------------------------- 450

  Fly   710 QDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTET 774

Mouse   451 ----------------------------------------------------------------- 450

  Fly   775 HNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNW 839
                                                    ||
Mouse   451 ----------------------------------------EP----------------------- 452

  Fly   840 SSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV-DGK 903
                        ||||.||..:..|.::|.:||:||:..:.|:|.|||||:||||||:|.. :|:
Mouse   453 ------------VDFSFNPLADKKFLFWDSSLLEAVKMGDPHTHEFFRLLSLCHTVMSEEKNEGE 505

  Fly   904 LEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRG 968
            |.|:||||||.|||:||||||||||:|||.:||:..:|....|:||.||||||:|||||||:|..
Mouse   506 LYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHELGTAITYQLLAILDFNNIRKRMSVIVRNP 570

  Fly   969 DSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032
            :..: |||||||.::.||||...::|.:.|.||||::||:|||||.||.:.|.|:||.:|..|:.
Mouse   571 EGKIRLYCKGADTILLDRLHPPTQELLSSTTDHLNEYAGDGLRTLVLAYKDLDEEYYEEWARRRL 635

  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097
            :|:|:.||||.:|.:||||:||:|.|:|.||||||||.|||::||.|..|.||||||||||||||
Mouse   636 QASLAQDSREDRLASIYEEVESDMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETA 700

  Fly  1098 INIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPL 1162
            :||||||::|||::.:||:|.|::|.||.::||:.::.:             .|..::..|
Mouse   701 VNIGYSCKMLTDDMTEVFVVTGHTVLEVREELRKARKKM-------------VDSSHAVGN---- 748

  Fly  1163 SVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTA 1227
                    .|..:.||                            .|::..::.....|.
Mouse   749 --------GFTYQGNL----------------------------SSSKLTSVLEAVAGE------ 771

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                     :|||:|||||.|.|..::|.:||:.|..|||||||||||||||.||||:|:.|.||
Mouse   772 ---------YALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAV 827

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |||||||||||||||.||||||||||||:||||:||||.:||::|:|||||||||||.||||||.
Mouse   828 TLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLC 892

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            ||||||||||:.|.|:..|||||||||:|..||::||:.||||||||:|||:|||.::.|:|:|:
Mouse   893 YFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPK 957

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIV 1487
            ||.||..:.|||.|||...:..|.:||:::|.|||||:.:....:|..::|:.:....|||.|::
Mouse   958 LYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATSLVI 1022

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVL----------DYFYNYVIGGPYVGSLTQAMKDLT 1542
            ..:.||.|.|.|||.:||..|||||..||.:          |.|.|..   .:||:....:...|
Mouse  1023 VVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQF---RFVGNAQNTLAQPT 1084

  Fly  1543 FWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSL----KKIHSRASSDVRRTASSRRGRR 1603
            .|:|:.:|....:.||:|::|..|.:.|.|||.:|...|    :|...|....|.||.|.
Mouse  1085 VWLTIALTTAVCIMPVVAFRFLRLSLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSR----- 1144

  Fly  1604 SVRSGYAFAHQEGFGRLITSGKIM 1627
              ||||||:||||||.||.|||.|
Mouse  1145 --RSGYAFSHQEGFGELIMSGKNM 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	42/64 (66%)
		Cation_ATPase	891..985	CDD:289987	59/95 (62%)
		HAD_like	<1261..1324	CDD:304363	52/62 (84%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	124/256 (48%)
Atp8b2	NP_001355579.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..36		4/6 (67%)
		P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	581/1246 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	478	1.000	Domainoid score	I420
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23226
Inparanoid	1	1.050	1303	1.000	Inparanoid score	I157
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980