Protein Alignment ATP8B and ATP8B1

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001361314.1
• Gene: ATP8B1 / 5205
• HGNCID: 3706
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1514
• Identity: 609/1514 - (40%)
• Similarity: 811/1514 - (53%)
• Gaps: 344/1514 - (22%)

  Fly   151 SDDQELYKQRDPSVTSESKSV-PSLRRLSQIRRRRSSYYFSENERRIRANDKEF-------NAQF 207
            |||     :.:..:..:..:| |...|:::........:..|...:::|||:::       |.:|
Human    25 SDD-----ETEDELDDQGSAVEPEQNRVNREAEENREPFRKECTWQVKANDRKYHEQPHFMNTKF 84

  Fly   208 ------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLI 266
                  ||.||.|||.||:.|||:|.||.|||:|.||.|||.||:||.:|.||:|...||.:||:
Human    85 LCIKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLL 149

  Fly   267 GVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLL 331
            .||.:||:||..||:.||..|.::|||..:.:::|:...|||.|:||||||||..|.||.||.||
Human   150 VVLGVTAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKVAKWKEIQVGDVIRLKKNDFVPADILL 214

  Fly   332 LSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL 396
            ||:||||.||::||||||||||||.|..|..|.:...|.|:|..|:|.|.||.|||.|:||.|||
Human   215 LSSSEPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFTGTL 279

  Fly   397 IWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGI 461
            .||...|.||.:||||||||:|||.:|:|:|:|||.|||:|:|||||:||.|.:|.|:|:::..|
Human   280 FWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTI 344

  Fly   462 VLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVP 526
            .:.|:.:.|..|||.|.||..:|..     .|.....:|..|   :..|.|:|:.|.|||||:||
Human   345 FVVLILLSAGLAIGHAYWEAQVGNS-----SWYLYDGEDDTP---SYRGFLIFWGYIIVLNTMVP 401

  Fly   527 ISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTF 591
            |||||||||||..||..||||.:|||...:|.||||||||||:||||.|||||||||||||||||
Human   402 ISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTF 466

  Fly   592 NKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEV 656
            .||.|||:.|||                                                |:
Human   467 KKCCINGQIYGD------------------------------------------------HR--- 480

  Fly   657 HAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRL 721
                                             |||:
Human   481 ---------------------------------DASQ---------------------------- 484

  Fly   722 DGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKR 786
                                                                 ||     ||:
Human   485 -----------------------------------------------------HN-----HNK-- 489

  Fly   787 LVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQS 851
                                                                          ::.
Human   490 --------------------------------------------------------------IEQ 492

  Fly   852 VDFSANPHHESDFRWYDRTLLDAVRSDEE-HSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAA 915
            ||||.|.:.:....:||..|::.::|.:| ....||.|||:|||||.:..||:|.|||.||||.|
Human   493 VDFSWNTYADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLAVCHTVMVDRTDGQLNYQAASPDEGA 557

  Fly   916 LVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGAD 979
            ||:|||||||.|..||.|:|||..:|....|.:|.|||||:.|||||:|:|..:..: |||||||
Human   558 LVNAARNFGFAFLARTQNTITISELGTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGAD 622

  Fly   980 NVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQK 1044
            .|||:||| .....|..|||.|:.||.|.||||.|..:.:.|:.:.:|..:...|:::..:|::.
Human   623 TVIYERLH-RMNPTKQETQDALDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTNRDEA 686

  Fly  1045 LNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTD 1109
            |:.:|||||.::.|:|.||||||||||||::|:.|..|.||||||||||:|||.|||::|:|||:
Human   687 LDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTE 751

  Fly  1110 ELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQ 1174
            :....:..|.||:  :..::...:....:|.:|.|                |:     |.|.|
Human   752 DTTICYGEDINSL--LHARMENQRNRGGVYAKFAP----------------PV-----QESFF-- 791

  Fly  1175 ETNLPPTPPPPPAISVVTFRW------DEKNKDNK----GGPDSAECNNLFGDEKGSEDGGTASI 1229
                   ||......::|..|      ::|.|.||    ..|.:.|...:....|
Human   792 -------PPGGNRALIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSK---------- 839

  Fly  1230 VVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTL 1294
                           ..:.....:.:..|:|:|.:|.|||||||||.|||:||:|:||.|.|:||
Human   840 ---------------RRLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITL 889

  Fly  1295 AIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYF 1359
            |||||||||:|||.||||||||||||:|||:|||||.||||||:|||||||||||.|||||||||
Human   890 AIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYF 954

  Fly  1360 FYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLY 1424
            |||||||||.|.|||.|.|:||||.::..||::||:.|||||||.:|:.:||||||.||.||.||
Human   955 FYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLY 1019

  Fly  1425 TPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDN 1489
            ..|.:..|||.:.|..|:|||..||::||.||.|.|...|..:|...||:.:....:|:.|::..
Human  1020 IVGQRDLLFNYKRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIASALVITV 1084

  Fly  1490 TAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYV---------GSLTQAMKDLTFWV 1545
            ..||.|.|||||.||..:|:||:..||.:  .:::...|.:|         |:.:.|::....|:
Human  1085 NFQIGLDTSYWTFVNAFSIFGSIALYFGI--MFDFHSAGIHVLFPSAFQFTGTASNALRQPYIWL 1147

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYA 1610
            |:::.|...:.||:|.:|..:.:.||.|||| ||..|::.:..... ||....|||..:.||.||
Human  1148 TIILAVAVCLLPVVAIRFLSMTIWPSESDKI-QKHRKRLKAEEQWQ-RRQQVFRRGVSTRRSAYA 1210

  Fly  1611 FAHQEGFGRLITSGKIMHK 1629
            |:||.|:..||:||:.:.|
Human  1211 FSHQRGYADLISSGRSIRK 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	37/77 (48%)
		Cation_ATPase	891..985	CDD:289987	57/94 (61%)
		HAD_like	<1261..1324	CDD:304363	48/62 (77%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	124/255 (49%)
ATP8B1	NP_001361314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54		6/33 (18%)
		P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	532/1256 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	284	1.000	Domainoid score	I1635
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.930