Protein Alignment ATP8B and ATP8A2

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_057613.4
• Gene: ATP8A2 / 51761
• HGNCID: 13533
• Length: 1188
• Species: Homo sapiens
• Alignment Length: 1507
• Identity: 493/1507 - (32%)
• Similarity: 692/1507 - (45%)
• Gaps: 419/1507 - (27%)

  Fly   173 SLRRLSQIRRR----RSS--YYFSENE---------------RRIRANDKEFNAQFKYHNNYIKT 216
            ||.|.|:||..    |||  |..:|:|               |.|..|....|   |:.:|.|.|
Human    14 SLPRRSRIRSSVGPVRSSLGYKKAEDEMSRATSVGDQLEAPARTIYLNQPHLN---KFRDNQIST 75

  Fly   217 SKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI 281
            :|||:.||||..|.||.:|.||.:||.:.:||.||.:|.....||.:|||.:||:..:|:..:|.
Human    76 AKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDF 140

  Fly   282 QRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETA 346
            :||.:|:.||.:|:..||||......|.||.|||::::.|.|::.||.:|||:|||..:|::|||
Human   141 KRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETA 205

  Fly   347 ELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRF-ALDNEKI 410
            .||||||||.:|.|:.|.::..| :.|...:|.|.||.||..|..|.|.|...|:.. ||..::|
Human   206 NLDGETNLKIRQGLSHTADMQTR-EVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQI 269

  Fly   411 LLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGIVLFLVSICALF 472
            ||||..||||||.:|:||:.|.||||||||.|...|.:.|:::.|   .::.||:|.:..:.
Human   270 LLRGTQLRNTQWVFGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVS--- 331

  Fly   473 AIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATV-----IGLLVFFSYAIVLNTVVPISLYVS 532
            :.|...|....|:.     .|       ||....|.     ..||.|.   |:.|.::||||.|:
Human   332 SAGALYWNRSHGEK-----NW-------YIKKMDTTSDNFGYNLLTFI---ILYNNLIPISLLVT 381

  Fly   533 VEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSIN 597
            :||:::.|:..||||.:|||...:|.|.|||:.|||||||::|:|||||||||.|||.|.||||.
Human   382 LEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIA 446

  Fly   598 GRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTS 662
            |.:||                                                 |..|:..:.:|
Human   447 GVTYG-------------------------------------------------HFPELAREPSS 462

  Fly   663 MVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGL 727
                             .|..|..||.                 |.|.|.|..||...::.....
Human   463 -----------------DDFCRMPPPC-----------------SDSCDFDDPRLLKNIEDRHPT 493

  Fly   728 SPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRF 792
            :|                   |:|.
Human   494 AP-------------------CIQE---------------------------------------- 499

  Fly   793 KKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSAN 857
                                                                             
Human   500 ----------------------------------------------------------------- 499

  Fly   858 PHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARN 922
                                       |..|||:||||:.|.....:.|||.||||||||..|:.
Human   500 ---------------------------FLTLLAVCHTVVPEKDGDNIIYQASSPDEAALVKGAKK 537

  Fly   923 FGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRL 986
            .||||..|||.|:.||.|||.:.:.:||:|:|::.|||||||:|.....: ||||||||||::||
Human   538 LGFVFTARTPFSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERL 602

  Fly   987 HGGQEDLK--ARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIY 1049
               .:|.|  ..|..||..||.||||||.:|...|:|..|.:|....|||:..:..|.|:|...|
Human   603 ---SKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECY 664

  Fly  1050 EEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADV 1114
            |.||..:.|:|.|||||:||.|||::||.|..|.|||||||||||||||||||||:|::..:|.:
Human   665 EIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALI 729

  Fly  1115 FIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLP 1179
            .:                                      .:.::|.....:||
Human   730 LL--------------------------------------KEDSLDATRAAITQ----------- 745

  Fly  1180 PTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGH 1244
                                       ...:..||.|.|                ...||:::||
Human   746 ---------------------------HCTDLGNLLGKE----------------NDVALIIDGH 767

  Fly  1245 SLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAA 1309
            :|.:.||.|:...|||:|..|||||||||:||||:.:|:::|:...|:|||||||||||.||:.|
Human   768 TLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTA 832

  Fly  1310 HIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYS 1374
            |:||||||.||:||..:|||:||||.|||:||||||.|||.|:.|.:.|.||||....:...|::
Human   833 HVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFA 897

  Fly  1375 LFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFI 1439
            ...|||.|.:|:...|.:||:.:|:||...||:||:..:.::.|.||:||......|.||.:.|.
Human   898 FVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFW 962

  Fly  1440 YSVLHGAFTSLVLFLIPY-GVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVV 1503
            ...::....||:||..|. .:..|.|..:|. .:|::.:|.:|.|.::|....:..|.|:.||..
Human   963 GHCINALVHSLILFWFPMKALEHDTVLTSGH-ATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKF 1026

  Fly  1504 NHVTIWGSLVWYFVLDYFYNYV-----IGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAY-- 1561
            :|:.:|||::.:.|....|:.:     |.....|..|..:....||:.:.:...|.:...:|:
Human  1027 SHLAVWGSMLTWLVFFGIYSTIWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRA 1091

  Fly  1562 -----KFYLLDVHPSLSDKI------------------RQKSLKKIHSRASSDVRRTASSRRGRR 1603
                 |..||:....|..|.                  |.:.:|::..:....:.|.:|.::|
Human  1092 AKHTCKKTLLEEVQELETKSRVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQG-- 1154

  Fly  1604 SVRSGYAFAHQE 1615
             |..||||:.:|
Human  1155 -VPHGYAFSQEE 1165

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	27/64 (42%)
		Cation_ATPase	891..985	CDD:289987	52/94 (55%)
		HAD_like	<1261..1324	CDD:304363	41/62 (66%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	84/259 (32%)
ATP8A2	NP_057613.4	ATPase-Plipid	68..1106	CDD:273734	463/1386 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1162..1188		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.730