DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp9b

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_006526569.1	Gene:	Atp9b / 50771	MGIID:	1354757	Length:	1167	Species:	Mus musculus

Alignment Length:	1549	Identity:	385/1549 - (24%)
Similarity:	596/1549 - (38%)	Gaps:	501/1549 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SFYSLA---PGGGNPPPNKSDDQELYKQRDPSVTSE------SKSVPSLRRLSQIRRRRSSYYF- 189
            ::||.|   ||.......:.:|:..:....|.:.||      .....:|.|....||:|...:|
Mouse    23 AYYSSAGPGPGADRRGRYQLEDESAHLDEMPLMMSEEGFENDESDYHTLPRARITRRKRGLEWFV 87

  Fly   190 ------------------SENERRIRAN-------DKEFNAQFKYHNNYIKTSKYSLFTFLPFNL 229
                              .:.::.::|.       :|   .:.|:..|.||..||::|||:|..|
Mouse    88 CGGWKFLCTSCCDWLINVCQRKKELKARTVWLGCPEK---CEEKHPRNSIKNQKYNVFTFIPGVL 149

  Fly   230 LEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNR- 293
            .|||:...|.|||.:...|.:||:......|...||..||.:|..::|.|:.:|...|.::|::
Mouse   150 YEQFKFFLNLYFLVVSCSQFVPALKIGYLYTYWAPLGFVLAVTIAREAIDEFRRFQRDKEMNSQL 214

  Fly   294 KSKTLRNGKLVEAKWSEVQVGDVIRLD---------------------NNQFVAADTLLLSTSEP 337
            .||....|| |:.|.|::||||:|.::                     .||.:.:|.:.|.|||.
Mouse   215 YSKLTVRGK-VQVKSSDIQVGDLIIVEKAFLSCGQHPLMYMLQASASFQNQRIPSDMVFLRTSEK 278

  Fly   338 NGLCFIETAELDGETNLKAK---QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWR 399
            .|.|||.|.:|||||:.|.|   .|......|||    |::.:..:..::|...::.|:||....
Mouse   279 AGSCFIRTDQLDGETDWKLKVAVSCTQRLPALGD----LFSISAYVYAQKPQLDIHSFEGTFTRE 339

  Fly   400 GQRFALDNEKILLRGCVLRNTQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN 455
                  |::..:.....:.||.|.         .|||::.|.:|:.:.|:...:.|...:|..||
Mouse   340 ------DSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELN 398

  Fly   456 FIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIV 520
            .:...:.|.||    :.::.....:|..|       ||..           .:...|:.|||
Mouse   399 QLTKALFLALV----VLSVVMVTLQGFAG-------PWYR-----------NLFRFLLLFSY--- 438

  Fly   521 LNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLT 585
               ::||||.|::::.:....::|..||.:  |.|    ..||:|:.||||::.|:.:|||||||
Mouse   439 ---IIPISLRVNLDMGKAAYGWMIMKDENI--PGT----VVRTSTIPEELGRLVYLLTDKTGTLT 494

  Fly   586 QNIMTFNKCSINGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPII 649
            ||.|.|.:..:...||| |.:|          |.|:...||
Mouse   495 QNEMVFKRLHLGTVSYGTDTMD----------EIQSHVLNS------------------------ 525

  Fly   650 LVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAP-SRSQDAD 713
               ..:||::.:.                                     |...||| .|||
Mouse   526 ---YLQVHSQPSG-------------------------------------HNPSSAPLRRSQ--- 547

  Fly   714 AGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMH 778
                                                        ||..|||
Mouse   548 --------------------------------------------SSTPKVK-------------- 554

  Fly   779 HSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSP 843
                                                       .|.:...|...||.|...:.:|
Mouse   555 -------------------------------------------KSVSSRIHEAVKAIALCHNVTP 576

  Fly   844 HRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQA 908
                   ..:..|....|::|...|:..     |||..:                       |||
Mouse   577 -------VYEARAGITGETEFAEADQDF-----SDENRT-----------------------YQA 606

  Fly   909 QSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYELLNILDFNNVRKRMSVILRRGDS-- 970
            .||||.|||....:.|....:|...|:.::. .||...|.:|.:..|.:..|||.:|:|...:
Mouse   607 SSPDEVALVRWTESVGLTLISRDLASMQLKTPSGQVLTYCILQMFPFTSESKRMGIIVRDESTAE 671

  Fly   971 MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAA 1035
            :..|.|||| |....:....:.|    ::.....|.||||||.:|:|.|||:.|.|:.||..:|.
Mouse   672 ITFYMKGAD-VAMSTIVQYNDWL----EEECGNMAREGLRTLVVAKRTLTEEQYQDFESRYSQAK 731

  Fly  1036 LSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINI 1100
            ||:..|..|:.|:.|.:|.||:|:.:|.:||:||..|..::..|:|||||||:|||||.|||..|
Mouse   732 LSIHDRALKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGDKLETATCI 796

  Fly  1101 GYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVT 1165
            ..|..|:: ...|:.:                         |||
Mouse   797 AKSSHLVS-RTQDIHV-------------------------FRP--------------------- 814

  Fly  1166 MTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIV 1230
            :|.......|.|              .||  .|:          :|
Mouse   815 VTSRGEAHLELN--------------AFR--RKH----------DC------------------- 834

  Fly  1231 VDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLA 1295
                   |||::|.||..||. ..|::.:::|.||.||:|||.:|.|||.:|.|:::.....|.|
Mouse   835 -------ALVISGDSLEVCLR-YYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQHTRKRTCA 891

  Fly  1296 IGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFF 1360
            ||||.||||||:||..|:||.|:||.||.|::|:||.|||::.|||:||||.||.|.....::..
Mouse   892 IGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVM 956

  Fly  1361 YKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYT 1425
            ::....:.....:|....|::..::....:..|...||..||.:| |.:|||..:.::.:|.||.
Mouse   957 HRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMAILYPELYK 1020

  Fly  1426 PGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVV---SDHMTLGAVVATILIV 1487
            ...|....:.:.|:..||             ..:|:.|:...|.::   .:.:.:.|:..|.||:
Mouse  1021 DLTKGRSLSFKTFLIWVL-------------ISIYQGGILMYGALLLFEDEFVHVVAISFTALIL 1072

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLT-------------QAMK 1539
            .....::|....|    |        |..|:..|.:.   |.||.||.             .|..
Mouse  1073 TELLMVALTIRTW----H--------WLMVVAEFLSL---GCYVASLAFLNEYFGIGRVSFGAFL 1122

  Fly  1540 DLTF-------WVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHS 1586
            |:.|       |....|||::.: |:...|:        |..|:...|..|:.|
Mouse  1123 DVAFITTVTFLWKVSAITVVSCL-PLYVLKY--------LKRKLSPPSYSKLSS 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/71 (32%)
		Cation_ATPase	891..985	CDD:289987	29/96 (30%)
		HAD_like	<1261..1324	CDD:304363	35/62 (56%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	63/269 (23%)
Atp9b	XP_006526569.1	P-type_ATPase_APLT_Neo1-like	131..1076	CDD:319841	342/1321 (26%)
Atp9b	XP_006526569.1	Cation_ATPase	596..680	CDD:372530	29/111 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.020