Protein Alignment ATP8B and Atp8a2

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_056618.1
• Gene: Atp8a2 / 50769
• MGIID: 1354710
• Length: 1148
• Species: Mus musculus
• Alignment Length: 1461
• Identity: 482/1461 - (32%)
• Similarity: 686/1461 - (46%)
• Gaps: 390/1461 - (26%)

  Fly   194 RRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTP 258
            |.|..|....|   |:.:|.|.|:|||:.||||..|.||.:|.||.:||.:.:||.||.:|....
Mouse    16 RIIYLNQSHLN---KFCDNRISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGR 77

  Fly   259 VTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQ 323
            .||.:||:.:||:..:|:..:|.:||.:|:.||.:|:..||||......|.||.|||::::.|.|
Mouse    78 YTTLVPLVIILTIAGIKEIIEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVLNGQ 142

  Fly   324 FVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNL 388
            ::.||.:|.|:|||.|:|::|||.||||||||.:|.|:.|.::..| |.|...:|.|.||.||..
Mouse   143 YLPADMVLFSSSEPQGMCYVETANLDGETNLKIRQGLSHTTDMQTR-DVLMKLSGRIECEGPNRH 206

  Fly   389 LNKFDGTLIWRGQ-RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDR 452
            |..|.|.|...|: ..||..::|||||..||||||.:||||:.|.|:||||||.|...|.:.|::
Mouse   207 LYDFTGNLHLDGKSSVALGPDQILLRGTQLRNTQWVFGVVVYTGHDSKLMQNSTKAPLKRSNVEK 271

  Fly   453 LLN---FIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIG--LL 512
            :.|   .::.||:|.:..:.   ::|...|.|..|..     .|  .|.|  :.|.:...|  ||
Mouse   272 VTNVQILVLFGILLVMALVS---SVGALFWNGSHGGK-----SW--YIKK--MDTNSDNFGYNLL 324

  Fly   513 VFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIF 577
            .|.   |:.|.::||||.|::||:::.|:..||||.:|||...:|.|.|||:.|||||||::|:|
Mouse   325 TFI---ILYNNLIPISLLVTLEVVKYTQALFINWDMDMYYIENDTPAMARTSNLNEELGQVKYLF 386

  Fly   578 SDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPP 642
            ||||||||.|||.|.||||.|.:||...:|
Mouse   387 SDKTGTLTCNIMNFKKCSIAGVTYGHFPEL----------------------------------- 416

  Fly   643 AAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPS 707
                                                                            :
Mouse   417 ----------------------------------------------------------------A 417

  Fly   708 RSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQT 772
            |.|.:|                                       ...|.:||     .:||
Mouse   418 REQSSD---------------------------------------DFCRMTSC-----TNDS--- 435

  Fly   773 ETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFAT 837
                   ...|..||:|                 .:|   |:.|
Mouse   436 -------CDFNDPRLLK-----------------NIE---DQHP--------------------- 452

  Fly   838 NWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDG 902
               ::|    .:|.                                 |..|||:||||:.|....
Mouse   453 ---TAP----CIQE---------------------------------FLTLLAVCHTVVPEKDGD 477

  Fly   903 KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRR 967
            ::.|||.||||||||..|:..||||..|||.|:.||.|||.:.:.:||:|:|::.|||||||:|.
Mouse   478 EIIYQASSPDEAALVKGAKKLGFVFTGRTPYSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRL 542

  Fly   968 GDSMV-LYCKGADNVIYDRLHGGQEDLK--ARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRS 1029
            ....: ||||||||||::||   .:|.|  ..|..||..||.||||||.:|...|:|..|.:|..
Mouse   543 PSGQLRLYCKGADNVIFERL---SKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLK 604

  Fly  1030 RQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQ 1094
            ..|||::.:..|.|:|...||.||..:.|:|.|||||:||.|||::||.|..|.|||||||||||
Mouse   605 VYQEASIILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQ 669

  Fly  1095 ETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNM 1159
            ||||||||||:|::..:|.:.:                                      .:.::
Mouse   670 ETAINIGYSCRLVSQNMALILL--------------------------------------KEDSL 696

  Fly  1160 DPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDG 1224
            |.....:||                                      ...:..||.|.|
Mouse   697 DATRAAITQ--------------------------------------HCTDLGNLLGKE------ 717

  Fly  1225 GTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAK 1289
                      ...||:::||:|.:.||.|:...|||:|..|||||||||:||||:.:|:::|:..
Mouse   718 ----------NDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRV 772

  Fly  1290 NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCK 1354
            .|:|||||||||||.||:.||:||||||.||:||..:|||:||||.|||:||||||.|||.|:.|
Mouse   773 KAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTK 837

  Fly  1355 FLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLE 1419
            .:.|.||||....:...|::...|||.|.:|:...|.:||:.:|:||...||:||:..:.::.|.
Mouse   838 CILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLR 902

  Fly  1420 FPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATI 1484
            ||:||.....:|.||.:.|....::....||:||.:|....:..........:|::.:|.:|.|.
Mouse   903 FPQLYRITQNAEGFNTKVFWGHCINALVHSLILFWVPMKALEHDTPVTSGHATDYLFVGNIVYTY 967

  Fly  1485 LIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYV-----IGGPYVGSLTQAMKDLTFW 1544
            ::|....:..|.|:.||..:|:.:|||::.:.|....|:.:     |.....|..|..:....||
Mouse   968 VVVTVCLKAGLETTAWTKFSHLAVWGSMLIWLVFFGVYSTIWPTIPIAPDMKGQATMVLSSAYFW 1032

  Fly  1545 VTMLITVMALVAPVLAY-------KFYLLDVHPSLSDKI------------------RQKSLKKI 1584
            :.:.:...|.:...:|:       |..||:....|..|.                  |.:.:|::
Mouse  1033 LGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVMGKAMLRDSNGKRMNERDRLIKRL 1097

  Fly  1585 HSRASSDVRRTASSRRGRRSVRSGYAFAHQE 1615
            ..:....:.||.|.   ::.|..||||:.:|
Mouse  1098 SRKTPPTLFRTGSI---QQCVSHGYAFSQEE 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	178/396 (45%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	240/573 (42%)
Atp8a2	NP_056618.1	ATPase-Plipid	28..1066	CDD:273734	464/1382 (34%)