Protein Alignment ATP8B and ATP9B

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_011524265.1
• Gene: ATP9B / 374868
• HGNCID: 13541
• Length: 1174
• Species: Homo sapiens
• Alignment Length: 1436
• Identity: 360/1436 - (25%)
• Similarity: 562/1436 - (39%)
• Gaps: 472/1436 - (32%)

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            |:..|.||..||::|||:|..|.|||:...|.|||.:...|.:||:......|...||..||.:|
Human   130 KHPRNSIKNQKYNVFTFIPGVLYEQFKFFLNLYFLVISCSQFVPALKIGYLYTYWAPLGFVLAVT 194

  Fly   273 AVKDAYDDIQRHISDSQVNNR-KSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            ..::|.|:.:|...|.:||:: .||....|| |:.|.|::||||:|.::.||.:.:|.:.|.|||
Human   195 MTREAIDEFRRFQRDKEVNSQLYSKLTVRGK-VQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSE 258

  Fly   337 PNGLCFIETAELDGETNLKAK---QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIW 398
            ..|.|||.|.:|||||:.|.|   .|..:...|||    |::.:..:..::|...::.|:||...
Human   259 KAGSCFIRTDQLDGETDWKLKVAVSCTQQLPALGD----LFSISAYVYAQKPQMDIHSFEGTFTR 319

  Fly   399 RGQRFALDNEKILLRGCVLRNTQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVDRLL 454
            .      |::..:.....:.||.|.         .|||::.|.:|:.:.|:...:.|...:|..|
Human   320 E------DSDPPIHESLSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLEL 378

  Fly   455 NFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAI 519
            |.:...:.|.||::    :|.....:|.:|       ||..           .:...|:.|||
Human   379 NRLTKALFLALVAL----SIVMVTLQGFVG-------PWYR-----------NLFRFLLLFSY-- 419

  Fly   520 VLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTL 584
                ::||||.|::::.:.|..:::..||.:  |.|    ..||:|:.||||::.|:.:||||||
Human   420 ----IIPISLRVNLDMGKAVYGWMMMKDENI--PGT----VVRTSTIPEELGRLVYLLTDKTGTL 474

  Fly   585 TQNIMTFNKCSINGRSYG-DVID-LRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPP 647
            |||.|.|.:..:...||| |.:| :::......::.|:....:||.:.|
Human   475 TQNEMIFKRLHLGTVSYGADTMDEIQSHVRDSYSQMQSQAGGNNTGSTP---------------- 523

  Fly   648 IILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDA 712
               :.||:..|.|                                        ||.|..||..:|
Human   524 ---LRKAQSSAPK----------------------------------------VRKSVSSRIHEA 545

  Fly   713 DAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNM 777
                                                     :.....|..|..:::|
Human   546 -----------------------------------------VKAIVLCHNVTPVYES-------- 561

  Fly   778 HHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSS 842
                                                                             
Human   562 ----------------------------------------------------------------- 561

  Fly   843 PHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQ 907
              |....:..:|:   ..:.||            |||..:                       ||
Human   562 --RAGVTEETEFA---EADQDF------------SDENRT-----------------------YQ 586

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYELLNILDFNNVRKRMSVILRRGDS- 970
            |.||||.|||....:.|....:|...|:.::. .||...:.:|.:..|.:..|||.||:|...:
Human   587 ASSPDEVALVQWTESVGLTLVSRDLTSMQLKTPSGQVLSFCILQLFPFTSESKRMGVIVRDESTA 651

  Fly   971 -MVLYCKGADNVI------YDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDW- 1027
             :..|.||||..:      .|.|           ::.....|.||||||.:|::.|||:.|.|:
Human   652 EITFYMKGADVAMSPIVQYNDWL-----------EEECGNMAREGLRTLVVAKKALTEEQYQDFE 705

  Fly  1028 -------------------------RSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDK 1067
                                     :||..:|.|||..|..|:.|:.|.:|.||:|:.:|.:||:
Human   706 PMQSSSVESTHSTYTCAHRRLPLCPQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVEDQ 770

  Fly  1068 LQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQF 1132
            ||..|..::..|:|||||||:|||||.|||..|..|..|:: ...|:.|.         :|:...
Human   771 LQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVS-RTQDIHIF---------RQVTSR 825

  Fly  1133 KESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDE 1197
            .|:....|.||                                                     .
Human   826 GEAHLELNAFR-----------------------------------------------------R 837

  Fly  1198 KNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIA 1262
            |:          :|                          |||::|.||..||. ..|::|:::|
Human   838 KH----------DC--------------------------ALVISGDSLEVCLK-YYEHEFVELA 865

  Fly  1263 SQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSS 1327
            .||.||:|||.:|.|||.:|.|:::.....|.|||||.||||||:||..|:||.|:||.||.|::
Human   866 CQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAA 930

  Fly  1328 DYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISV 1392
            |:||.|||::.|||:||||.||.|.....::..::....:.....:|....|::..::....:..
Human   931 DFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVG 995

  Fly  1393 YNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPY 1457
            |...||..||.:| |.:|||..:.::.:|.||....|....:.:.|:..||             .
Human   996 YATIYTMFPVFSL-VLDQDVKPEMAMLYPELYKDLTKGRSLSFKTFLIWVL-------------I 1046

  Fly  1458 GVYKDGVSANGFVV---SDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLD 1519
            .:|:.|:...|.:|   |:.:.:.|:..|.||:.....::|....|    |        |..|:.
Human  1047 SIYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTW----H--------WLMVVA 1099

  Fly  1520 YFYNYVIGGPYVGSLT-------------QAMKDLTF-------WVTMLITVMALVAPVLAYKFY 1564
            .|.:.   |.||.||.             .|..|:.|       |....|||::.: |:...|:.
Human  1100 EFLSL---GCYVSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCL-PLYVLKYL 1160

  Fly  1565 LLDVHP 1570
            ...:.|
Human  1161 RRKLSP 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	21/51 (41%)
		Cation_ATPase	891..985	CDD:289987	28/102 (27%)
		HAD_like	<1261..1324	CDD:304363	35/62 (56%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	66/270 (24%)
ATP9B	XP_011524265.1	PhoLip_ATPase_N	125..182	CDD:292826	21/51 (41%)
		ATPase-Plipid	132..1169	CDD:273734	359/1434 (25%)
		E1-E2_ATPase	224..427	CDD:278548	68/241 (28%)
		Cation_ATPase	579..661	CDD:289987	29/104 (28%)
		HAD_like	<881..922	CDD:304363	22/40 (55%)
		PhoLip_ATPase_C	927..1166	CDD:292829	65/268 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930