Protein Alignment ATP8B and atp11c

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_009289452.1
• Gene: atp11c / 368385
• ZFINID: ZDB-GENE-030616-51
• Length: 1139
• Species: Danio rerio
• Alignment Length: 1500
• Identity: 419/1500 - (27%)
• Similarity: 658/1500 - (43%)
• Gaps: 456/1500 - (30%)

  Fly   182 RRRSSYYFSENERRIRAN----------DKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRL 236
            |||.:.....:|||:.:.          |.|.....|:.:|.|.:|||:::.|||.||.|||:|:
Zfish     3 RRRLNRLCGGDERRVDSRTIYVGHRPCPDTEAFIPPKFCDNRIVSSKYTVWNFLPKNLFEQFRRI 67

  Fly   237 ANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNG 301
            ||||||.:.::|:| ..:..:|||:.:||..|:|:||:|..|:|..||.:|::||......|.:|
Zfish    68 ANFYFLIIFLVQVI-VDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHKADNEVNKYPVTVLEDG 131

  Fly   302 KLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAK--------- 357
            :.|:.:..:::||||:.:..::....|.:||.:|..:|.||:.||.||||:|.|..
Zfish   132 RSVKKESEKIKVGDVVEVVEDETFPCDLILLQSSREDGTCFVTTASLDGESNHKTHYTVPDIERD 196

  Fly   358 -QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL-IWRGQR----FALDNEKILLRGCV 416
             |.||..||                ||:|...|.||.|.: |::.::    .:|..|.:||:|..
Zfish   197 LQVLTAAIE----------------CEQPQPDLYKFVGRMHIYKPEQEEAVRSLGPENLLLKGAT 245

  Fly   417 LRNTQWCYGVVVFAGVDTKLMQN-SGKTQFKSTGVDRLLNFIIIGIVLFLVSICALF--AIGCA- 477
            |:||:..|||.|:.|::||:..| .||:| |.:.|::.:|      ...||.:|.|.  |:.|.
Zfish   246 LKNTKEIYGVAVYTGMETKMALNYQGKSQ-KRSAVEKSIN------AFLLVYLCILISKAVVCTT 303

  Fly   478 ---IWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFV 539
               :|:...||.    .||.:...:....|...:.....|.|:.::.|.::|:|:||:||:.:|:
Zfish   304 LKYVWQSKEGQD----EPWYNEKTQKEKETNMYLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFL 364

  Fly   540 QSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDV 604
            .||.|.||.:.:.|.....|...|:.|||||||::|:|:|||||||||.|.|.:|.|:|..|.
Zfish   365 GSFFIKWDNDFFDPEIEEGALVNTSDLNEELGQVEYVFTDKTGTLTQNNMEFIECCIDGFQYR-- 427

  Fly   605 IDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSG 669
                                                           |: :.|.:.....||
Zfish   428 -----------------------------------------------HR-DAHGELDGFTVT--- 441

  Fly   670 EAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNE 734
                  |.|.:.::         ||                   |||
Zfish   442 ------DGPLNKLQ---------EK-------------------AGR------------------ 454

  Fly   735 ERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTA 799
                                                                             
Zfish   455 ----------------------------------------------------------------- 454

  Fly   800 TLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDF 864
                                                                             
Zfish   455 ----------------------------------------------------------------- 454

  Fly   865 RWYDRTLLDAVRSDEEHSHVFFRLLALCHTV------MAETVDG------KLE----YQAQSPDE 913
                           |...:|.|.|.|||||      :::.:||      |.|    :.|.||||
Zfish   455 ---------------EKEELFLRALCLCHTVQVKEETLSDQIDGIDGVLPKAEEERGFIASSPDE 504

  Fly   914 AALVSAARNFGFVFRTRTPNSITI-EVMGQTEEYELLNILDFNNVRKRMSVIL--RRGDSMVLYC 975
            .|||..|..:||.|......::.| ......|||:||::|:|:.||:|||||:  :.||:: |:|
Zfish   505 VALVKGAMEYGFTFLGLENKNMKIRNRQNDIEEYKLLHVLNFDPVRRRMSVIVQTKSGDTL-LFC 568

  Fly   976 KGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDS 1040
            ||||:.|:.|:...:.|   |.:.|:.:.|.:|.|||.:|.::|:.:.|....:..:||.|::..
Zfish   569 KGADSSIFPRVRPEEVD---RIRLHVERNATDGYRTLCVAYKQLSAEEYALADTGLREARLALQD 630

  Fly  1041 REQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQ 1105
            ||:||.|:|.::|:.|.|:|.||:||:||:...:::..||.||:|||||||||.|||.:..|:|:
Zfish   631 REEKLMAMYNQVETGMSLIGATAVEDRLQEEAAETMEALQGAGMKIWVLTGDKMETAKSTCYACR 695

  Fly  1106 LL---TD--ELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVT 1165
            |.   |:  ||....:.||.|     |:..:..|.::.|:|          |...|:
Zfish   696 LFQRGTELLELTVRTLEDGRS-----KREDRLLELLRDYHR----------RAVQDA-------- 737

  Fly  1166 MTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIV 1230
                              ||....|||..|
Zfish   738 ------------------PPVKTGVVTRSW----------------------------------- 749

  Fly  1231 VDENTGFALVVNGHSLVHCLSPELE-------NKFLDIASQCKAVICCRVTPLQKALVVELIKRA 1288
             ..|..:..:::|.:|...::|..:       ..||.|...|.||:|||:.|||||.:|:::|..
Zfish   750 -SANQEYGFIIDGATLSLVMNPPRDADASLYRGLFLQICQNCTAVLCCRMAPLQKAQIVKMVKNC 813

  Fly  1289 KNA-VTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            |.: :||:|||||||||||..||:|:||.|:||.|||.:|||:|.:.::|::|||.||...|.|:
Zfish   814 KGSPITLSIGDGANDVSMILEAHVGIGIKGKEGRQAVRNSDYAIPKLKHLKKLLLAHGHLYYVRI 878

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ...::||||||..|.|....|..|||:|.|.::|..::::||:.:||:|:||..:.||.::.:..
Zfish   879 AHLVQYFFYKNLCFILPQFLYQFFCGYSQQPLYDAAYLTMYNICFTSMPILAYSLLEQHIAIEIL 943

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGV----YKDGVSANGFVVSDHMTLG 1478
            |:...||....|:.:...|.|:|..:.|.|..|:.|   :||    ....:..||.|.. :.:.|
Zfish   944 LDNATLYREIAKNAMLRWRPFLYWTVLGIFQGLLFF---FGVRFLFSNPALQDNGQVFG-NWSYG 1004

  Fly  1479 AVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQA 1537
            .:|.|:|:...|.:::|.|.:||.:||..|||||.:|....:|:..:| .|::..      ....
Zfish  1005 TIVFTVLVFTVTLKLALDTRHWTWINHFVIWGSLAFYVFFSFFWGGII-WPFLKQQRLYFVFANM 1068

  Fly  1538 MKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR----ASSDVRRTASS 1598
            :..::.|:.::|.:             ||.:.|.:...:.:|. |..|||    ..|:|....||
Zfish  1069 LSSVSAWLVIIILI-------------LLSLLPEILLAVLRKP-KGPHSRQKKPGQSNVGGIPSS 1119

  Fly  1599 RRGRR 1603
            :...|
Zfish  1120 QSSAR 1124

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	27/74 (36%)
		Cation_ATPase	891..985	CDD:289987	45/112 (40%)
		HAD_like	<1261..1324	CDD:304363	37/63 (59%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	77/256 (30%)
atp11c	XP_009289452.1	PhoLip_ATPase_N	31..90	CDD:292826	26/59 (44%)
		ATPase-Plipid	40..1075	CDD:273734	395/1398 (28%)
		Cation_ATPase	466..578	CDD:289987	45/112 (40%)
		HAD_like	<819..850	CDD:304363	22/30 (73%)
		PhoLip_ATPase_C	850..1075	CDD:292829	73/229 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.720