DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP8A

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_001137651.1 Gene:ATP8A / 36488 FlyBaseID:FBgn0259221 Length:1350 Species:Drosophila melanogaster


Alignment Length:1760 Identity:522/1760 - (29%)
Similarity:781/1760 - (44%) Gaps:512/1760 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    41 RTPTKGAGNVDEP-GIEAPEASCSAPSKRTR----------WFQFA---------RSSKNRRKRL 85
            |:|..  |:||:| |........||..:|.:          ||:.:         .|.::...|.
  Fly    13 RSPDH--GSVDDPDGCLRNHLGSSASQRRRQQRIAQQRQDSWFRHSMPPAINRDFESLEHLTPRA 75

  Fly    86 HCNEDEDVKQPERRNSDLEGSPRACLAQPE---------GMNIG-SSTQTIATPLMIGDSFYSLA 140
            ....||.:......:....||...| ..|:         ..|:| ..:.|..||         :.
  Fly    76 SDGLDEQLAASVSHSVHSGGSVTLC-GPPDHSSIHLNSANSNLGFIDSDTPNTP---------VT 130

  Fly   141 PGGGNPPP---NKSDDQELYKQRDPSVTSESK-------------SVPSLRRL----SQIRRRRS 185
            |..|..||   :.|....|..:|..|...:||             |:.:.|.|    |.:||:|:
  Fly   131 PVSGLQPPASVSTSVGGTLSSRRRSSNRKDSKGSILSRQSGKSRVSLLAQRGLRMTASFLRRKRT 195

  Fly   186 SYYFSEN------------ERR-IRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLA 237
            .|...|:            ||| |..|..:   ..||.||.|.|:|||..:|||..|.|||:|.:
  Fly   196 EYEDDEDFTSSAGYDADDGERRIINLNGPQ---PTKYGNNRITTAKYSFISFLPAFLFEQFRRYS 257

  Fly   238 NFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGK 302
            |.:||.:.:||.||.:|.....||.:||:.:|:::|:|:..:||:||.:|:::|:|..:.|.:|.
  Fly   258 NCFFLLIAILQQIPEVSPTGRYTTLVPLMFILSVSAIKEIIEDIKRHRADNEINHRSIERLDSGS 322

  Fly   303 LVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELG 367
            ....:|||:.|||:|::..|.|..||.:|||:|||..:||||||.||||||||.:|.|..|.||.
  Fly   323 WCTVRWSELTVGDIIKVGINTFFPADLILLSSSEPQAMCFIETANLDGETNLKIRQALPATAELL 387

  Fly   368 DRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFALDNEKILLRGCVLRNTQWCYGVVVFAG 431
            :..| |....|.|.||.||..|.:|:|.|...|: ..||.|:::|.||.:||||.|.:|:||::|
  Fly   388 ETKD-LQRLEGRIECELPNRHLYEFNGVLRETGKPPAALGNDQVLQRGAILRNTAWVFGIVVYSG 451

  Fly   432 VDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHI 496
            .:||||:||.....|.:.||:|.|..|:.:.:.|:|:|.:..:....|..            ||.
  Fly   452 QETKLMKNSTSAPLKRSTVDKLTNTQILMLFMILISLCIISGLCNLFWTR------------EHS 504

  Fly   497 IPKDYI-----PTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTN 556
            ....|:     .|.:....||.||   |:.|.::||||.|::|::||:|:..||:|.|||:..:|
  Fly   505 ETDWYLGLTDFKTKSLGYNLLTFF---ILYNNLIPISLQVTLELVRFLQAIFINYDIEMYHEESN 566

  Fly   557 TYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTI 621
            |.|.|||:.||||||.::|||||||||||||:|.|.||||.|..|              |.::| 
  Fly   567 TPAMARTSNLNEELGMVKYIFSDKTGTLTQNVMEFKKCSIAGYVY--------------TAERT- 616

  Fly   622 FQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSA 686
                                                                             
  Fly   617 ----------------------------------------------------------------- 616

  Fly   687 PPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQ 751
                               |..||                                      .:|
  Fly   617 -------------------PEESQ--------------------------------------LVQ 624

  Fly   752 RQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEP 816
            ..|.|                     |.:|                     .||.:         
  Fly   625 NILGR---------------------HETS---------------------AVIEE--------- 638

  Fly   817 QSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEH 881
                                                                             
  Fly   639 ----------------------------------------------------------------- 638

  Fly   882 SHVFFRLLALCHTVMAETVD-GKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEE 945
               |..||::||||:.|..: |.:.|.|.||||.|||..|:.||::|.||||..:.|..:|..:.
  Fly   639 ---FLELLSVCHTVIPERKENGNMIYHAASPDERALVEGAQKFGYIFDTRTPKYVEINALGVRKR 700

  Fly   946 YELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGL 1009
            ||:||:|:|.:.|||||:|:|..::.: |:|||||.|||:||....:..:.:|..||.:||.:||
  Fly   701 YEVLNVLEFTSSRKRMSLIVRTPENKIKLFCKGADTVIYERLAPQGQAFREQTLRHLEEFASDGL 765

  Fly  1010 RTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPK 1074
            |||.||...:....|.:|.....:|::::.:||.||......||:.::|:|.|||||:||||||:
  Fly   766 RTLCLAVADIRPDVYQEWSQTFDKASVALQNRESKLEDAANLIENNLRLLGATAIEDRLQDGVPE 830

  Fly  1075 SIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIY 1139
            :||:|.:|||.|||||||||||||||||||:|::..: |:.|::..|::...:.:.:.      |
  Fly   831 TIASLLDAGIYIWVLTGDKQETAINIGYSCRLISHSM-DIIILNEESLDATREVIHRH------Y 888

  Fly  1140 NRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKG 1204
            ..|:                                                             
  Fly   889 GEFK------------------------------------------------------------- 892

  Fly  1205 GPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVI 1269
                                  :|...|.|.  |||::|.:|.:.||.:|.|.|.|:...|:.||
  Fly   893 ----------------------SSSAKDANV--ALVIDGTTLKYALSCDLRNDFQDLCILCRVVI 933

  Fly  1270 CCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQF 1334
            ||||:|:|||.|||::.::.||||||||||||||:||:.|::|:||||.|||||..:||||||||
  Fly   934 CCRVSPMQKAEVVEMVTQSTNAVTLAIGDGANDVAMIQKANVGIGISGVEGLQAACASDYSIAQF 998

  Fly  1335 RYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTS 1399
            |||:|||||||.|:|.|:.|.:.|.||||....:...|::::.|:|.|.:|:...|.:||:.:|:
  Fly   999 RYLQRLLLVHGAWNYARISKLILYSFYKNVCLYVIELWFAVYSGWSGQILFERWTIGLYNVLFTA 1063

  Fly  1400 LPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGV 1464
            :|..|:|:||:..:.:..:.:|.||.....::|||::.|...:.:....|:.||.:|...|...|
  Fly  1064 MPPFAMGLFEKFCTAETMIRYPMLYKTSQNAKLFNVKVFWIWIFNALLHSVFLFWLPLAAYTKEV 1128

  Fly  1465 SANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYV---- 1525
            ..:....||::.:|.:|.|.:||....:..|.|:.||.:.|:.||||:|.:|.....|::|    
  Fly  1129 IWSDGKTSDYLLMGNLVYTYVIVTVCLKAGLITNSWTWLTHLAIWGSIVLWFGFLLIYSHVWPMF 1193

  Fly  1526 -IGGPYVGSLTQAMKDLTFW-VTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRA 1588
             ....:.|...|.:....|: ..||:.:..|:..|:. |.....|..:|::.:|:..:::     
  Fly  1194 KFASNFRGMDIQLLSTPVFYFCLMLVPITTLLIDVIC-KLVHNTVFKTLTEAVRETEIRR----- 1252

  Fly  1589 SSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNLN 1653
             ||:....:.   .||..||:.:|    .|:||.|..|:                   :.|:   
  Fly  1253 -SDISEVMNE---PRSSDSGFGYA----LGKLIRSSHIL-------------------ISHD--- 1287

  Fly  1654 SADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSSMADITADGRG------NGGDDGRGSGGSDDM 1712
                          ||.|:.::...:.:.:|....||.....:.      .||....|...|...
  Fly  1288 --------------HHPVSESSRTSNLRVENLEMEADTEQQQQSRQRQKWRGGQVATGVARSARN 1338

  Fly  1713 SPRAP 1717
            |..:|
  Fly  1339 STTSP 1343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 28/65 (43%)
Cation_ATPase 891..985 CDD:289987 47/95 (49%)
HAD_like <1261..1324 CDD:304363 40/62 (65%)
PhoLip_ATPase_C 1324..1571 CDD:292829 83/252 (33%)
ATP8ANP_001137651.1 PhoLip_ATPase_N 218..280 CDD:292826 27/64 (42%)
ATPase-Plipid 229..1247 CDD:273734 446/1382 (32%)
E1-E2_ATPase 286..>371 CDD:278548 37/84 (44%)
Cation_ATPase 645..741 CDD:289987 47/95 (49%)
HAD_like <942..1001 CDD:304363 41/58 (71%)
PhoLip_ATPase_C 988..1240 CDD:292829 83/252 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45445304
Domainoid 1 1.000 92 1.000 Domainoid score I1716
eggNOG 1 0.900 - - E2759_KOG0206
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D11922at33392
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - P PTHR24092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
98.750

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