DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp11b

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_038959540.1	Gene:	Atp11b / 361929	RGDID:	1561719	Length:	1175	Species:	Rattus norvegicus

Alignment Length:	1469	Identity:	417/1469 - (28%)
Similarity:	669/1469 - (45%)	Gaps:	412/1469 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 GNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFK 208
            |..||::||.:.:|                      |..|     |.:|..        :..| |
  Rat    10 GFDPPHQSDTRTIY----------------------IANR-----FPQNGL--------YTPQ-K 38

  Fly   209 YHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTLT 272
            :.:|.|.:|||:::.|:|.||.|||:|:||||||.:.::||:  |.:.| |:|:.:||..|:|:|
  Rat    39 FIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLM--IDTPTSPITSGLPLFFVITVT 101

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.||::||......:|:|.||:.:...::|||::|:..::...||.:|||:...
  Rat   102 AIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRL 166

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEII---CERPNNLLNKFDGTLIWR 399
            :|.|.:.||.||||||||....:.||..|    .::.|.:..|.   |::|...|.:|.|.:|..
  Rat   167 DGSCHVTTASLDGETNLKTHVSVPETAVL----QTVANLDSLIAVIECQQPEADLYRFMGRMIIT 227

  Fly   400 GQR----FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIG 460
            .|.    ..|..|.:||||..|:||:..:||.|:.|::||:..|......|.:.|::.:|..:|.
  Rat   228 QQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLII 292

  Fly   461 IVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVV 525
            .::.|:|...:..|....|:.    ..:...||.:...:....:...:..:..|.::.::.|.::
  Rat   293 YLIILISEAIISTILKYTWQA----EEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFII 353

  Fly   526 PISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMT 590
            ||||||:||:.:|:.||.|.||.::|:..::..|:..|:.|||||||::|:|:|||||||:|.|.
  Rat   354 PISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQ 418

  Fly   591 FNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAE 655
            |.:|||||..|.::    .|:||                            |..|.|
  Rat   419 FRECSINGLKYQEI----NGKLV----------------------------PEGPSP-------- 443

  Fly   656 VHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPR 720

  Rat   444 ----------------------------------------------------------------- 443

  Fly   721 LDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRK 785
             |.:.|..|.:|
  Rat   444 -DSAEGNDPYLG----------------------------------------------------- 454

  Fly   786 RLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQ 850
                                            |.|.||::.|                     |.
  Rat   455 --------------------------------SLSHLSSSAH---------------------LT 466

  Fly   851 SVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV------DG------- 902
            :.....:|..|::.             .:||. :||:.::|||||....|      ||
  Rat   467 ATSLRTSPESETEL-------------IKEHD-LFFKAVSLCHTVQISNVQTDGIGDGPWQPNLA 517

  Fly   903 --KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVIL 965
              :|||.|.||||.|||.||...|.:|...:..::.::|:|:.|.|:||:||:|::.|:|||||:
  Rat   518 PTQLEYYASSPDEKALVEAAARAGIIFIGISEETMEVKVLGRVERYKLLHILEFDSDRRRMSVIV 582

  Fly   966 R--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWR 1028
            :  .|:.: |:.|||::.|..:..||:   .|:|:.|:::||.:|||||.:|.|:.|.:.|.|..
  Rat   583 QAPSGEKL-LFAKGAESSILPKCIGGE---IAKTRIHVDEFALKGLRTLCIAYRQFTAEEYEDVN 643

  Fly  1029 SRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDK 1093
            .|..||..|:..||:||..:::.||.::.|:|.||:||:|||.|.::|..|:.||||:|||||||
  Rat   644 RRLFEARTSLQRREEKLAGVFQYIEKDLVLLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDK 708

  Fly  1094 QETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSN 1158
            .|||:::..||......:..:.:::..|.....:||||....|
  Rat   709 HETAVSVSLSCGHFHRTMNILELINQKSDSGCAEQLRQLARRI---------------------- 751

  Fly  1159 MDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSED 1223

  Rat   752 ----------------------------------------------------------------- 751

  Fly  1224 GGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK-R 1287
              |...|:..    .|||:|.||...|. |.|..|:::...|.||:|||:.|||||.|:.||| .
  Rat   752 --TEDHVIQH----GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKIS 809

  Fly  1288 AKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            .:..:|||:||||||||||:.||:|:||.|:||.||..:|||::|:|::|.:||.|||.:.|.|:
  Rat   810 PEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAVARFKFLSKLLFVHGHFYYIRI 874

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ...::||||||..|......|..:|.||.||::|.:::::||:.:||||||...:.||.:.....
  Rat   875 ATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPVLIYSLLEQHIDPHVL 939

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY----KD-GVSANGFVVSDHMTL 1477
            ...|.||....|:.|.:::.|:|..:.|...:.:.|   :|.|    || .:..||.:.. :.|.
  Rat   940 QSKPTLYRDISKNRLLSMKAFLYWTVLGFSHAFIFF---FGSYFLIGKDTSLLGNGQMFG-NWTF 1000

  Fly  1478 GAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQ 1536
            |.:|.|::::..|.:::|.|.:||.:||:..|||:::||:...||..:: .|::||      ..|
  Rat  1001 GTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFIFSLFYGGIL-WPFLGSQNMYSVFIQ 1064

  Fly  1537 AMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDK 1575
            .:...:.|..:|:.|::.:...:..|.:...:||:.:.|
  Rat  1065 LLSSGSAWFAILLMVVSCLFVDVVKKVFDRQLHPTSTQK 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/65 (40%)
		Cation_ATPase	891..985	CDD:289987	44/110 (40%)
		HAD_like	<1261..1324	CDD:304363	37/63 (59%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	79/257 (31%)
Atp11b	XP_038959540.1	P-type_ATPase_APLT_Dnf-like	41..978	CDD:319770	370/1273 (29%)
Atp11b	XP_038959540.1	AA_permease_2	<959..>1085	CDD:424363	35/130 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820