Protein Alignment ATP8B and Atp11b

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001413956.1
• Gene: Atp11b / 361929
• RGDID: 1561719
• Length: 1175
• Species: Rattus norvegicus
• Alignment Length: 1469
• Identity: 417/1469 - (28%)
• Similarity: 669/1469 - (45%)
• Gaps: 412/1469 - (28%)

  Fly   144 GNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFK 208
            |..||::||.:.:|                      |..|     |.:|..        :..| |
  Rat    10 GFDPPHQSDTRTIY----------------------IANR-----FPQNGL--------YTPQ-K 38

  Fly   209 YHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTLT 272
            :.:|.|.:|||:::.|:|.||.|||:|:||||||.:.::||:  |.:.| |:|:.:||..|:|:|
  Rat    39 FIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLM--IDTPTSPITSGLPLFFVITVT 101

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.||::||......:|:|.||:.:...::|||::|:..::...||.:|||:...
  Rat   102 AIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRL 166

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEII---CERPNNLLNKFDGTLIWR 399
            :|.|.:.||.||||||||....:.||..|    .::.|.:..|.   |::|...|.:|.|.:|..
  Rat   167 DGSCHVTTASLDGETNLKTHVSVPETAVL----QTVANLDSLIAVIECQQPEADLYRFMGRMIIT 227

  Fly   400 GQR----FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIG 460
            .|.    ..|..|.:||||..|:||:..:||.|:.|::||:..|......|.:.|::.:|..:|.
  Rat   228 QQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLII 292

  Fly   461 IVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVV 525
            .::.|:|...:..|....|:.    ..:...||.:...:....:...:..:..|.::.::.|.::
  Rat   293 YLIILISEAIISTILKYTWQA----EEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFII 353

  Fly   526 PISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMT 590
            ||||||:||:.:|:.||.|.||.::|:..::..|:..|:.|||||||::|:|:|||||||:|.|.
  Rat   354 PISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQ 418

  Fly   591 FNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAE 655
            |.:|||||..|.::    .|:||                            |..|.|
  Rat   419 FRECSINGLKYQEI----NGKLV----------------------------PEGPSP-------- 443

  Fly   656 VHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPR 720
                                                                             
  Rat   444 ----------------------------------------------------------------- 443

  Fly   721 LDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRK 785
             |.:.|..|.:|
  Rat   444 -DSAEGNDPYLG----------------------------------------------------- 454

  Fly   786 RLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQ 850
                                            |.|.||::.|                     |.
  Rat   455 --------------------------------SLSHLSSSAH---------------------LT 466

  Fly   851 SVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV------DG------- 902
            :.....:|..|::.             .:||. :||:.::|||||....|      ||
  Rat   467 ATSLRTSPESETEL-------------IKEHD-LFFKAVSLCHTVQISNVQTDGIGDGPWQPNLA 517

  Fly   903 --KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVIL 965
              :|||.|.||||.|||.||...|.:|...:..::.::|:|:.|.|:||:||:|::.|:|||||:
  Rat   518 PTQLEYYASSPDEKALVEAAARAGIIFIGISEETMEVKVLGRVERYKLLHILEFDSDRRRMSVIV 582

  Fly   966 R--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWR 1028
            :  .|:.: |:.|||::.|..:..||:   .|:|:.|:::||.:|||||.:|.|:.|.:.|.|..
  Rat   583 QAPSGEKL-LFAKGAESSILPKCIGGE---IAKTRIHVDEFALKGLRTLCIAYRQFTAEEYEDVN 643

  Fly  1029 SRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDK 1093
            .|..||..|:..||:||..:::.||.::.|:|.||:||:|||.|.::|..|:.||||:|||||||
  Rat   644 RRLFEARTSLQRREEKLAGVFQYIEKDLVLLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDK 708

  Fly  1094 QETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSN 1158
            .|||:::..||......:..:.:::..|.....:||||....|
  Rat   709 HETAVSVSLSCGHFHRTMNILELINQKSDSGCAEQLRQLARRI---------------------- 751

  Fly  1159 MDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSED 1223
                                                                             
  Rat   752 ----------------------------------------------------------------- 751

  Fly  1224 GGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK-R 1287
              |...|:..    .|||:|.||...|. |.|..|:::...|.||:|||:.|||||.|:.||| .
  Rat   752 --TEDHVIQH----GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKIS 809

  Fly  1288 AKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            .:..:|||:||||||||||:.||:|:||.|:||.||..:|||::|:|::|.:||.|||.:.|.|:
  Rat   810 PEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAVARFKFLSKLLFVHGHFYYIRI 874

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ...::||||||..|......|..:|.||.||::|.:::::||:.:||||||...:.||.:.....
  Rat   875 ATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPVLIYSLLEQHIDPHVL 939

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY----KD-GVSANGFVVSDHMTL 1477
            ...|.||....|:.|.:::.|:|..:.|...:.:.|   :|.|    || .:..||.:.. :.|.
  Rat   940 QSKPTLYRDISKNRLLSMKAFLYWTVLGFSHAFIFF---FGSYFLIGKDTSLLGNGQMFG-NWTF 1000

  Fly  1478 GAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQ 1536
            |.:|.|::::..|.:::|.|.:||.:||:..|||:::||:...||..:: .|::||      ..|
  Rat  1001 GTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFIFSLFYGGIL-WPFLGSQNMYSVFIQ 1064

  Fly  1537 AMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDK 1575
            .:...:.|..:|:.|::.:...:..|.:...:||:.:.|
  Rat  1065 LLSSGSAWFAILLMVVSCLFVDVVKKVFDRQLHPTSTQK 1103

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	146/398 (37%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	203/588 (35%)
Atp11b	NP_001413956.1	None