Protein Alignment ATP8B and Atp10d

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001414735.1
• Gene: Atp10d / 360932
• RGDID: 1588541
• Length: 1417
• Species: Rattus norvegicus
• Alignment Length: 1513
• Identity: 467/1513 - (30%)
• Similarity: 718/1513 - (47%)
• Gaps: 324/1513 - (21%)

  Fly   209 YHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTA 273
            |.||.|:|:||:|..|:|.||.|||.|.||.|||.|:||..:|.:.:.....|.:||:.|||:.|
  Rat    71 YVNNRIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIA 135

  Fly   274 VKDAYDDIQRHISDSQVNN-------RKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLL 331
            :||..:|.:::..|.|:||       ||.|     |.::..|..|.|||.|||..|:.:.||.:|
  Rat   136 IKDGLEDYRKYKIDKQINNLITKVYSRKEK-----KYIDCCWKNVTVGDFIRLSCNEIIPADMVL 195

  Fly   332 LSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL 396
            |.:::|:|:|.|||:.||||:|||.:|.:....|.....|. ..|:..|.||.|||.|::|.|.|
  Rat   196 LFSTDPDGICHIETSGLDGESNLKQRQVVRGYAEQDSEVDP-EKFSSRIECESPNNDLSRFRGFL 259

  Fly   397 IWRG-QRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIG 460
            .... :|..|..|.:|||||.:|||:...|:||:||.:||.|.|:...::|.:.::|..|..::.
  Rat   260 EHSNKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRANTDVLW 324

  Fly   461 IVLFLVSICALFAIGCAIW----EGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVL 521
            .||.|:.:|...|:|..||    |.::  .|.:..|...::       ...:.|..||::..|:|
  Rat   325 CVLLLIVMCLTGALGHGIWLSRYENML--FFNIPEPDGRVL-------SPVLTGFYVFWTMIILL 380

  Fly   522 NTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQ 586
            ..::|||||||:|:::..|.:.|..|.|.|....::..:.|...:.|:||||||:|||||||||:
  Rat   381 QVLIPISLYVSIEIVKLGQIYFIQSDVEFYNEKMDSTIQCRALNITEDLGQIQYLFSDKTGTLTE 445

  Fly   587 NIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILV 651
            |.|.|.:||:.|..|   ......:.:|..::....:...|:.....||...||.|.|.
  Rat   446 NKMVFRRCSVAGFDY---CHEENAKRLESYQEAVSEEEECTDTLSGSLSLGSVARPRAQ------ 501

  Fly   652 HKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADA-- 714
            .....|::              ||.:|.:.:..|...:...|....:.|.|.:|.|...:.|.
  Rat   502 SCRTAHSR--------------LPGKPLAQLSGSTSAVGNGEGSGEVLHSRQAAFSSPIETDVVP 552

  Fly   715 --------GRLSP----RLDGSGGLSP---------------------PVGNEERRISGGFKRSG 746
                    .:::|    ||||:...:|                     ...|:.|:..|   .|.
  Rat   553 DTRLLDKFSQITPQLFTRLDGAAQSAPLETLYIMDFFIALAICNTVVVSAPNQPRQKIG---LSS 614

  Fly   747 AGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTAT----------- 800
            .|.|.     ..|.:::|                  |..:.:.:|...:||.|:
  Rat   615 LGGMP-----IKSLEEIK------------------NIFQKLSVRRSSSPSLASGKDSTSGTPCA 656

  Fly   801 ------------LGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVD 853
                        |...:......:||.||::::...|:
  Rat   657 FVSRISFFSRTKLSPPVEDESSQMDEIPQASNSACCTE--------------------------- 694

  Fly   854 FSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDG------KLEYQAQSPD 912
                                   |:.|:|.|...:.:      ||.:||      .|.|:|:|||
  Rat   695 -----------------------SEAENSDVGLPIDS------AEALDGPPPLASNLCYEAESPD 730

  Fly   913 EAALVSAARNFGFVFRTRTPNSITIE--VMGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVL 973
            |||||.|||.:....|:|||..:.::  .:|.. .::||:||.|::|||||||::|.  ...:|:
  Rat   731 EAALVYAARAYHCTLRSRTPEQVVVDFAALGPL-TFQLLHILPFDSVRKRMSVVVRHPLSKQVVV 794

  Fly   974 YCKGADNVIYDRLHGGQED----------LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWR 1028
            |.||||:||.:.|.....|          ::.|||.||:::|..|||||.:|::.:::..|.:|.
  Rat   795 YTKGADSVIMELLSVASSDGTNLEDQQMVIRERTQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWL 859

  Fly  1029 SRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDK 1093
            .....|..|:|:||:.|......:|:::.|:|.|.|||:||:|||:||..|..||||||:|||||
  Rat   860 RNHFLAETSIDNREELLVESAMRLENKLTLLGATGIEDRLQEGVPESIEALHKAGIKIWMLTGDK 924

  Fly  1094 QETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDR---LNS 1155
            ||||:||.|:|:||                                        :|.|:   ||:
  Rat   925 QETAVNIAYACKLL----------------------------------------EPDDKLFILNT 949

  Fly  1156 DSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKG 1220
            .|. |...:.|   ||.::|.                      .|..:..|:.|.....|.....
  Rat   950 QSE-DACGMLM---SAILEEL----------------------QKRTQVSPELASPRKNFPQPPD 988

  Fly  1221 SEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELI 1285
            .:..|.|          .||:.|.:|...|...|:.:||::.:.|:||||||.|||||:.||:|:
  Rat   989 PQVPGRA----------GLVITGKTLEFALQESLQKQFLELTAWCQAVICCRATPLQKSEVVKLV 1043

  Fly  1286 KRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYY 1350
            :...:.:||||||||||||||:.|.||:|:|||||:|||::||::|:|||:|.:||||||.|.|.
  Rat  1044 RNHLHVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAISQFRHLSKLLLVHGHWCYT 1108

  Fly  1351 RMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDK 1415
            |:...:.||||||.|:.....||..|||||..::.|...:..:||.:||:|.:..||.|:|||.:
  Rat  1109 RLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSVPPIIYGVLEKDVSAE 1173

  Fly  1416 NSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAV 1480
            ..|:.|.||..|.:||.:....|..::|...:.|||.|.:||..|: |...:.|...:.:...|:
  Rat  1174 TLLQLPELYQSGQRSEEYLPLTFWITLLDAFYQSLVCFFVPYFTYQ-GSDIDIFTFGNPLNTAAL 1237

  Fly  1481 VATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIG----------GPYVGSLT 1535
            :..:|      .:.:.:...|.::.:.|.||::.||    |:....|          .|| |.:.
  Rat  1238 LIILL------HLVIESKSLTWIHMLVIVGSILSYF----FFALAFGALCVTCNPPSNPY-GIMQ 1291

  Fly  1536 QAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPS----------LSDKIRQKSLKKIHSRASS 1590
            :.|.|..|::..::|....:.|...|:.....|.||          ||.:.|.::||:  .|.::
  Rat  1292 KHMLDPVFYLVCVLTTCVALLPRFVYRVLQGSVFPSPILRAKYFDRLSPEERAEALKR--WRGTA 1354

  Fly  1591 DVRRTASSRRGRRSVRSG 1608
            .|...||....:.:.:||
  Rat  1355 KVNHVASKYASQSAAKSG 1372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	157/402 (39%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	222/593 (37%)
Atp10d	NP_001414735.1	None