DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp11c

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_001032952.1	Gene:	Atp11c / 320940	MGIID:	1859661	Length:	1129	Species:	Mus musculus

Alignment Length:	1428	Identity:	405/1428 - (28%)
Similarity:	652/1428 - (45%)	Gaps:	380/1428 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            ::.:|.|.:|||:|:.|||.||.|||:|:||||||.:.::| :...:..:|||:.:||..|:|:|
Mouse    39 RFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVT 102

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.:|::||......:.|.|.|..:..:::||||:.:..|:....|.:|||:...
Mouse   103 AIKQGYEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTT 167

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL-IWRGQ 401
            :|.|::.||.||||:|.|....:.:||.|... :|:.|....|.||:|...|.:|.|.: |:...
Mouse   168 DGTCYVTTASLDGESNCKTHYAVRDTIALCTA-ESIDNLRATIECEQPQPDLYRFVGRISIYSNS 231

  Fly   402 RFA----LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN-SGKTQFKSTGVDRLLN-FIIIG 460
            ..|    |..|.:||:|..|:||:..|||.|:.|::||:..| .||:| |.:.|::.:| |:|:.
Mouse   232 IEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQ-KCSAVEKSINAFLIVY 295

  Fly   461 IVLFL--VSICALFAIGCAIWEGLIGQHFQLY--LPWEHIIPKDYIPTGATVIGLLVFFSYAIVL 521
            :.:.|  .::|.....   :|:.      ..|  .||.:...:....|...:.....|.|:.::.
Mouse   296 LFILLTKAAVCTTLKY---VWQS------SPYNDEPWYNQKTQKERETFQVLKMFTDFLSFMVLF 351

  Fly   522 NTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQ 586
            |.::|:|:||:||:.:|:.||.|:||::.:....|..|...|:.|||||||:.|:|:|||||||:
Mouse   352 NFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTE 416

  Fly   587 NIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILV 651
            |.|.|.:|.|:|..|
Mouse   417 NSMEFIECCIDGHKY-------------------------------------------------- 431

  Fly   652 HKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGR 716
                            .|..|
Mouse   432 ----------------KGTTQ-------------------------------------------- 436

  Fly   717 LSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSS 781
               .:||                              ||:|
Mouse   437 ---EVDG------------------------------LSQT------------------------ 444

  Fly   782 HNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRV 846

Mouse   445 ----------------------------------------------------------------- 444

  Fly   847 HALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAET---VDGKLE--- 905
                          :....::|       ::|:....:|.|.|.|||||..:|   |||.:|
Mouse   445 --------------DGPLAYFD-------KADKNREALFLRALCLCHTVEMKTNDDVDGPVEGAG 488

  Fly   906 --YQAQSPDEAALVSAARNFGFVFRTRTPNSITIE-VMGQTEEYELLNILDFNNVRKRMSVILR- 966
              |.:.||||.|||..|:.|||.|.......|.:| ...:.||||||:.|:|::||:|||||:|
Mouse   489 FTYISSSPDEIALVKGAKRFGFTFLGNQNGYIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRT 553

  Fly   967 -RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSR 1030
             :|| ::|:|||||:.|:.|:|..|.:|   |:||:.:.|.:|.|||.:|.:.:....:....::
Mouse   554 QKGD-ILLFCKGADSSIFPRVHSHQIEL---TKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQ 614

  Fly  1031 QQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQE 1095
            ..||.:::..||:||..:::|||:.|.|:|.||:||||||...::|..|..||:|:|||||||.|
Mouse   615 LVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKME 679

  Fly  1096 TAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMD 1160
            ||.:..|:|:|.... .::..:...::||.|:     ||                |||:
Mouse   680 TAKSTCYACRLFQTN-TELLELTTKTIEESER-----KE----------------DRLH------ 716

  Fly  1161 PLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGG 1225
              .:.:......:.|.        |.:...:...|.|..:              :|
Mouse   717 --ELLIEYRKKLLHEF--------PKSTRSLKKAWTEHQE--------------YG--------- 748

  Fly  1226 TASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKN 1290
               :::|.:| .:|::|  |...|.|...::.||.|..:|.||:|||:.|||||.:|.::|..|.
Mouse   749 ---LIIDGST-LSLILN--SSQDCSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKG 807

  Fly  1291 A-VTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCK 1354
            : :||:|||||||||||..:|:|:||.|:||.||..:||||:.:|::|::||||||...|.|:..
Mouse   808 SPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAH 872

  Fly  1355 FLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLE 1419
            .::||||||..|.|....|..|||||.|.::|..::::||:.:||||:||..:.||.::......
Mouse   873 LVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTA 937

  Fly  1420 FPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATI 1484
            .||||.....:.:..:..|::.....||...|.|...|.:::.....:...:..:.|.|.:|.|:
Mouse   938 DPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTV 1002

  Fly  1485 LIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQAMKDLTF 1543
            |:...|.:::|.|.:||.:||..|||||.:|....:|:..:| .|::..      ..|.:..::.
Mouse  1003 LVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGII-WPFLKQQRMYFVFAQMLCSVST 1066

  Fly  1544 WVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVR 1606
            |:.:::.:...:.|.:     ||         |..|::::..:|.:...||.:.|...|.|||
Mouse  1067 WLAIILLIFISLFPEI-----LL---------IVVKNVRRRSARRNLSCRRASDSLSARPSVR 1115

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/51 (45%)
		Cation_ATPase	891..985	CDD:289987	50/104 (48%)
		HAD_like	<1261..1324	CDD:304363	36/63 (57%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	76/252 (30%)
Atp11c	NP_001032952.1	P-type_ATPase_APLT_Dnf-like	42..974	CDD:319770	368/1267 (29%)
		Cyt_bd_oxida_II	<993..1083	CDD:376764	24/95 (25%)
		Di-leucine motif. /evidence=ECO:0000250\|UniProtKB:Q8NB49	1113..1118		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.720