Protein Alignment ATP8B and Atp8b5

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_006538058.1
• Gene: Atp8b5 / 320571
• MGIID: 2444287
• Length: 1195
• Species: Mus musculus
• Alignment Length: 1476
• Identity: 615/1476 - (41%)
• Similarity: 805/1476 - (54%)
• Gaps: 347/1476 - (23%)

  Fly   182 RRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLV 246
            ||.......|.||.::||::.||:.|:|.:|.||||||..|.|||.||.||||||||.|||.||.
Mouse    25 RRNEDRQKEEEERILQANNRRFNSLFEYPDNSIKTSKYGFFNFLPMNLFEQFQRLANAYFLILLF 89

  Fly   247 LQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI------------QRHISDSQVNNRKSKTLR 299
            |||:|.||||...||.||||.||::|.||||.||:            :||.||.|:|||....|.
Mouse    90 LQLVPQISSLAWYTTVIPLIVVLSITGVKDAIDDVVKWLPGLPSLDLKRHRSDQQINNRSVSILV 154

  Fly   300 NGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETI 364
            ||::.|.||..|||||:|:|:||..|.||.||||:|||.||.:||||:||||||||.||.::.|.
Mouse   155 NGRVEEIKWRNVQVGDIIKLENNHPVTADMLLLSSSEPYGLTYIETADLDGETNLKVKQAISVTS 219

  Fly   365 ELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVF 429
            .:.|..:.|.:||||:.|:.|||.|:||.|||.:.|..:.|::|::||||||:|||.||||:||:
Mouse   220 AMEDNLELLSSFNGEVRCDPPNNKLDKFSGTLSYLGNTYLLNHERLLLRGCVIRNTDWCYGLVVY 284

  Fly   430 AGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWE 494
            .|.|||||||||::.||.|.:|.|:|.:::.|.:||..:|.|.:||..|||...|.:||.:|||:
Mouse   285 TGQDTKLMQNSGRSTFKRTHIDHLMNVLVVWIFMFLGGMCFLLSIGHGIWENSRGYYFQAFLPWK 349

  Fly   495 HIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYA 559
            |     ||.:.|| ...|:|:||.|||||:||||||||||:||...|:.||||.:|:|...|..|
Mouse   350 H-----YITSSAT-SSALIFWSYFIVLNTMVPISLYVSVEIIRLGNSYYINWDRKMFYAPKNMPA 408

  Fly   560 KARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQN 624
            :||||||||||||:||:|||||||||:|:|.||||||||::||
Mouse   409 QARTTTLNEELGQVQYVFSDKTGTLTENVMIFNKCSINGKTYG---------------------- 451

  Fly   625 SNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPM 689
                                                                             
Mouse   452 ----------------------------------------------------------------- 451

  Fly   690 DASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQL 754
                         ||                .|.:|...|
Mouse   452 -------------YS----------------YDDNGEYVP------------------------- 462

  Fly   755 SRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQST 819
                                                   |:|.
Mouse   463 ---------------------------------------KSPK---------------------- 466

  Fly   820 STLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHV 884
                                          ..||||.|...:..|.:||:||::||:|::...::
Mouse   467 ------------------------------DKVDFSYNHLADPKFSFYDKTLVEAVKSEDPLVYL 501

  Fly   885 FFRLLALCHTVMA-ETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYEL 948
            ||..|:||||||: |.|:|:|.||||||||.|||:|.|||||||.:|||.:||:..||:...|.|
Mouse   502 FFLCLSLCHTVMSEEKVEGELVYQAQSPDEGALVTATRNFGFVFCSRTPETITVIEMGKIRVYRL 566

  Fly   949 LNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTL 1012
            |.||||:|.|||||||:|. .|.::|:|||||.:||:.||.....|...|.|||:.||.||||||
Mouse   567 LAILDFSNERKRMSVIVRTPEDRVMLFCKGADTIIYELLHPSCASLSEVTMDHLDDFASEGLRTL 631

  Fly  1013 ALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIA 1077
            .:|.|.|.:.|:..|..:..||.|::::||:||..:|||||.::.|:|.||||||||.|||::|.
Mouse   632 MVAYRELDKAYFQTWIKKHGEAWLTLENRERKLALVYEEIERDLMLLGATAIEDKLQRGVPETIV 696

  Fly  1078 NLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRF 1142
            .|..|.||||||||||||||:||.|||::..||:..||:|:|...|.|.::||..::.:|
Mouse   697 TLSKAKIKIWVLTGDKQETAVNIAYSCRIFKDEMDGVFMVEGTDRETVLEELRTARKKMK----- 756

  Fly  1143 RPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPD 1207
                  |...|.|    ||:::.:.:             .|..|..|
Mouse   757 ------PESLLES----DPINMYLAR-------------KPKMPFKS------------------ 780

  Fly  1208 SAECNNLFGDEKGSEDGGTASIVVDE--NTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVIC 1270
                                   :||  |..:.||::|:||.:.|...||.:.|..|..||.|:|
Mouse   781 -----------------------LDEVANGNYGLVISGYSLAYALEGSLEFELLRTACMCKGVVC 822

  Fly  1271 CRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFR 1335
            ||:||||||.||:|:||.|..|||||||||||:|||||||||||||.|||:||.||||:|..||.
Mouse   823 CRMTPLQKAQVVDLVKRYKKVVTLAIGDGANDISMIKAAHIGVGISNQEGMQATLSSDFSFCQFH 887

  Fly  1336 YLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSL 1400
            :|:||||||||.||.||||||.|||||||||||.|.||:.|.|||||||:|..||:.|||.||||
Mouse   888 FLQRLLLVHGRLSYNRMCKFLSYFFYKNFAFTLVHFWYAFFNGFSAQTVYDIWFITFYNLIYTSL 952

  Fly  1401 PVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVS 1465
            |||.|.:||:||::..||.:|.||.||..:..||.:||:..:|||.:.|.|||.:|.|...:...
Mouse   953 PVLGLSLFEKDVNETWSLCYPELYEPGQHNLYFNKKEFVKCLLHGIYNSFVLFFVPMGTVFNSER 1017

  Fly  1466 ANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYF-----------VLD 1519
            .:|..:||..:...:|.|.||...|.||:|.|:.||::||...||||..||           .|.
Mouse  1018 NDGKDISDFQSFSLLVQTTLIGVMTMQIALRTTSWTMINHTFTWGSLGLYFCILILLCSDGLCLR 1082

  Fly  1520 Y--FYNYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLK 1582
            |  .:|::  |....||:|..    .|:.::::.:..:.|::.|.|....:.|..:||:    |.
Mouse  1083 YPSIFNFL--GVARNSLSQPQ----IWLCLILSTILCMIPLIGYNFLRPLLWPINADKV----LN 1137

  Fly  1583 KIHSRASSDVRRTASSRRGRRSV-RSGYAFAHQEGFGRLITSGKIM 1627
            :||......:.....::....|: ||.|||:|::|||.||||||.:
Mouse  1138 RIHFCLKHPIPTQVQTKIKHPSLRRSAYAFSHKQGFGALITSGKTL 1183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	233/402 (58%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	292/574 (51%)
Atp8b5	XP_006538058.1	P-type_ATPase_APLT_Dnf-like	54..1008	CDD:319770	547/1260 (43%)