DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp10b

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_795973.2	Gene:	Atp10b / 319767	MGIID:	2442688	Length:	1474	Species:	Mus musculus

Alignment Length:	1576	Identity:	494/1576 - (31%)
Similarity:	771/1576 - (48%)	Gaps:	282/1576 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 YKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFK-----YHNNYIKT 216
            ::.:|....|.|::.|.|...:.    |.|:..:| :|.:..|:...:..:|     |..|.|.|
Mouse    14 WRTQDGFSQSPSETTPLLSPETD----RQSHNTAE-QRVVYPNNSMCHQDWKKVCRRYPGNSICT 73

  Fly   217 SKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI 281
            :||:|.||||.||.|||.|.||.|||.|::|..:|::.......|..||..||.:..|||..:|.
Mouse    74 TKYTLLTFLPQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITIFPLATVLLIIMVKDGIEDF 138

  Fly   282 QRHISDSQVNN-------RKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNG 339
            :|:..|.::|:       ||.:     :.:..:|.:|:|||.:::..|:.|.||.|||.:|:|:|
Mouse   139 KRYCFDREMNSASIQIYERKEQ-----RYMLKRWQDVRVGDFVQMQCNEIVPADILLLFSSDPSG 198

  Fly   340 LCFIETAELDGETNLKAKQCL----TETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRG 400
            :|.:|||.||||||||.::.:    ...::....|     |:..|:||:|||.|:||.|.:....
Mouse   199 VCHLETANLDGETNLKQRRVVKGFSQPEVQFQPEH-----FHSTIVCEKPNNHLSKFKGYMEHPD 258

  Fly   401 Q-RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGI 461
            | |....:|.:|||||.:|||:...|:|::||.:||.|.|:...::|.:.::|.:|   |..||:
Mouse   259 QTRTGFGSESLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGL 323

  Fly   462 VLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIP------TGATVIGLLVFFSYAIV 520
             |||  :|.:.|:|.::|.|...:|           |...:|      ....:.|..:|.:..|:
Mouse   324 -LFL--MCLIGAVGHSLWNGTFKEH-----------PPFDVPDADGNFLSLALGGFYMFLTMIIL 374

  Fly   521 LNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLT 585
            |..::|||||||:|:::..|.||::.|.::|...|:...:.|...:.|:||||||||||||||||
Mouse   375 LQVLIPISLYVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLT 439

  Fly   586 QNIMTFNKCSINGRSYGDVIDLRTGEL--------VEITEQQTI-----FQNSNTNNRPSPLSGA 637
            :|.|.|.:|:|.|..|....:.:..|:        .|.|:.|.:     :...:|..|..  .||
Mouse   440 ENKMVFRRCTIVGSEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWAQGSTTMRSQ--GGA 502

  Fly   638 IVAPPAAPPPIILVHKAEV----HAKKTS----------MVVTSSGEAQVLPDRP-RSDIERSAP 687
                    .|:...|.|.|    |.::.|          :..:||.|..|.||:. .|.:..:|.
Mouse   503 --------QPLRRCHSARVPIQSHCRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAAL 559

  Fly   688 PMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQR 752
            .::.|:.||       :.||.|..|........|.....:......|.|      ||.......:
Mouse   560 WLETSDTRP-------AKPSHSTTASIADFFLALTICNSVMVSTTTEPR------KRVTTPPANK 611

  Fly   753 QLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLD-EEP 816
            .|.  :|.:|::.|....:..:.:...||            .|||...||..:......:| :|.
Mouse   612 ALG--TSLEKIQQLFQRLKLLSLSQSFSS------------TAPSDTDLGESLGPNLPTIDSDEK 662

  Fly   817 QSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLL--DAVRSDE 879
            ..||..|.                            |.|.:..:.|. .|....:|  ::..|.|
Mouse   663 DDTSVCSG----------------------------DCSTDGGYRSS-TWEQGDILGSESGTSLE 698

  Fly   880 EHSHVFFRLLALCHTVMAETV---DGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV-M 940
            |             .:.|.|:   :.:|.|:|:||||||||.|||.:.|...:|||..:|:.: .
Mouse   699 E-------------GLEAPTLSQDEPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQ 750

  Fly   941 GQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDRLHGGQED----------- 992
            |....::||..|.|::|||||||::|.  .|.:::|.||||:||.|.|    ||
Mouse   751 GICLTFDLLFTLGFDSVRKRMSVVVRHPLTDEIIVYTKGADSVIMDLL----EDPACESNIDVEK 811

  Fly   993 ----LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIE 1053
                ::||||.||:.:|.:|||||.:|::.:.|:.:..|.|.::||..|:|:||:.|....:.:|
Mouse   812 KLKRIRARTQKHLDLYARDGLRTLCIAKKVVDEEDFQRWASFRREAEASLDNREELLMETAQHLE 876

  Fly  1054 SEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVD 1118
            :.:.|:|.|.|||:||:|||.:||.|:.|||::|||||||||||:||.|||:|| |:...|:.::
Mouse   877 NHLTLLGATGIEDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNIAYSCKLL-DQTDTVYSIN 940

  Fly  1119 GNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPP 1183
            ..:.|..|..|....|.||.::.                                         |
Mouse   941 TENQETCESILNCTLEDIKRFHE-----------------------------------------P 964

  Fly  1184 PPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVH 1248
            ..||..:...|...|......|..:.|                          ..||::|.:|..
Mouse   965 QQPARKLCGHRIPPKMPSVNSGAMAPE--------------------------IGLVIDGKTLNA 1003

  Fly  1249 CLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGV 1313
            ....:||||||::...|::|:|||.|||||:::|:|::...:.:||:|||||||||||:||.||:
Mouse  1004 IFQGKLENKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGI 1068

  Fly  1314 GISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCG 1378
            |||||||:|||:|||::||:|.:|::||||||.|.|.|:.:.:.|:||||..:.....||..|||
Mouse  1069 GISGQEGMQAVMSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCG 1133

  Fly  1379 FSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVL 1443
            ||..|:.|...:..:|||:||||.:..||.::|||.:..|..|.||..|..||.:|:..|..|:.
Mouse  1134 FSGSTMIDYWQMIFFNLFFTSLPPIIFGVLDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMA 1198

  Fly  1444 HGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTI 1508
            ...:.||:.|.|||..|:      |..: |..|.|..:.||.:.......::....|||::.:.:
Mouse  1199 DAFYQSLICFFIPYLTYR------GSDI-DVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVL 1256

  Fly  1509 WGSLVWYFVLDYFYNYVI------GGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLD 1567
            .||.:.|||:...||...      ..|| ..:.:.:.|.||::..|:|.:..:.|    :::||.
Mouse  1257 LGSFLMYFVVSLIYNATCVTCNSPTNPY-WVMERQLSDPTFYLICLLTPVVALLP----RYFLLS 1316

  Fly  1568 VHPSLSDKIRQKSLK--KIH-SRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHK 1629
            :..:....:..|:.|  |:. .:.:.:::...|.:|...:..|..|.|...|   .:.:....|.
Mouse  1317 LQGTYGKSLISKAQKIDKLPIDKRNLEIQNWRSKQRPAPASASASASAPATG---TVHTRPPCHP 1378

  Fly  1630 LPQDFAFPLGLGTKKT 1645
            :|.:.....|..|.|:
Mouse  1379 VPPEAQQNFGASTSKS 1394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	27/69 (39%)
		Cation_ATPase	891..985	CDD:289987	42/99 (42%)
		HAD_like	<1261..1324	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	86/252 (34%)
Atp10b	NP_795973.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..43		6/27 (22%)
		P-type_ATPase_APLT_Dnf-like	68..1211	CDD:319770	438/1317 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	638..707		21/122 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1348..1421		11/50 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1474
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830