DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp11c

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_006257661.1	Gene:	Atp11c / 317599	RGDID:	1564481	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	1426	Identity:	405/1426 - (28%)
Similarity:	650/1426 - (45%)	Gaps:	376/1426 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            ::.:|.|.:|||:|:.|||.||.|||:|:||||||.:.::| :...:..:|||:.:||..|:|:|
  Rat    40 RFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVT 103

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.:|::||......:.|.|.|..:..:::||||:.:..::....|.:|||:...
  Rat   104 AIKQGYEDWLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTT 168

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL-IWRGQ 401
            :|.|::.||.||||:|.|....:.:||||... :|:.|....|.||:|...|.||.|.: |:...
  Rat   169 DGTCYVTTASLDGESNCKTHYAVRDTIELCTA-ESIDNLRAAIECEQPQPDLYKFVGRISIYSNS 232

  Fly   402 RFA----LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN-SGKTQFKSTGVDRLLN-FIIIG 460
            ..|    |..|.:||:|..|:||:..|||.|:.|::||:..| .||:| |.:.|::.:| |:|:.
  Rat   233 IEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQ-KRSAVEKSINAFLIVY 296

  Fly   461 IVLFL--VSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNT 523
            :.:.|  .::|.....   :|:......    .||.:...:....|...:.....|.|:.::.|.
  Rat   297 LFILLTKAAVCTTLKY---VWQSTPYND----EPWYNQKTQKERETFKVLKMFTDFLSFMVLFNF 354

  Fly   524 VVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNI 588
            ::|:|:||:||:.:|:.||.|:||::.:....|..|...|:.|||||||:.|:|:|||||||:|.
  Rat   355 IIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENS 419

  Fly   589 MTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHK 653
            |.|.:|.|:|..|
  Rat   420 MEFIECCIDGHKY---------------------------------------------------- 432

  Fly   654 AEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLS 718
                          .|..|
  Rat   433 --------------KGTTQ---------------------------------------------- 437

  Fly   719 PRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHN 783
             .:||
  Rat   438 -EVDG------------------------------------------------------------ 441

  Fly   784 RKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHA 848
                                 :||::..|
  Rat   442 ---------------------LSQIDGPL------------------------------------ 449

  Fly   849 LQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAET---VDGKLE----- 905
                            .::|       ::|:....:|.|.|.|||||..:|   |||.:|
  Rat   450 ----------------AYFD-------KADKNREELFLRALCLCHTVEIKTNDAVDGPIEGAQFT 491

  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIE-VMGQTEEYELLNILDFNNVRKRMSVILR-RG 968
            |.:.||||.|||..|:.|||.|.......|.:| ...:.||||||:.|:|::||:|||||:| :|
  Rat   492 YISSSPDEIALVKGAQKFGFTFLGNWNGHIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQG 556

  Fly   969 DSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            ..::|:|||||:.|:.|:|..:.||   |:.|:.:.|.:|.|||.:|.:.:....:.....:..|
  Rat   557 GDILLFCKGADSSIFPRVHSHEIDL---TKVHVERNAMDGYRTLCVAFKEIPPDDFERINVQLIE 618

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |.:::..||:||..|::.||:.|.|:|.||:||||||...::|..|..||:|:|||||||.|||.
  Rat   619 AKMALQDREEKLEKIFDVIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAK 683

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            :..|:|:|.... .::..:...::||.|:     ||                |||:        .
  Rat   684 STCYACRLFQTN-TELLELTTKTIEESER-----KE----------------DRLH--------E 718

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTAS 1228
            :.:......:.|.        |.:...:...|.|..:              :|
  Rat   719 LLIEYRKKLLHEF--------PKSTRSLKKAWTEHQE--------------YG------------ 749

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNA-V 1292
            :::|.:| .:|::|  |...|.|...::.||.|..:|.||:|||:.|||||.:|.::|..|.: :
  Rat   750 LIIDGST-LSLILN--SSQDCSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPI 811

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            ||:|||||||||||..:|:|:||.|:||.||..:||||:.:|::|::|||.||...|.|:...::
  Rat   812 TLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQ 876

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            ||||||..|.|....|..|||||.|.::|..::::||:.:||||:||..:.||.::.......||
  Rat   877 YFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDALTADPR 941

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYK-DGVSANGFVVSDHMTLGAVVATILI 1486
            ||.....:.:..:..|:|.....||...|.|...|.::: ..:..||.:.. :.|.|.:|.|:|:
  Rat   942 LYMKITGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTTSLEDNGKIYG-NWTFGTIVFTVLV 1005

  Fly  1487 VDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQAMKDLTFWV 1545
            ...|.:::|.|.:||.:||..|||||.:|....:|:..:| .|::..      ..|.:..::.|:
  Rat  1006 FTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGII-WPFLKQQRMYFVFAQMLSSVSTWL 1069

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVR 1606
            .:::.:...:.|.:     ||         |..|::::..:|.:...||.:.|...|.|||
  Rat  1070 AIILLIFISLFPEI-----LL---------IVVKNVRRRSARRNLSCRRASDSLSARPSVR 1116

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/51 (45%)
		Cation_ATPase	891..985	CDD:289987	49/103 (48%)
		HAD_like	<1261..1324	CDD:304363	36/63 (57%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	78/253 (31%)
Atp11c	XP_006257661.1	PhoLip_ATPase_N	38..91	CDD:292826	23/51 (45%)
		ATPase-Plipid	41..1089	CDD:273734	396/1396 (28%)
		E1-E2_ATPase	98..>183	CDD:278548	30/84 (36%)
		Cation_ATPase	469..573	CDD:289987	49/103 (48%)
		HAD_like	<812..841	CDD:304363	20/28 (71%)
		PhoLip_ATPase_C	863..1090	CDD:292829	70/242 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720