Protein Alignment ATP8B and Atp11c

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_006257661.1
• Gene: Atp11c / 317599
• RGDID: 1564481
• Length: 1130
• Species: Rattus norvegicus
• Alignment Length: 1426
• Identity: 405/1426 - (28%)
• Similarity: 650/1426 - (45%)
• Gaps: 376/1426 - (26%)

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            ::.:|.|.:|||:|:.|||.||.|||:|:||||||.:.::| :...:..:|||:.:||..|:|:|
  Rat    40 RFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ-VTVDTPTSPVTSGLPLFFVITVT 103

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            |:|..|:|..||.:|::||......:.|.|.|..:..:::||||:.:..::....|.:|||:...
  Rat   104 AIKQGYEDWLRHRADNEVNKSTVYIIENAKRVRKESEKIKVGDVVEVQADETFPCDLILLSSCTT 168

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL-IWRGQ 401
            :|.|::.||.||||:|.|....:.:||||... :|:.|....|.||:|...|.||.|.: |:...
  Rat   169 DGTCYVTTASLDGESNCKTHYAVRDTIELCTA-ESIDNLRAAIECEQPQPDLYKFVGRISIYSNS 232

  Fly   402 RFA----LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN-SGKTQFKSTGVDRLLN-FIIIG 460
            ..|    |..|.:||:|..|:||:..|||.|:.|::||:..| .||:| |.:.|::.:| |:|:.
  Rat   233 IEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQ-KRSAVEKSINAFLIVY 296

  Fly   461 IVLFL--VSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNT 523
            :.:.|  .::|.....   :|:......    .||.:...:....|...:.....|.|:.::.|.
  Rat   297 LFILLTKAAVCTTLKY---VWQSTPYND----EPWYNQKTQKERETFKVLKMFTDFLSFMVLFNF 354

  Fly   524 VVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNI 588
            ::|:|:||:||:.:|:.||.|:||::.:....|..|...|:.|||||||:.|:|:|||||||:|.
  Rat   355 IIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENS 419

  Fly   589 MTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHK 653
            |.|.:|.|:|..|
  Rat   420 MEFIECCIDGHKY---------------------------------------------------- 432

  Fly   654 AEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLS 718
                          .|..|
  Rat   433 --------------KGTTQ---------------------------------------------- 437

  Fly   719 PRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHN 783
             .:||
  Rat   438 -EVDG------------------------------------------------------------ 441

  Fly   784 RKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHA 848
                                 :||::..|
  Rat   442 ---------------------LSQIDGPL------------------------------------ 449

  Fly   849 LQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAET---VDGKLE----- 905
                            .::|       ::|:....:|.|.|.|||||..:|   |||.:|
  Rat   450 ----------------AYFD-------KADKNREELFLRALCLCHTVEIKTNDAVDGPIEGAQFT 491

  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIE-VMGQTEEYELLNILDFNNVRKRMSVILR-RG 968
            |.:.||||.|||..|:.|||.|.......|.:| ...:.||||||:.|:|::||:|||||:| :|
  Rat   492 YISSSPDEIALVKGAQKFGFTFLGNWNGHIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQG 556

  Fly   969 DSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            ..::|:|||||:.|:.|:|..:.||   |:.|:.:.|.:|.|||.:|.:.:....:.....:..|
  Rat   557 GDILLFCKGADSSIFPRVHSHEIDL---TKVHVERNAMDGYRTLCVAFKEIPPDDFERINVQLIE 618

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |.:::..||:||..|::.||:.|.|:|.||:||||||...::|..|..||:|:|||||||.|||.
  Rat   619 AKMALQDREEKLEKIFDVIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAK 683

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            :..|:|:|.... .::..:...::||.|:     ||                |||:        .
  Rat   684 STCYACRLFQTN-TELLELTTKTIEESER-----KE----------------DRLH--------E 718

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTAS 1228
            :.:......:.|.        |.:...:...|.|..:              :|
  Rat   719 LLIEYRKKLLHEF--------PKSTRSLKKAWTEHQE--------------YG------------ 749

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNA-V 1292
            :::|.:| .:|::|  |...|.|...::.||.|..:|.||:|||:.|||||.:|.::|..|.: :
  Rat   750 LIIDGST-LSLILN--SSQDCSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPI 811

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            ||:|||||||||||..:|:|:||.|:||.||..:||||:.:|::|::|||.||...|.|:...::
  Rat   812 TLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQ 876

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            ||||||..|.|....|..|||||.|.::|..::::||:.:||||:||..:.||.::.......||
  Rat   877 YFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDALTADPR 941

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYK-DGVSANGFVVSDHMTLGAVVATILI 1486
            ||.....:.:..:..|:|.....||...|.|...|.::: ..:..||.:.. :.|.|.:|.|:|:
  Rat   942 LYMKITGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTTSLEDNGKIYG-NWTFGTIVFTVLV 1005

  Fly  1487 VDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LTQAMKDLTFWV 1545
            ...|.:::|.|.:||.:||..|||||.:|....:|:..:| .|::..      ..|.:..::.|:
  Rat  1006 FTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGII-WPFLKQQRMYFVFAQMLSSVSTWL 1069

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVR 1606
            .:::.:...:.|.:     ||         |..|::::..:|.:...||.:.|...|.|||
  Rat  1070 AIILLIFISLFPEI-----LL---------IVVKNVRRRSARRNLSCRRASDSLSARPSVR 1116

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	146/399 (37%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	210/581 (36%)
Atp11c	XP_006257661.1	P-type_ATPase_APLT_Dnf-like	43..975	CDD:319770	366/1264 (29%)
		PhoLip_ATPase_C	863..1090	CDD:465071	70/242 (29%)