DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp8b4

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_038962769.1	Gene:	Atp8b4 / 311396	RGDID:	1306712	Length:	1194	Species:	Rattus norvegicus

Alignment Length:	1451	Identity:	640/1451 - (44%)
Similarity:	845/1451 - (58%)	Gaps:	325/1451 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.||.::|||:::|.:|:|.:|.|.||||::.||||.||.|||||:||.|||.||:|||||.|||
  Rat    11 EVERVVKANDRDYNEKFQYADNRIHTSKYNILTFLPINLFEQFQRVANAYFLFLLILQLIPEISS 75

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            ||..||.:||:.|:::||||||.||..||.||:|||||:|:.|.|.||...||..|:|||:|:|:
  Rat    76 LTWFTTIVPLVLVISMTAVKDATDDFFRHKSDNQVNNRQSEVLINSKLQNEKWMNVKVGDIIKLE 140

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERP 385
            ||||||||.||||:|||:|||::||||||||||||.:|.|..|.|||....||..|:|.:|||.|
  Rat   141 NNQFVAADLLLLSSSEPHGLCYVETAELDGETNLKVRQALPVTSELGADISSLAKFDGIVICEAP 205

  Fly   386 NNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGV 450
            ||.|::|.|.|.|:..:..|.|:||:|||||||||.||:|:|:|||.|||||||||||:||.|.:
  Rat   206 NNKLDRFSGVLSWKDSKHTLSNQKIILRGCVLRNTSWCFGMVLFAGPDTKLMQNSGKTKFKRTSI 270

  Fly   451 DRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFF 515
            |||:|.:::.|..|||.:..:.|:|.:|||..:|..|:..|.|..      ....:...|.|.|:
  Rat   271 DRLMNTLVLWIFGFLVCLGIILAVGNSIWESEVGNQFRTSLFWRE------GEKSSLFSGFLTFW 329

  Fly   516 SYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDK 580
            ||.|:|||:|||||||||||||...|:.||||.:|||......|:|||||||||||||:||||||
  Rat   330 SYVIILNTLVPISLYVSVEVIRLGHSYFINWDRKMYYAAKAMPAEARTTTLNEELGQIEYIFSDK 394

  Fly   581 TGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            |||||||||||.|||||||.|       .||:::..:|
  Rat   395 TGTLTQNIMTFKKCSINGRVY-------AGEVLDDLDQ--------------------------- 425

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                   |.|:..||
  Rat   426 -------KKEITKKK-------------------------------------------------- 433

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775

  Rat   434 ----------------------------------------------------------------- 433

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840

  Rat   434 ----------------------------------------------------------------- 433

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVD-GKL 904
                     ::||||.....|....::|.:|::::...:...|.|.||||||||||:|... |:|
  Rat   434 ---------EAVDFSGKSKSERTLHFFDHSLMESIELGDPKVHEFLRLLALCHTVMSEEDSAGQL 489

  Fly   905 EYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            .||.|||||.|||:|||||||:|::|||.:||||.:|....|:||..|||||:|||||||:|..:
  Rat   490 VYQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTPVTYQLLAFLDFNNIRKRMSVIVRNPE 554

  Fly   970 SMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            ..: ||.||||.:::::||...|||.:.|.|||::||||||||||:|.|.|.::|:..|:...::
  Rat   555 GQIKLYSKGADTILFEKLHPSNEDLLSLTSDHLSEFAGEGLRTLAIAYRELDDKYFKMWQKMLED 619

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |..::..|:::::.:|||||.::.|:|.||:|||||:||.::|.:|..|.||||:||||||||||
  Rat   620 ANSAIAERDERISGLYEEIERDLMLLGATAVEDKLQEGVIETITSLSLANIKIWILTGDKQETAI 684

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            ||||:|.:|||.:..||::.||:..||.::||:.||::...|.....|...:
  Rat   685 NIGYACNVLTDAMDAVFVITGNTAVEVREELRKAKENLLGQNTSFSNGHAVY------------- 736

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTAS 1228
                                                 :||              ::...|.|...
  Rat   737 -------------------------------------ENK--------------QRLELDSGAGE 750

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVT 1293
            .|..|   :|||:|||||.|.|..::|...|::|..||.|:||||||||||.||||:|:.:||||
  Rat   751 TVTGE---YALVINGHSLAHALESDVEKDLLELACVCKTVVCCRVTPLQKAQVVELVKKHRNAVT 812

  Fly  1294 LAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRY 1358
            ||||||||||||||:||||:||||||||||||:|||::||||||:||||||||||||||||||.|
  Rat   813 LAIGDGANDVSMIKSAHIGIGISGQEGLQAVLASDYALAQFRYLQRLLLVHGRWSYYRMCKFLCY 877

  Fly  1359 FFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRL 1423
            ||||||||||.|.|::.:||||||||:|..||:::|:.||||||||:|||:||||::||::.|:|
  Rat   878 FFYKNFAFTLVHFWFAFYCGFSAQTVYDQWFITLFNIVYTSLPVLAMGVFDQDVSEQNSMDCPQL 942

  Fly  1424 YTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVD 1488
            |.||..:.|||.|.|...|.||.:|||:||.||||.:.:..:.:|..::|:.:....|||.|::.
  Rat   943 YEPGQLNLLFNKRRFFICVAHGIYTSLILFFIPYGAFYNVAAEDGQHIADYQSFAVTVATSLVIV 1007

  Fly  1489 NTAQISLYTSYWTVVNHVTIWGSLVWYF--VLDYFYNYVIG-----GPYVGSLTQAMKDLTFWVT 1546
            .:.||:|.||||||||||.||||:..||  :|....:.|.|     .|:||:..:::.....|:.
  Rat  1008 VSVQIALDTSYWTVVNHVFIWGSVATYFSILLAMHSDGVFGIFPRQFPFVGNARRSLSQKFVWLV 1072

  Fly  1547 MLITVMALVAPVLAYKFYLLDVHPSLSDKIR--QKSLKK---IHSRASSDVRRTASSRRGRRSVR 1606
            :|:|.:..|.||:.::|..:.::|||||:||  ||:.:|   :.||...  .|.:|||      |
  Rat  1073 VLLTAVTSVMPVVVFRFLKMHLYPSLSDQIRRWQKAQRKERPLRSRRPQ--TRRSSSR------R 1129

  Fly  1607 SGYAFAHQEGFGRLITSGKIM 1627
            ||||||||||:|.||||||.|
  Rat  1130 SGYAFAHQEGYGELITSGKNM 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	40/64 (63%)
		Cation_ATPase	891..985	CDD:289987	57/95 (60%)
		HAD_like	<1261..1324	CDD:304363	50/62 (81%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	131/253 (52%)
Atp8b4	XP_038962769.1	P-type_ATPase_APLT_Dnf-like	31..975	CDD:319770	554/1246 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5545
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820