Protein Alignment ATP8B and Atp10b

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001415672.1
• Gene: Atp10b / 303056
• RGDID: 1565126
• Length: 1472
• Species: Rattus norvegicus
• Alignment Length: 1499
• Identity: 474/1499 - (31%)
• Similarity: 744/1499 - (49%)
• Gaps: 272/1499 - (18%)

  Fly   166 SESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFK-----YHNNYIKTSKYSLFTFL 225
            |.|::.|    |......|.||..:| :|.:..|:...:..:|     |..|.|.|:||:|.|||
  Rat    23 SPSETTP----LLSPETGRQSYNPTE-QRVVYPNNSMCHQDWKKVSRRYPGNSICTTKYTLLTFL 82

  Fly   226 PFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQV 290
            |.||.|||.|.||.|||.|::|..:|::.......|.:||..||.:..|||..:|.:|:..|.::
  Rat    83 PQNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLLVIMVKDGTEDFKRYCFDREM 147

  Fly   291 NN-------RKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAEL 348
            |:       ||.::     .::.:|.:|:|||.:::..|:.|.||.|||.:|:|:|:|.:|||.|
  Rat   148 NSASIQIYERKEQS-----YMQKRWQDVRVGDFVQMRCNEIVPADILLLFSSDPSGVCHLETANL 207

  Fly   349 DGETNLKAKQCL----TETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFALDNE 408
            |||||||.::.:    .:.::....|     |:..|:||:|||.|:||.|.:....: |....:|
  Rat   208 DGETNLKQRRVVKGFSQQEVQFQPEH-----FHSTIVCEKPNNHLSKFKGYMEHPDETRTGFGSE 267

  Fly   409 KILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGIVLFLVSICA 470
            .:|||||.:|||:...|:|::||.:||.|.|:...::|.:.::|.:|   |..||: |||  :|.
  Rat   268 SLLLRGCTIRNTEVAAGIVIYAGHETKAMLNNSGPRYKRSKIERRINTDIFFCIGL-LFL--MCL 329

  Fly   471 LFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIP------TGATVIGLLVFFSYAIVLNTVVPISL 529
            :.|:|.::|.|...:|           |...:|      ....:.|..:|.:..|:|..::||||
  Rat   330 IGAVGHSLWNGTFKEH-----------PPFDVPDADGNFLSPALGGFYMFLTMIILLQVLIPISL 383

  Fly   530 YVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKC 594
            |||:|:::..|.||::.|.::|...|:...:.|...:.|:||||||||||||||||:|.|.|.:|
  Rat   384 YVSIELVKLGQVFLLHNDLDLYDEETDLSIQCRALNITEDLGQIQYIFSDKTGTLTENKMVFRRC 448

  Fly   595 SINGRSYGDVIDLRTGEL--------VEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILV 651
            :|.|..|....:.:..|:        .|.|:.|.:.........|     |.:.......|:...
  Rat   449 TIVGNEYCHQENAKRLEMPKELDSDGEEWTQYQCLSFPPRWTQGP-----ATIRSQGGAQPLRRC 508

  Fly   652 HKAEV----HAKKTS----------MVVTSSGEAQVLPDRP-RSDIERSAPPMDASEKRPGLKHV 701
            |.|.|    |:::.|          :..:||.|..|.||:. .|.:..:|..::..:.||
  Rat   509 HSARVPIQSHSRQRSVGRWETSQPPVAFSSSIEKDVTPDKNLLSKVRDAALWLETLDTRP----- 568

  Fly   702 RYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKIL 766
              :.||.|..|........|                                    :.|:.|.:
  Rat   569 --AKPSHSTTASIADFFLAL------------------------------------TICNSVMV- 594

  Fly   767 HDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEH---HLDEEPQSTSTLSTTKHH 828
              |..||.         |||:.     ..|:...||..:.:::|   .|.....|.|..||....
  Rat   595 --STTTEP---------RKRVT-----TPPANKALGTSLEKIQHLFQRLKLLSLSQSFSSTAPSD 643

  Fly   829 HHRSKAFATNWSSSPHRVHALQSVDFSA--------NPHHESDFRWYDRTLLDAVRSDEEHSHVF 885
            ....::...|..:    :.|.:..|.|.        ..:..|.:...|....::..|.||...
  Rat   644 TDLGESLGPNVPT----IDADEKDDASVCSGDCSTDGGYRSSTWEQGDNLGSESGTSLEEGLE-- 702

  Fly   886 FRLLALCHTVMAETVDG-KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYEL 948
                     ..|.::|| :|.|:|:||||||||.|||.:.|...:|||..:|:.: .|....::|
  Rat   703 ---------APALSLDGPELCYEAESPDEAALVHAARAYSFTLVSRTPEQVTVRLPQGICLTFDL 758

  Fly   949 LNILDFNNVRKRMSVILRR---GDSMVLYCKGADNVIYDRLH----GGQED-------LKARTQD 999
            |..|.|::|||||||::|.   |: :|:|.||||:||.|.|.    |...|       ::||||.
  Rat   759 LFTLGFDSVRKRMSVVVRHPLTGE-IVVYTKGADSVIMDLLEDPACGNDIDVEKKLKRIRARTQK 822

  Fly  1000 HLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAI 1064
            ||:.:|.:|||||.:|::.:.|:.:..|.|.::||..|:|:||:.|....:.:|:.:.|:|.|.|
  Rat   823 HLDLYARDGLRTLCIAKKVVNEEDFQRWASFRREAEASLDNREELLMETAQHLENRLTLLGATGI 887

  Fly  1065 EDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQL 1129
            ||:||:|||.:||.|:.|||::|||||||||||:|:.:||:|| |:...|:.::..:.|..|..|
  Rat   888 EDRLQEGVPDTIAALREAGIQLWVLTGDKQETAVNVAHSCKLL-DQADTVYSINTENQETCESIL 951

  Fly  1130 RQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFR 1194
            ....|.:|.::.                                         |..||..:
  Rat   952 NCALEDVKRFHE-----------------------------------------PQQPARKL---- 971

  Fly  1195 WDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFL 1259
                            |......:|.|.:.|..:..:      .||::|.:|......:||||||
  Rat   972 ----------------CGYCIPSKKPSVNLGAMAPEI------GLVIDGKTLNAIFQGKLENKFL 1014

  Fly  1260 DIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAV 1324
            ::...|::|:|||.|||||:::|:|::...:.:||:|||||||||||:||.||:|||||||:|||
  Rat  1015 ELTQYCRSVLCCRSTPLQKSMIVKLVRDKLSVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAV 1079

  Fly  1325 LSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMF 1389
            :|||::||:|.:|::||||||.|.|.|:.:.:.|:||||..:.....||..|||||..|:.|...
  Rat  1080 MSSDFAIARFSHLKKLLLVHGHWCYSRLARMVVYYFYKNVCYVNLLFWYQFFCGFSGSTMIDYWQ 1144

  Fly  1390 ISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFL 1454
            :..:|||:||||.:..|:.::|||.:..|..|.||..|..||.:|:..|..|:....:.||:.|.
  Rat  1145 MIFFNLFFTSLPPIVFGILDKDVSAETLLALPELYKSGQNSECYNLPTFWVSMADAFYQSLICFF 1209

  Fly  1455 IPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLD 1519
            |||..|:      |..: |..|.|..:.||.:.......::....|||::.:.:.||.:.|||:.
  Rat  1210 IPYLTYR------GSDI-DVFTFGTPINTISLTTILLHQAMEMKTWTVLHGLVLLGSFLMYFVVS 1267

  Fly  1520 YFYNYVI------GGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQ 1578
            ..||...      ..|| ..:.:.:.|..|::|.|:|.:..:.|    :::||.:..:....:..
  Rat  1268 LIYNATCVTCNSPTNPY-WLMERQLSDPMFYLTCLLTPVVALLP----RYFLLSLQGTYGKSLIS 1327

  Fly  1579 KSLK 1582
            |:.|
  Rat  1328 KAQK 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	154/411 (37%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	222/586 (38%)
Atp10b	NP_001415672.1	None