Protein Alignment ATP8B and Atp8b3

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_234937.3
• Gene: Atp8b3 / 299616
• RGDID: 1307622
• Length: 1340
• Species: Rattus norvegicus
• Alignment Length: 1587
• Identity: 519/1587 - (32%)
• Similarity: 768/1587 - (48%)
• Gaps: 403/1587 - (25%)

  Fly   196 IRANDKEFNAQF-----------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQL 249
            ::|||:.::.||           ||.:|.|.|:||::|:|||.||.|||:|::|.|||.:::||.
  Rat    21 VKANDRAYHKQFRKKGFLCWRQKKYKSNAIHTAKYNVFSFLPLNLYEQFRRVSNLYFLFIIILQS 85

  Fly   250 IPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVG 314
            ||.||:|...|...||:.:|.:.|.:|..|||.||.||..:|||..:.|:....:..||..:.||
  Rat    86 IPEISTLPWFTLFAPLVCLLMIRAARDLVDDIGRHRSDRIINNRPCQILKGKSFLWKKWKNLCVG 150

  Fly   315 DVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHD-----SLW 374
            ||:.|..:..|.||.|||:::||:.||::|||::|||||||.:|.|..|     .|:     .:.
  Rat   151 DVVCLSKDNIVPADLLLLASTEPSSLCYLETADIDGETNLKFRQALMVT-----HHELTSPKKMA 210

  Fly   375 NFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQN 439
            :|.|.:.||.||:.::.|.|:|.|..:::.||...:|||||.:|||..|||:|::||:|||:|:|
  Rat   211 SFQGIVTCEEPNSRMHHFVGSLEWNSRKYPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKN 275

  Fly   440 SGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCA--IWEGLIGQHFQLYLPWEHIIPKDYI 502
            .||...|.|.:|.::|.::|.|.:.||.......:|.|  :.|.....|:...:
  Rat   276 CGKIHLKRTKLDLMMNKLVILIFMSLVIASMFLTLGFAFMVKEFKAKHHYMSSM----------- 329

  Fly   503 PTGAT--VIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTT 565
             .|.|  :....:|:.:.|:|:.:||:::::..|.|....|..||||..|||...:..||||:|:
  Rat   330 -QGRTDAMDSFFIFWGFLILLSVMVPMAMFIIAEFIYLGNSIFINWDLSMYYEPLDIPAKARSTS 393

  Fly   566 LNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNR 630
            ||:.|||:||||||||||||||||||.||.|||.:|
  Rat   394 LNDHLGQVQYIFSDKTGTLTQNIMTFKKCCINGCTY----------------------------- 429

  Fly   631 PSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKR 695
                                                                             
  Rat   430 ----------------------------------------------------------------- 429

  Fly   696 PGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSC 760
                           |:|        |..|.|
  Rat   430 ---------------DSD--------DEHGTL--------------------------------- 438

  Fly   761 DKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTT 825
                                   |||
  Rat   439 -----------------------RKR--------------------------------------- 441

  Fly   826 KHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHS-HVFFRLL 889
                            :|          :|.||..:...::|::.|...||..::.: ..|:|||
  Rat   442 ----------------NP----------YSWNPFADGKLQFYNKELESLVRGKQDRAVQEFWRLL 480

  Fly   890 ALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDF 954
            |:|||||.:..|.:|.|||.||||.|||:||||||:||.:||.::||:..:|:...|::|.::||
  Rat   481 AICHTVMVQEKDNQLLYQAASPDEEALVAAARNFGYVFLSRTQDTITLVELGEERVYQVLAMMDF 545

  Fly   955 NNVRKRMSVILRRGD-SMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERR 1018
            |:|||||||::|..: |:.||.||||.||.:||| .:..::|.|::.|..||.:.||||.||.:.
  Rat   546 NSVRKRMSVLVRNPEGSICLYTKGADTVILERLH-HKGVMEATTEEVLAAFAEQTLRTLCLAYKD 609

  Fly  1019 LTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAG 1083
            :.|..|.:|....|||||.:.:|.|.|:.:|.::|..:||:||||||||||||||::|..|:...
  Rat   610 VAEDAYKEWEPEHQEAALLLQNRAQALHQVYNKLEQNLQLLGVTAIEDKLQDGVPETIRCLKKGN 674

  Fly  1084 IKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFD 1148
            ||:|||||||.|||:|||::||||::.:         |:.| :|.::...|:.          :|
  Rat   675 IKMWVLTGDKPETAVNIGFACQLLSENM---------SILE-DKDIKGLLENY----------WD 719

  Fly  1149 PFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNN 1213
            ..:...:...|...::.:.....|:.:..|.....|                       .|...|
  Rat   720 ENEHQRAFQTMTHHNMALVINGEFLDQLLLSLRKEP-----------------------RALVQN 761

  Fly  1214 LFGDEKGSEDGGTASIVVD--------ENTGFALVVNGHSLVHCL-SPE--LENKFLDIASQCKA 1267
            ...||...|.|.:|...:.        .|.|..:..:........ |||  .|..|:|:||:|:|
  Rat   762 AVVDEATQEPGVSALDFLQARRISQMWRNFGTTMATSQSDASKTRESPEERRERAFVDLASKCQA 826

  Fly  1268 VICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIA 1332
            ||||||||.||||||.|:|:.:..||||||||||||:|||.|.||||::||||:|||.:|||.:|
  Rat   827 VICCRVTPKQKALVVALVKKYQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLA 891

  Fly  1333 QFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFY 1397
            ||.||:|||||||||||.|:||||||||||..|..:...|:|||.|||||.:::..|::::||.|
  Rat   892 QFCYLQRLLLVHGRWSYMRICKFLRYFFYKTVASMMAQIWFSLFNGFSAQPLYEGWFLALFNLLY 956

  Fly  1398 TSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLF----LIPYG 1458
            ::||||.:|:|||||:.:.||:.|.|||.|.|.||||...|:.::.||..|||:.|    |:.|.
  Rat   957 STLPVLYIGLFEQDVTAEKSLKMPELYTAGQKDELFNYSIFVQAIAHGTITSLINFFVTILVSYD 1021

  Fly  1459 VYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYN 1523
            :.|.|.|      .|:.:.|.:||...::..|.::.|...|||::...|:..||..|.:......
  Rat  1022 MTKTGSS------PDYQSFGVLVAISSLLSITLEVILVVKYWTLLFVGTVVVSLSSYVIFTSLTE 1080

  Fly  1524 YVI-------GGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFY---LLDVHPSLSDKIRQ 1578
            .::       ..|::.:....:::.:..:.:::.|.....|:||.:..   :|..||...:::..
  Rat  1081 SLLLFRISPKTFPFLFADYNVIREPSSLLVIVLNVTLNTLPMLAVRIIRRTVLKRHPKKEEEVPS 1145

  Fly  1579 KSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTK 1643
            :.|         .|......|||..:.||.|||:|.||:..|||.|.|:.:
  Rat  1146 EEL---------TVEPAMRLRRGMPARRSSYAFSHHEGYANLITQGTILRR-------------- 1187

  Fly  1644 KTQVLHNNLN------SADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSSMADITADGRGNGGDD 1702
                 |.:::      :.:.||....:|.          .:|.::..:.....|.|..|..  ..
  Rat  1188 -----HTHVDEFYGDTACNSPNPSEEDVP----------WQHKESIFNPRKISILAKKRRQ--HY 1235

  Fly  1703 GRGSGGSDDMSPRAPCQDLD---TINL 1726
            |:||.|  ::.|.|..|..:   .||:
  Rat  1236 GKGSQG--EVHPNASSQTTEKQTAINI 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	33/74 (45%)
		Cation_ATPase	891..985	CDD:289987	52/94 (55%)
		HAD_like	<1261..1324	CDD:304363	45/62 (73%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	99/260 (38%)
Atp8b3	XP_234937.3	PhoLip_ATPase_N	20..96	CDD:292826	33/74 (45%)
		ATPase-Plipid	45..1143	CDD:273734	478/1402 (34%)
		Cation_ATPase	483..577	CDD:289987	52/93 (56%)
		COG4087	<839..890	CDD:226572	35/50 (70%)
		PhoLip_ATPase_C	883..1131	CDD:292829	97/253 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I5545
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830