DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp8b1

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_001099610.1	Gene:	Atp8b1 / 291555	RGDID:	1308488	Length:	1259	Species:	Rattus norvegicus

Alignment Length:	1526	Identity:	607/1526 - (39%)
Similarity:	815/1526 - (53%)	Gaps:	360/1526 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 SDDQ---ELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEF-------NA 205
            |||:   || :.:.|:|.      |...|:::...::...:..:...:::|||::|       |.
  Rat    25 SDDETEDEL-EDQGPAVE------PEQNRVNREVEKKKETFRKDCTWQVKANDRKFHEQPHFMNT 82

  Fly   206 QF------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIP 264
            :|      ||.:|.|||.||:..||||.||.|||:|.||||||.||:||.||.||:|...||.:|
  Rat    83 KFFCIKESKYASNAIKTYKYNALTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVP 147

  Fly   265 LIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADT 329
            |:.||.:||:||..||:.||..|.::|||..:.:::|:....||.::||||||||..|.|:.||.
  Rat   148 LLLVLGITAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADI 212

  Fly   330 LLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDG 394
            ||||:||||.||::||||||||||||.|..|..|.:.....|:|..|:|.|.||.|||.|:||.|
  Rat   213 LLLSSSEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTG 277

  Fly   395 TLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIII 459
            ||.||.|.|.||.:||||||||:|||..|:|:|:|||.|||:|:|||||:||.|.:|.|:|:::.
  Rat   278 TLFWRNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVY 342

  Fly   460 GIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTV 524
            .|::.|:.:.|..|||.|.||..||.:.......|:..|        :..|.|.|:.|.|||||:
  Rat   343 TIIIVLILVSAGLAIGHAYWEAQIGNYSWYLYDGENATP--------SYRGFLNFWGYIIVLNTM 399

  Fly   525 VPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIM 589
            |||||||||||||..||..||||.:|||...:|.||:|||||||:||||.|||||||||||||||
  Rat   400 VPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKSRTTTLNEQLGQIHYIFSDKTGTLTQNIM 464

  Fly   590 TFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKA 654
            ||.||.|||..|||                                                |:
  Rat   465 TFKKCCINGTIYGD------------------------------------------------HR- 480

  Fly   655 EVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSP 719
                                               |||:
  Rat   481 -----------------------------------DASQ-------------------------- 484

  Fly   720 RLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNR 784

  Rat   485 ----------------------------------------------------------------- 484

  Fly   785 KRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHAL 849
                                                        |..||               :
  Rat   485 --------------------------------------------HSHSK---------------I 490

  Fly   850 QSVDFSANPHHESDFRWYDRTLLDAVRSDEE-HSHVFFRLLALCHTVMAETVDGKLEYQAQSPDE 913
            :.||||.|...:....:||..|::.::|.:| ....||.||::|||||.:.:||::.|||.||||
  Rat   491 ELVDFSWNEFADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLSICHTVMVDRIDGQINYQAASPDE 555

  Fly   914 AALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD-SMVLYCKG 977
            .|||:|||||||.|..||.|:||:..:|....|.:|.|||||:.|||||:|:|..: |:.|||||
  Rat   556 GALVNAARNFGFAFLARTQNTITVSELGTERTYSVLAILDFNSDRKRMSIIVRTPEGSIRLYCKG 620

  Fly   978 ADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSRE 1042
            ||.|||:||| ....:|..|||.|:.||.|.||||.|..:.:.|:.:.:|..:...|:::..:|:
  Rat   621 ADTVIYERLH-RMNPMKQETQDALDIFASETLRTLCLCYKEIEEKEFAEWNKKFMAASVASSNRD 684

  Fly  1043 QKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLL 1107
            :.|:.:|||||.::.|:|.||||||||||||::|:.|..|.||||||||||:|||.|||::|:||
  Rat   685 EALDKVYEEIERDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELL 749

  Fly  1108 TDELADVFIVDGNSV--EEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTS 1170
            |::....:..|.||:  ..:|.|..:...|.|    |.|..::||
  Rat   750 TEDTTICYGEDINSLLHTRMENQRNRGGVSAK----FAPPAYEPF-------------------- 790

  Fly  1171 AFMQETNLPPTPPPPPAISVVTFRW------DEKNKDNK----GGPDSAECNNLFGDEKGSEDGG 1225
                      .||......::|..|      ::|.|.:|    ..|.:.|...:....:..
  Rat   791 ----------FPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRR---- 841

  Fly  1226 TASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKN 1290
                 ::|.                ..:.:..|:|:|.:|.|||||||||.|||:||:|:||.|.
  Rat   842 -----LEEK----------------KEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKK 885

  Fly  1291 AVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKF 1355
            |:|||||||||||:|||.||||||||||||:|||:|||||.||||||:|||||||||||.|||||
  Rat   886 AITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKF 950

  Fly  1356 LRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEF 1420
            |||||||||||||.|.|||.|.|:||||.::..||::||:.|:|||||.:|:.:||||||.||.|
  Rat   951 LRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRF 1015

  Fly  1421 PRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATIL 1485
            |.||..|.:..|||.::|..|:|||..||:|||.||:|.|...|..:|...||:.:....:|:.|
  Rat  1016 PGLYVVGQRDLLFNYKKFFVSLLHGVLTSMVLFFIPFGAYLQTVGQDGEAPSDYQSFAVTMASAL 1080

  Fly  1486 IVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYV-----------------GS 1533
            ::....||.|.|||||.||..:|:||:..||.:  .:::...|.:|                 .:
  Rat  1081 VITVNFQIGLDTSYWTFVNAFSIFGSIALYFGI--MFDFHSAGIHVLFPSAFQFTGWCFSDSEST 1143

  Fly  1534 LTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASS 1598
            .:.|::....|:|:::||...:.||:|.:|..:.:.||.|||| ||..|::.:..... ||.:..
  Rat  1144 ASNALRQPYIWLTIILTVAVCLLPVVAIRFLSMTIWPSESDKI-QKHRKRLKAEEQWK-RRQSVF 1206

  Fly  1599 RRGRRSVRSGYAFAHQEGFGRLITSGKIMHK 1629
            |||..|.||.|||:||.|:..||:||:.:.|
  Rat  1207 RRGASSRRSAYAFSHQRGYADLISSGRSIRK 1237

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	39/77 (51%)
		Cation_ATPase	891..985	CDD:289987	56/94 (60%)
		HAD_like	<1261..1324	CDD:304363	48/62 (77%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	124/263 (47%)
Atp8b1	NP_001099610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		9/33 (27%)
		PhoLip_ATPase_N	86..142	CDD:292826	33/55 (60%)
		ATPase-Plipid	92..1187	CDD:273734	569/1399 (41%)
		E1-E2_ATPase	171..>234	CDD:278548	34/62 (55%)
		Cation_ATPase	534..628	CDD:289987	56/93 (60%)
		HAD_like	<875..919	CDD:304363	34/43 (79%)
		PhoLip_ATPase_C	919..1181	CDD:292829	124/263 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	267	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.790