DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp9b

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_017456363.1	Gene:	Atp9b / 291411	RGDID:	1563006	Length:	1158	Species:	Rattus norvegicus

Alignment Length:	1557	Identity:	384/1557 - (24%)
Similarity:	592/1557 - (38%)	Gaps:	527/1557 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 SFYSL---APGGGNPPPNKSDDQELYKQRDPSVTSE------SKSVPSLRRLSQIRRRRSSYYF- 189
            ::||.   .||.......:.:|:..:....|.:.||      .....:|.|....||.|...:|
  Rat    24 AYYSAVGPGPGADRRGRYQLEDESAHLDEMPLMMSEEGFENDESDYHTLPRARITRRERGLEWFV 88

  Fly   190 ------------------SENERRIRAN-------DKEFNAQFKYHNNYIKTSKYSLFTFLPFNL 229
                              .:.::.::|.       :|   .:.|:..|.||..||::|||:|..|
  Rat    89 CGGWKFLCTSCCDWLINVCQRKKELKARTVWLGCPEK---CEEKHPRNSIKNQKYNVFTFIPGVL 150

  Fly   230 LEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNR- 293
            .|||:...|.|||.:...|.:||:......|...||..|:.:|..::|.|:.:|...|.::|::
  Rat   151 YEQFKFFLNLYFLVVSCSQFVPALKIGYLYTYWAPLGFVMAVTIAREAIDEFRRFQRDKEMNSQL 215

  Fly   294 KSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAK- 357
            .||....|| |:.|.|::||||:|.::.||.:.:|.:.|.|||..|.|||.|.:|||||:.|.|
  Rat   216 YSKLTVRGK-VQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKV 279

  Fly   358 --QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNT 420
              .|......|||    |::.:..:..::|...::.|:||..      ..|::..:.....:.||
  Rat   280 AVSCTQRLPALGD----LFSISAYVYAQKPQLDIHSFEGTFT------RDDSDPPIHESLSIENT 334

  Fly   421 QWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGC 476
            .|.         .|||::.|.:|:.:.|:...:.|...:|..||.:...:.|.||    :.::..
  Rat   335 LWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALV----VLSVVM 395

  Fly   477 AIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQS 541
            ...:|..|       ||..           .:...|:.|||      ::||||.|::::.:....
  Rat   396 VTLQGFAG-------PWYR-----------NLFRFLLLFSY------IIPISLRVNLDMGKAAYG 436

  Fly   542 FLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKT-----------GTLTQNIMTFNKCS 595
            ::|..||.:  |.|    ..||:|:.||||::.|:.:|||           .|||||.|.|.:..
  Rat   437 WMIMKDENI--PGT----VVRTSTIPEELGRLVYLLTDKTVTKAKALYSPARTLTQNEMVFKRLH 495

  Fly   596 INGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAK 659
            :...||| |.:|          |.|:...||                           ..:||:
  Rat   496 LGTVSYGTDTMD----------EIQSHVLNS---------------------------YLQVHS- 522

  Fly   660 KTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGS 724

  Rat   523 ----------------------------------------------------------------- 522

  Fly   725 GGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVK 789
                                                          ||..||
  Rat   523 ----------------------------------------------QTSGHN------------- 528

  Fly   790 IRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDF 854
                  ||:|                |...|..||.|..           .|...|:|
  Rat   529 ------PSSA----------------PLRRSQSSTPKVK-----------KSVSSRIH------- 553

  Fly   855 SANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVM----AET-VDGKLE--------- 905
                              :||::           :||||.|.    |.| :.|:.|
  Rat   554 ------------------EAVKA-----------IALCHNVTPVYEARTGITGETEFAEADQDFS 589

  Fly   906 -----YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYELLNILDFNNVRKRMSVI 964
                 |||.||||.|||....:.|....:|...|:.::. .||...|.:|.:..|.:..|||.:|
  Rat   590 DENRTYQASSPDEVALVRWTESVGLTLVSRDLASMQLKTPSGQVLTYCILQMFPFTSESKRMGII 654

  Fly   965 LR--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDW 1027
            :|  ....:..|.|||| |....:....:.|    ::.....|.||||||.:|:|.|||:.|.|:
  Rat   655 VRDEATAEITFYMKGAD-VAMSTIVQYNDWL----EEECGNMAREGLRTLVVAKRTLTEEQYQDF 714

  Fly  1028 RSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGD 1092
            .||..:|.||:..|..|:.|:.|.:|.||:|:.:|.:||:||..|..::..|:|||||||:||||
  Rat   715 ESRYSQAKLSIHDRTLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGD 779

  Fly  1093 KQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDS 1157
            |.|||..|..|..|:: ...|:.|                         |||
  Rat   780 KLETATCIAKSSHLVS-RTQDIHI-------------------------FRP------------- 805

  Fly  1158 NMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSE 1222
                    :|.......|.|              .||  .|:          :|
  Rat   806 --------VTNRGEAHLELN--------------AFR--RKH----------DC----------- 825

  Fly  1223 DGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKR 1287
                           |||::|.||..||. ..|::.:::|.||.||:|||.:|.|||.:|.|:::
  Rat   826 ---------------ALVISGDSLEVCLR-YYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQ 874

  Fly  1288 AKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            .....|.|||||.||||||:||..|:||.|:||.||.|::|:||.|||::.|||:||||.||.|.
  Rat   875 HTRKRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRS 939

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ....::..::....:.....:|....|::..::....:..|...||..||.:| |.:|||..:.:
  Rat   940 AALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMA 1003

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVV---SDHMTLGA 1479
            :.:|.||....|....:.:.|:..||             ..:|:.|:...|.::   ::.:.:.|
  Rat  1004 ILYPELYKDLTKGRSLSFKTFLIWVL-------------ISIYQGGILMYGALLLFEAEFVHVVA 1055

  Fly  1480 VVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLT--------- 1535
            :..|.||:.....::|....|    |        |..|:..|.:.   |.||.||.
  Rat  1056 ISFTALILTELLMVALTIRTW----H--------WLMVVAEFLSL---GCYVASLAFLNEYFGIG 1105

  Fly  1536 ----QAMKDLTF-------WVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHS 1586
                .|..|:.|       |....|||::.: |:...|:        |..|:...|..|:.|
  Rat  1106 RVSFGAFLDVAFITTVTFLWKVSAITVVSCL-PLYVLKY--------LKRKLSPPSYSKLSS 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/71 (32%)
		Cation_ATPase	891..985	CDD:289987	37/115 (32%)
		HAD_like	<1261..1324	CDD:304363	35/62 (56%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	63/269 (23%)
Atp9b	XP_017456363.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.020