Protein Alignment ATP8B and Atp9b

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_017456363.1
• Gene: Atp9b / 291411
• RGDID: 1563006
• Length: 1158
• Species: Rattus norvegicus
• Alignment Length: 1557
• Identity: 384/1557 - (24%)
• Similarity: 592/1557 - (38%)
• Gaps: 527/1557 - (33%)

  Fly   135 SFYSL---APGGGNPPPNKSDDQELYKQRDPSVTSE------SKSVPSLRRLSQIRRRRSSYYF- 189
            ::||.   .||.......:.:|:..:....|.:.||      .....:|.|....||.|...:|
  Rat    24 AYYSAVGPGPGADRRGRYQLEDESAHLDEMPLMMSEEGFENDESDYHTLPRARITRRERGLEWFV 88

  Fly   190 ------------------SENERRIRAN-------DKEFNAQFKYHNNYIKTSKYSLFTFLPFNL 229
                              .:.::.::|.       :|   .:.|:..|.||..||::|||:|..|
  Rat    89 CGGWKFLCTSCCDWLINVCQRKKELKARTVWLGCPEK---CEEKHPRNSIKNQKYNVFTFIPGVL 150

  Fly   230 LEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNR- 293
            .|||:...|.|||.:...|.:||:......|...||..|:.:|..::|.|:.:|...|.::|::
  Rat   151 YEQFKFFLNLYFLVVSCSQFVPALKIGYLYTYWAPLGFVMAVTIAREAIDEFRRFQRDKEMNSQL 215

  Fly   294 KSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAK- 357
            .||....|| |:.|.|::||||:|.::.||.:.:|.:.|.|||..|.|||.|.:|||||:.|.|
  Rat   216 YSKLTVRGK-VQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKLKV 279

  Fly   358 --QCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNT 420
              .|......|||    |::.:..:..::|...::.|:||..      ..|::..:.....:.||
  Rat   280 AVSCTQRLPALGD----LFSISAYVYAQKPQLDIHSFEGTFT------RDDSDPPIHESLSIENT 334

  Fly   421 QWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGC 476
            .|.         .|||::.|.:|:.:.|:...:.|...:|..||.:...:.|.||    :.::..
  Rat   335 LWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALV----VLSVVM 395

  Fly   477 AIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQS 541
            ...:|..|       ||..           .:...|:.|||      ::||||.|::::.:....
  Rat   396 VTLQGFAG-------PWYR-----------NLFRFLLLFSY------IIPISLRVNLDMGKAAYG 436

  Fly   542 FLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKT-----------GTLTQNIMTFNKCS 595
            ::|..||.:  |.|    ..||:|:.||||::.|:.:|||           .|||||.|.|.:..
  Rat   437 WMIMKDENI--PGT----VVRTSTIPEELGRLVYLLTDKTVTKAKALYSPARTLTQNEMVFKRLH 495

  Fly   596 INGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAK 659
            :...||| |.:|          |.|:...||                           ..:||:
  Rat   496 LGTVSYGTDTMD----------EIQSHVLNS---------------------------YLQVHS- 522

  Fly   660 KTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGS 724
                                                                             
  Rat   523 ----------------------------------------------------------------- 522

  Fly   725 GGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVK 789
                                                          ||..||
  Rat   523 ----------------------------------------------QTSGHN------------- 528

  Fly   790 IRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDF 854
                  ||:|                |...|..||.|..           .|...|:|
  Rat   529 ------PSSA----------------PLRRSQSSTPKVK-----------KSVSSRIH------- 553

  Fly   855 SANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVM----AET-VDGKLE--------- 905
                              :||::           :||||.|.    |.| :.|:.|
  Rat   554 ------------------EAVKA-----------IALCHNVTPVYEARTGITGETEFAEADQDFS 589

  Fly   906 -----YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYELLNILDFNNVRKRMSVI 964
                 |||.||||.|||....:.|....:|...|:.::. .||...|.:|.:..|.:..|||.:|
  Rat   590 DENRTYQASSPDEVALVRWTESVGLTLVSRDLASMQLKTPSGQVLTYCILQMFPFTSESKRMGII 654

  Fly   965 LR--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDW 1027
            :|  ....:..|.|||| |....:....:.|    ::.....|.||||||.:|:|.|||:.|.|:
  Rat   655 VRDEATAEITFYMKGAD-VAMSTIVQYNDWL----EEECGNMAREGLRTLVVAKRTLTEEQYQDF 714

  Fly  1028 RSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGD 1092
            .||..:|.||:..|..|:.|:.|.:|.||:|:.:|.:||:||..|..::..|:|||||||:||||
  Rat   715 ESRYSQAKLSIHDRTLKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNAGIKIWMLTGD 779

  Fly  1093 KQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDS 1157
            |.|||..|..|..|:: ...|:.|                         |||
  Rat   780 KLETATCIAKSSHLVS-RTQDIHI-------------------------FRP------------- 805

  Fly  1158 NMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSE 1222
                    :|.......|.|              .||  .|:          :|
  Rat   806 --------VTNRGEAHLELN--------------AFR--RKH----------DC----------- 825

  Fly  1223 DGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKR 1287
                           |||::|.||..||. ..|::.:::|.||.||:|||.:|.|||.:|.|:::
  Rat   826 ---------------ALVISGDSLEVCLR-YYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQ 874

  Fly  1288 AKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRM 1352
            .....|.|||||.||||||:||..|:||.|:||.||.|::|:||.|||::.|||:||||.||.|.
  Rat   875 HTRKRTCAIGDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRS 939

  Fly  1353 CKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNS 1417
            ....::..::....:.....:|....|::..::....:..|...||..||.:| |.:|||..:.:
  Rat   940 AALGQFVMHRGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSL-VLDQDVKPEMA 1003

  Fly  1418 LEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVV---SDHMTLGA 1479
            :.:|.||....|....:.:.|:..||             ..:|:.|:...|.::   ::.:.:.|
  Rat  1004 ILYPELYKDLTKGRSLSFKTFLIWVL-------------ISIYQGGILMYGALLLFEAEFVHVVA 1055

  Fly  1480 VVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLT--------- 1535
            :..|.||:.....::|....|    |        |..|:..|.:.   |.||.||.
  Rat  1056 ISFTALILTELLMVALTIRTW----H--------WLMVVAEFLSL---GCYVASLAFLNEYFGIG 1105

  Fly  1536 ----QAMKDLTF-------WVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHS 1586
                .|..|:.|       |....|||::.: |:...|:        |..|:...|..|:.|
  Rat  1106 RVSFGAFLDVAFITTVTFLWKVSAITVVSCL-PLYVLKY--------LKRKLSPPSYSKLSS 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	124/414 (30%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	184/592 (31%)
Atp9b	XP_017456363.1	P-type_ATPase_APLT_Neo1-like	132..1067	CDD:319841	342/1329 (26%)
		Cation_ATPase	560..671	CDD:463817	35/110 (32%)