Protein Alignment ATP8B and Atp8a1

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_038948654.1
• Gene: Atp8a1 / 289615
• RGDID: 1309619
• Length: 1209
• Species: Rattus norvegicus
• Alignment Length: 1571
• Identity: 513/1571 - (32%)
• Similarity: 726/1571 - (46%)
• Gaps: 438/1571 - (27%)

  Fly    96 PERRNSDLEGSPRACLAQPEGMNIGSSTQTIATPLMIGDSFYSLAPGG-------------GNPP 147
            ||...:.|  |..|||.   |.:: .||..:.|.:.:.:: .|.|||.             ...|
  Rat     3 PEEEATTL--SFGACLL---GKHL-LSTCCLLTGVEMSNT-PSRAPGSSYSGTGRLTHNQRARKP 60

  Fly   148 P--NKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFKYH 210
            |  .|:||           .||..|:..                .|..|.|..|..:..   |:.
  Rat    61 PGYEKTDD-----------VSEKTSLAD----------------QEEVRTIFINQPQLT---KFC 95

  Fly   211 NNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVK 275
            ||::.|:||::.||||..|..||:|.||.:||.:.:||.||.:|.....||.:||:.:|.:.|:|
  Rat    96 NNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIK 160

  Fly   276 DAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGL 340
            :..:||:||.:|:.||.::::.||||......|.:|.|||::.:...:|:.|||:|||:|||..:
  Rat   161 EIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEFIPADTVLLSSSEPQAM 225

  Fly   341 CFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFA 404
            |:|||:.||||||||.:|.|..|.::.| .|||...:|.|.||.||..|..|.|.:...|. ...
  Rat   226 CYIETSNLDGETNLKIRQGLPATSDIKD-IDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVP 289

  Fly   405 LDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSIC 469
            |..::|||||..||||||.:|:||:.|.||||||||.....|.:.|:|:.|..|:.:...|:::.
  Rat   290 LGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMS 354

  Fly   470 ALFAIGCAIWEGL-IGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSV 533
            .:.::|.|||... .|:.:.|:|.:          .||:..| |.|.::.|:.|.::||||.|::
  Rat   355 LVCSVGSAIWNRRHSGKDWYLHLHY----------GGASNFG-LNFLTFIILFNNLIPISLLVTL 408

  Fly   534 EVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSING 598
            ||::|.|::.||||.:|:|..|:|.|.|||:.|||||||::|||||||||||.|:|.|.||:|.|
  Rat   409 EVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAG 473

  Fly   599 RSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSM 663
            .:||.|                          |.|
  Rat   474 VAYGHV--------------------------PEP------------------------------ 482

  Fly   664 VVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLS 728
                                                          :|.             |.|
  Rat   483 ----------------------------------------------EDY-------------GCS 488

  Fly   729 PPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFK 793
            |
  Rat   489 P---------------------------------------------------------------- 489

  Fly   794 KAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANP 858
                               ||                        |.||       |..|
  Rat   490 -------------------DE------------------------WQSS-------QFGD----- 499

  Fly   859 HHESDFRWYDRTLLDAVRSDEEHSHV---FFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAA 920
              |..|.  |.:||:.::::...:.:   |..::|:|||.:.|....|:.|||.||||.|||.||
  Rat   500 --EKTFN--DPSLLENLQNNHPTAPIICEFLTMMAVCHTAVPERDGEKIIYQAASPDEGALVRAA 560

  Fly   921 RNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYD 984
            :...|||..|||:|:.|:.:||.|.|||||:|:|.:.||||||::|. ...:.|||||||.|||:
  Rat   561 KQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSSRKRMSVVVRTPSGKLRLYCKGADTVIYE 625

  Fly   985 RLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIY 1049
            || ......|..|..||.:||.||||||..|...::|..:.:||:..|.|:.|:.:|..||...|
  Rat   626 RL-AESSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEEWRAVYQRASTSVQNRLLKLEESY 689

  Fly  1050 EEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADV 1114
            |.||..:||:|.|||||||||.||::|..|..|.||||:|||||||||||||:||:||...:..:
  Rat   690 ELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCRLLRRNMGMI 754

  Fly  1115 FIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLP 1179
            .|.:|                                      ::|....|:
  Rat   755 VINEG--------------------------------------SLDGTRETL------------- 768

  Fly  1180 PTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGH 1244
                                        |..|..| ||....|:            .|||:::|.
  Rat   769 ----------------------------SRHCTTL-GDALRKEN------------DFALIIDGK 792

  Fly  1245 SLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAA 1309
            :|.:.|:..:...|||:|..|||||||||:||||:.|||::|:....:||||||||||||||:.|
  Rat   793 TLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVITLAIGDGANDVSMIQTA 857

  Fly  1310 HIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYS 1374
            |:||||||.|||||..|||||||||:||:.||:|||.|:|.|:.|.:.|.||||....:...|::
  Rat   858 HVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYNRVSKCILYCFYKNIVLYIIEIWFA 922

  Fly  1375 LFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFI 1439
            ...|||.|.:|:...|.:||:.:|::|.|.||:||:....:|.|::|.||.....:..||.:.|.
  Rat   923 FVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFW 987

  Fly  1440 YSVLHGAFTSLVLFLIPYGVYKDG-VSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVV 1503
            ...|:|.|.|::||..|....:.| |..|| ..||::.||..|.|.:::....:..|.|||||..
  Rat   988 VHCLNGLFHSVILFWFPLKALQYGTVFGNG-KTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWF 1051

  Fly  1504 NHVTIWGSLVWYFVLDYFYNYVIGGPYV-------GSLTQAMKDLTFWVTML-ITVMALVAPVLA 1560
            :|:.||||:..:.|  :|..|....|.|       |..........|||.:| |.|.:|:..||
  Rat  1052 SHIAIWGSIALWVV--FFGIYSSLWPAVPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVL- 1113

  Fly  1561 YKFYLLDVHPSLSDKI---------------------RQKSLKKIHSRASSDVRRTASSRRGRRS 1604
            ||........:|.|::                     |.:.||.:..:...::.|:.|.   :::
  Rat  1114 YKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESL---QQN 1175

  Fly  1605 VRSGYAFAHQE 1615
            :..||||:..|
  Rat  1176 LLHGYAFSQDE 1186

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	174/392 (44%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	239/571 (42%)
Atp8a1	XP_038948654.1	ATPase-Plipid	94..1131	CDD:273734	475/1383 (34%)