Protein Alignment ATP8B and CG33298

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1670
• Identity: 486/1670 - (29%)
• Similarity: 776/1670 - (46%)
• Gaps: 342/1670 - (20%)

  Fly    27 GGQPIETELQEDNERTPTKGAGNVDEPGIEAPEASCSAPSKRTRWFQFARSSKNRRKRLHCNEDE 91
            ||.|:...         ..|.|....||:     :.:|||:     ..|||..:....:......
  Fly    73 GGNPVVGS---------APGGGGQGIPGV-----AMAAPSR-----GHARSISHGGGAIVGANGR 118

  Fly    92 DVKQPERRNSDLEGSPRAC-----------LAQPEG---MNIGSSTQTIATPLMIG--------D 134
            .:|      |.::|..||.           .|.|.|   ..:||.|..|..|   |        .
  Fly   119 PIK------SAMKGHQRAFSQGQITDSPPGSAAPAGRGHSRVGSKTDFILPP---GHKEEPAREP 174

  Fly   135 SFYSLAPGGGNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRAN 199
            |..:.|.||.......|..:.:|..|      .:::.|..:||:.........:...:.|.:..|
  Fly   175 SAPTSATGGRGHSRQASRSESIYTLR------RTEAPPWWKRLTLCNYNTGDKFEERSYRTVVPN 233

  Fly   200 -------DKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT 257
                   .|..:...::..|.|:|:||:|.:|:|.||||||.|:||.||:.:::|..:|.||:..
  Fly   234 HTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPEISAFG 298

  Fly   258 PVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTL--RNGKLVEAKWSEVQVGDVIRLD 320
            .....||::.||.:|||||.::|.:|..||.::||...:..  ...:..:.||.|::|||::.|.
  Fly   299 KEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGDIVHLS 363

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLW---NFNGEIIC 382
            ||:.|.||.|||.||:|.|:|:|:|.:||||||||.:    |.:...:...|::   .|...:..
  Fly   364 NNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRR----EVVRGFEEMQSIFVPSKFVSRVEA 424

  Fly   383 ERPNNLLNKFDGTLIW-RGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFK 446
            :.|...|.:|.|.||. .|:|..:..|.:|||...|:||.:..|:||:||.:||.|.|:...::|
  Fly   425 DAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRYK 489

  Fly   447 STGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTG---ATV 508
            .:.|::.:|..:|..|:.|:.:|.:.||||.:|.... .||          |..|:|..   |.:
  Fly   490 RSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSF-THF----------PVPYLPPNKLTANM 543

  Fly   509 IGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQI 573
            ..:.:|::|.::|..::|:||||::|:.:.:|.|.|:.:.:::...||...:.|...:.||||||
  Fly   544 ESMWIFWTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQI 608

  Fly   574 QYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAI 638
            |:||:|||||||:|.|.|.:|.:||..|                          |:.||.|. .|
  Fly   609 QHIFTDKTGTLTENKMIFRRCVVNGSDY--------------------------NHPPSELE-KI 646

  Fly   639 VAPPAAPPPIILVH------KAEV--------HAKKTS--MVVTSSGEAQVLPDRPRSDIERSAP 687
            .:.|.||.|.::.:      .|::        ||::..  :||.:.....::...|..|:
  Fly   647 YSKPGAPAPPLIPNDNLNSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDM----- 706

  Fly   688 PMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQR 752
             |:||    |:..|:                           .:||....:..|.:|      |:
  Fly   707 -MNAS----GIIEVQ---------------------------QIGNSPANLKHGKQR------QK 733

  Fly   753 QLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPS--------------TATLGV 803
            .|:.::|......:.:...|:...:...:....||.:.| ...||              ..||..
  Fly   734 LLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESR-SVTPSPPPNLLFALPAQSHQPTLSP 797

  Fly   804 VISQLEHHLDEEPQSTS------TLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHES 862
            :.|..|...:.|.:|.|      :||.:.....|:||...:         .:.|:
  Fly   798 ISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINS---------KITSI---------- 843

  Fly   863 DFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVF 927
                  .|.|:|....:.     .:|.:.....:..|.||:..|:|:||||.|||:||.::....
  Fly   844 ------ATFLNAKTQGKR-----MKLPSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCL 897

  Fly   928 RTRTPNSITIE--VMGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDRL-- 986
            ..|:||.|.:.  :.|.|.|||:|.:|.|::.||.||:::|:  ...:|||.||||:.|...|
  Fly   898 LNRSPNQILVSMPMAGATREYEILKVLPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVP 962

  Fly   987 --HGGQED-LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAI 1048
              |...|. |:.:||..|:::|.||||.|.:|:|.|....|.||.:|.||..:|:::||::|...
  Fly   963 CSHNSPEGILREQTQQLLDRYAREGLRILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDS 1027

  Fly  1049 YEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELAD 1113
            :.::||.:.|:|.|.|||:||||||::||:|.:|||.:|||||||.||||||.||.:|.|.::
  Fly  1028 FAKLESNLTLLGATGIEDRLQDGVPETIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQM-- 1090

  Fly  1114 VFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNL 1178
                                |.|::..|.|.......:...:|...|..:.|:....:..::..
  Fly  1091 --------------------ELIRLTARSRDAAETAINFYLTDMENDKTTSTLGYGQSLRKKQR- 1134

  Fly  1179 PPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNG 1243
                                                                       ||||:|
  Fly  1135 -----------------------------------------------------------ALVVDG 1140

  Fly  1244 HSLVHCLSP--ELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMI 1306
            .:|...|.|  :|...||.::.:|.:|:|||.||||||.:|:::|...|..||||||||||||||
  Fly  1141 KTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVKVVKEELNLRTLAIGDGANDVSMI 1205

  Fly  1307 KAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHC 1371
            :.|.:|||||||||:|||:::|:::.:|||||||||.||.|.|.|:.:.:.||||||.||.....
  Fly  1206 QMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWCYDRLSRMILYFFYKNAAFVFLIF 1270

  Fly  1372 WYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIR 1436
            ||.|:||||.|.:.|.|::.:|||.:||||.||:||:::.|::...|:.|.||..|.....:...
  Fly  1271 WYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVAEDLLLKNPYLYKNGRLGVAYRPH 1335

  Fly  1437 EFIYSVLHGAFTSLVLFLIPYGVYKD---GVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTS 1498
            :|...:|...:.|||:|.:....|.:   |:          ...|..:....:..|....::...
  Fly  1336 DFWLILLDALYQSLVIFFVALCAYAESDVGI----------WEFGTTITASCLFANLVHCAIEIR 1390

  Fly  1499 YWTVVNHVTIWGSLVWYFVLDYFYNYV------IGGPYVGSLTQAMKDLTFWVTMLITVMALVAP 1557
            .|||::.::|..||..:::....|:.|      :...| ..:.........|:.::::.:..|.|
  Fly  1391 SWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSY-WVIFVCFASAVHWLVIMLSTVVAVLP 1454

  Fly  1558 VLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDV----RRTASS 1598
            .|......:.:.|..|.|:..:| |:..||..:.:    |.|::|
  Fly  1455 RLLLTTVRISLCPDDSTKVILQS-KRERSRGEALLVTWSRSTSAS 1498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	150/399 (38%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	218/581 (38%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	419/1300 (32%)