Protein Alignment ATP8B and SPAC24B11.12c

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_592849.1
• Gene: SPAC24B11.12c / 2541560
• PomBaseID: SPAC24B11.12c
• Length: 1402
• Species: Schizosaccharomyces pombe
• Alignment Length: 1597
• Identity: 465/1597 - (29%)
• Similarity: 707/1597 - (44%)
• Gaps: 503/1597 - (31%)

  Fly   155 ELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFN----AQFKYHNNYIK 215
            |.|...||.         |||.|.::.|   :.||.     :...|.|.:    |:..:..|.|:
pombe    44 EEYDGSDPQ---------SLRGLQKLPR---TLYFG-----LPLPDSELDDTGEAKRWFPRNKIR 91

  Fly   216 TSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAI-SSLTPVTTAIPLIGVLTLTAVKDAYD 279
            |:||:...|:|.|:..|||.:||.:||.|::||.|... ..:.|...|:|||.|:.:||||||.:
pombe    92 TAKYTPIDFIPKNIFLQFQNVANLFFLFLVILQSISIFGEQVNPGLAAVPLIVVVGITAVKDAIE 156

  Fly   280 DIQRHISDSQVNN-------------------------------------------RKSKTLRNG 301
            |.:|.:.|..:||                                           :::|.|.:.
pombe   157 DFRRTMLDIHLNNTPTLRLSHYQNPNIRTEYISYFRRFKKRISALFRVFLAKQEEKKRAKRLNDA 221

  Fly   302 --------------------KLVEAK--------------------------------------- 307
                                :..|||
pombe   222 VPLEDMAGSESRPSYDSIFRESFEAKRSFEDSKGKVPLSALDGTATILQSRPMDIIDYEAEATGE 286

  Fly   308 -------WSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLT---- 361
                   |.:|:|||.:::.:|..:.||.:::::|:|.|:|:|||..||||||||.:..||
pombe   287 CHFKKTYWKDVRVGDFVKVMDNDEIPADIVIINSSDPEGICYIETKNLDGETNLKMRHALTCGKN 351

  Fly   362 ---ET--------IELGDRHDSLWNFNGEIICERPNNLLNKFDG---TLIWRGQRFALDNEKILL 412
               |.        ||....|.:|:.:||  .|:   :.::...|   |.....:..:||:  :||
pombe   352 VVDEASCERCRFWIESEPPHANLYEYNG--ACK---SFVHSEAGGSDTSQTVSEPISLDS--MLL 409

  Fly   413 RGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCA 477
            ||||||||:|..|||||.|.|||:|.|||....|.:.:.|.||:.:....:.|.|:|.:    ||
pombe   410 RGCVLRNTKWVIGVVVFTGDDTKIMLNSGAPPLKRSRITRNLNWNVYLNFIILFSMCFV----CA 470

  Fly   478 IWEGLIGQHFQLYLPWE-HIIPKDYIPTGA-----TVIGLLVFFSYAIVLNTVVPISLYVSVEVI 536
            :.||         :.|. |.....|...|:     ...|::.||:..|:...:||||||:|:|::
pombe   471 VVEG---------IAWRGHSRSSYYFEFGSIGGSPAKDGVVTFFTGVILFQNLVPISLYISIEIV 526

  Fly   537 RFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSY 601
            :.:|:..|.:|::|||.........::..::::|||::|||||||||||||:|.|.||:|||.:|
pombe   527 KTIQAIFIYFDKDMYYKKLKYACTPKSWNISDDLGQVEYIFSDKTGTLTQNVMEFKKCTINGVAY 591

  Fly   602 GDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVT 666
            |:.          .||
pombe   592 GEA----------FTE------------------------------------------------- 597

  Fly   667 SSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPV 731
                                                                             
pombe   598 ----------------------------------------------------------------- 597

  Fly   732 GNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAP 796
                 .::|..||.|....:..|.:.|..::.::...||.   .||    |:.|.||
pombe   598 -----AMAGMAKREGKDTEELTLQKQSFIERDRMQMISQM---RNM----HDNKYLV-------- 642

  Fly   797 STATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHE 861
             ...|..:.||..|.|
pombe   643 -DDNLTFISSQFVHDL------------------------------------------------- 657

  Fly   862 SDFRWYDRTLLDAVRSDEEHS---HVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNF 923
                        |.::.||.|   :.||..|||||:|:|:.|..::.|:||||||||||..||:.
pombe   658 ------------AGKAGEEQSLACYEFFLALALCHSVVADRVGDRIVYKAQSPDEAALVGTARDV 710

  Fly   924 GFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDS-MVLYCKGADNVIYDRLH 987
            ||||..:..:.:....:|:|:.::|::.::|::.|||||||::..|: .||.|||||::|::||.
pombe   711 GFVFLDQRRDIMVTRALGETQRFKLMDTIEFSSARKRMSVIVKGPDNRYVLICKGADSIIFERLE 775

  Fly   988 GGQE-DLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEE 1051
            ..:: :|:..|.:||..||.||||||.:|:|.|||:.|.:|:.:...||.::::||:::..:.:.
pombe   776 PNEQVELRKTTSEHLRIFALEGLRTLCIAKRELTEEEYYEWKEKYDIAASAIENREEQIEEVADL 840

  Fly  1052 IESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADV-- 1114
            |||.:.|:|.|||||:||:|||.|||.|..||||:|||||||.|||||||:||.|| |...|:
pombe   841 IESHLTLLGGTAIEDRLQEGVPDSIALLAQAGIKLWVLTGDKMETAINIGFSCNLL-DAGMDMIK 904

  Fly  1115 FIVDGN-SVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNL 1178
            |.||.. |..|:|..|..:     :|..|...|
pombe   905 FDVDQEVSTPELEVILADY-----LYRYFGLSG-------------------------------- 932

  Fly  1179 PPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNG 1243
                      ||......:|:.|...|                              ..|||::|
pombe   933 ----------SVEELEAAKKDHDTPSG------------------------------SHALVIDG 957

  Fly  1244 HSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKA 1308
            ..|...|...:..|||.:..:||||:||||:|.|||.||:|::.:...:|||||||||||:||:.
pombe   958 SVLKRVLDGPMRTKFLLLCKRCKAVLCCRVSPAQKADVVQLVRESLEVMTLAIGDGANDVAMIQK 1022

  Fly  1309 AHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWY 1373
            |.|||||.|:||..|.:|:||:|.|||:|.:|:||||||.|.|:.:.:..||||:..:|....||
pombe  1023 ADIGVGIVGEEGRAAAMSADYAIGQFRFLSKLVLVHGRWDYNRVAEMVNNFFYKSVVWTFTLFWY 1087

  Fly  1374 SLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIRE- 1437
            .::..|.|..:||..::.::||.::||||:.:||::|||:...||..|:||..|: .:|.:.|:
pombe  1088 QIYNNFDANYLFDYTYVMLFNLIFSSLPVIVMGVYDQDVNADLSLRIPQLYKRGI-LQLNSARKI 1151

  Fly  1438 FIYSVLHGAFTSLVLFLIPYGVYKDGVSA--NG---FVVSDHMTLGAVVA--TILIVDNTAQISL 1495
            ||..:|.|.:.|::.|...:.|..:..:|  ||   ..|.|   ||..||  ||::||  ..:.|
pombe  1152 FIGYMLDGFYQSVICFFFSFLVINNVTTAAQNGRDTMAVQD---LGVYVAAPTIMVVD--TYVIL 1211

  Fly  1496 YTSYWTVVNHVTIWG---SLVWYFVLDY---FYNYVIGGPYVGSLTQAMKDLTFWVTMLITVMAL 1554
            ..|.|.|.: :.:|.   ...|::...|   .|.|    .:..|.::..:...||..:..|:::.
pombe  1212 NQSNWDVFS-IGLWALSCLTFWFWTGVYSQSLYTY----EFYKSASRIFRTPNFWAVLCGTIVSC 1271

  Fly  1555 VAPVLAYK-----FYLLDVHPSLSDKIRQK-SLKKIH 1585
            :.|...:.     |:..||     |.||:. ..|::|
pombe  1272 LFPKFLFMTTQKLFWPYDV-----DIIRESYRTKRLH 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/69 (33%)
		Cation_ATPase	891..985	CDD:289987	43/94 (46%)
		HAD_like	<1261..1324	CDD:304363	37/62 (60%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	84/265 (32%)
SPAC24B11.12c	NP_592849.1	ATPase-Plipid	85..1295	CDD:273734	448/1529 (29%)
		PhoLip_ATPase_N	<85..129	CDD:292826	19/43 (44%)
		Cation_ATPase	678..773	CDD:289987	43/94 (46%)
		COG4087	<989..1045	CDD:226572	33/55 (60%)
		PhoLip_ATPase_C	1038..1287	CDD:292829	82/259 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810