Protein Alignment ATP8B and SPBC887.12

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_596486.1
• Gene: SPBC887.12 / 2541239
• PomBaseID: SPBC887.12
• Length: 1258
• Species: Schizosaccharomyces pombe
• Alignment Length: 1638
• Identity: 496/1638 - (30%)
• Similarity: 729/1638 - (44%)
• Gaps: 482/1638 - (29%)

  Fly    78 SKNRRKRLHCNEDED-----------VKQP---ERRNSDLEGSPRACLAQPEGMNIGSSTQTIAT 128
            :|...||:..:||||           :..|   |....|:.||        |...|.||.|....
pombe     7 NKQNAKRISRDEDEDEFAGESMVGRTLDNPFLGEDEFEDIFGS--------ESQYISSSGQNSTN 63

  Fly   129 PLMIGDSFYSLAPGGGNPPPNKSDDQ---------ELYKQRDPSVTSESKSVPSLRRLSQIRRRR 184
            | .:.|:....:|.|.....|:.:.|         .|....||  |.....:|..:.....|.::
pombe    64 P-FLADTRIENSPLGSESKANQLNKQGTNVNHIEIPLRDFNDP--TQPESFLPPPKNTFTSRIKK 125

  Fly   185 SSYYFSENERRIRAND--------KEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYF 241
            ....|.:.:::::..|        .:::|....| |.:.|.|||.|||||..|.|||.:.||.:|
pombe   126 IKNLFKKEKKQVKPEDLGPRQIILNDYSANHFLH-NAVSTCKYSAFTFLPKFLKEQFSKYANLFF 189

  Fly   242 LCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEA 306
            |...|:|.||.|:.:...||..|::.||:::.:|:..:||:|...|.::|......|:....||.
pombe   190 LFTAVVQQIPGITPVNRYTTIGPMLIVLSVSGIKEIMEDIKRKKQDQELNESPCYVLQGTGFVEK 254

  Fly   307 KWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTET------IE 365
            :|.:|.|||::::.:..|..||.:|||:|||.|||:||||.||||||||.||.|.||      :|
pombe   255 QWKDVVVGDIVKIVSETFFPADLVLLSSSEPEGLCYIETANLDGETNLKIKQALPETAGLLKPVE 319

  Fly   366 LGDRHDSLWNFNGEIICERPNNLLNKFDGT--LIWRGQRFALDNEKILLRGCVLRNTQWCYGVVV 428
            ||       ..:||:..|:|||.|..||.|  |:...:...|..:::||||..||||.|.||:||
pombe   320 LG-------QLSGEVKSEQPNNNLYTFDATLKLLPSDRELPLSPDQLLLRGAQLRNTPWVYGIVV 377

  Fly   429 FAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPW 493
            |.|.::|||:|:.:|..|.|.|::.:|..|:.::...|.:|...::|..|...:.|...
pombe   378 FTGHESKLMKNTTETPIKRTSVEKQVNSQILFLLCIFVFLCFASSLGALIHRSVYGSAL------ 436

  Fly   494 EHIIPKDYIP-----TGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYP 553
                  .|:.     .|....|||.|:   |:.:.:|||||:|:.|::|::|:.||:.|.:||..
pombe   437 ------SYVKYTSNRAGMFFKGLLTFW---ILYSNLVPISLFVTFELVRYIQAQLISSDLDMYNE 492

  Fly   554 TTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQ 618
            .|:|.|..||::|.|||||:.|||||||||||:|.|.|.:|:|.|.:|.|||
pombe   493 ETDTPAACRTSSLVEELGQVGYIFSDKTGTLTRNQMEFRQCTIAGVAYADVI------------- 544

  Fly   619 QTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIE 683
                                                                             
pombe   545 ----------------------------------------------------------------- 544

  Fly   684 RSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAG 748
                                                                             
pombe   545 ----------------------------------------------------------------- 544

  Fly   749 CMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLD 813
                                                                            .
pombe   545 ----------------------------------------------------------------P 545

  Fly   814 EEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSD 878
            |:.|.||                             :.:|        ||...||   .|.::.:
pombe   546 EDRQFTS-----------------------------EDLD--------SDMYIYD---FDTLKEN 570

  Fly   879 EEHS------HVFFRLLALCHTVMAETVD--GKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSI 935
            .:||      |.|..:|::||||:.|..:  ..::|||.||||.|||..|.:.|:.|..|.|:.:
pombe   571 LKHSENASLIHQFLLVLSICHTVIPEYDESTNSIKYQASSPDEGALVKGAASIGYKFLARKPHLV 635

  Fly   936 TIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV-LYCKGADNVIYDRLHGGQEDLKARTQD 999
            |:.:.|:.|.||||:|.:||:.|||||::.|..|..: ||.||||.||.:||......|:. |..
pombe   636 TVSIFGKDESYELLHICEFNSTRKRMSIVFRCPDGKIRLYVKGADTVIMERLASDNPYLQT-TIH 699

  Fly  1000 HLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAI 1064
            ||..:|..|||||.:|.|.:.|..|..|.:..:.||.|:..|.|||....||||.::.|:|.|||
pombe   700 HLEDYATVGLRTLCIAMREVPEDEYQRWSTVFETAASSLVDRAQKLMDAAEEIEKDLILLGATAI 764

  Fly  1065 EDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQL 1129
            ||:||||||.:|:.||.|||||||||||:||||||||.||:|:.:::..|.:
pombe   765 EDRLQDGVPDTISTLQTAGIKIWVLTGDRQETAINIGMSCKLIDEDMGLVIV------------- 816

  Fly  1130 RQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFR 1194
                                                                             
pombe   817 ----------------------------------------------------------------- 816

  Fly  1195 WDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFL 1259
             :|:.|:.......|:.::::.:|  :..|...|:        |||::|.||.:.|...||.:|.
pombe   817 -NEETKEATAESVMAKLSSIYRNE--ATTGNVESM--------ALVIDGVSLTYALDFSLERRFF 870

  Fly  1260 DIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAV 1324
            ::||.|:|||||||:||||||:|:::||....|.||||||||||.||:|||:||||||.||||||
pombe   871 ELASLCRAVICCRVSPLQKALIVKMVKRNTGEVLLAIGDGANDVPMIQAAHVGVGISGMEGLQAV 935

  Fly  1325 LSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMF 1389
            .|||:||:||.||::||||||.|.|.|:.|.:.|.||||.|..:...||:....||.|.:|:...
pombe   936 RSSDFSISQFCYLKKLLLVHGSWCYQRLSKLILYSFYKNIALYMTQFWYAFCNAFSGQVIFESWS 1000

  Fly  1390 ISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFL 1454
            ||:||:.:|.||.:.:|:|:|.||.....::|:||..|.:||.||::.|...:.:|.:.||:|||
pombe  1001 ISLYNVLFTVLPPVVIGIFDQFVSAGQLFQYPQLYQLGQRSEFFNLKRFWSWITNGFYHSLLLFL 1065

  Fly  1455 IPYGV-YKDGVSANGFVVSDHMTLG-----AVVATILIVDNTAQISLYTSYWTVVNHVTIWGS-L 1512
            ....| |.||.:.:| :.|.|...|     |::||:|     .:.:|.:::||....:...|| |
pombe  1066 CSIAVFYYDGPNKDG-LASGHWVWGTTLYAAILATVL-----GKAALISNHWTQYTVIATLGSFL 1124

  Fly  1513 VWYFVLDYFYNYVIGGP-------YVGSLTQAMKDLTFWVTMLI--TVMALVAPVLAY------- 1561
            :|...:..   |.:..|       |.|.:.....:|.||.::|:  |:..:...|..|
pombe  1125 LWIVFMPI---YAVAAPAIGFSKEYYGIIPHLYGNLKFWASLLVLPTIALMRDFVWKYSSRMYYP 1186

  Fly  1562 ----------KFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAH-QE 1615
                      |:.:.|..|.:..  ..|:::||        |:....|:.|     ||||:. :|
pombe  1187 EEYHYVQEIQKYNVTDYRPRIVG--FHKAIRKI--------RQMQRMRKQR-----GYAFSQGEE 1236

  Fly  1616 GFGRLITSGKIMH 1628
            ...|::.:....|
pombe  1237 DQSRILDAYDTTH 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/72 (36%)
		Cation_ATPase	891..985	CDD:289987	45/96 (47%)
		HAD_like	<1261..1324	CDD:304363	45/62 (73%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	91/279 (33%)
SPBC887.12	NP_596486.1	PhoLip_ATPase_N	147..208	CDD:292826	25/61 (41%)
		ATPase-Plipid	157..1194	CDD:273734	448/1405 (32%)
		E1-E2_ATPase	213..>307	CDD:278548	41/93 (44%)
		Cation_ATPase	590..686	CDD:289987	45/95 (47%)
		HAD_like	<736..935	CDD:304363	109/287 (38%)
		PhoLip_ATPase_C	935..1186	CDD:292829	89/259 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
TreeFam	0	0.000	Not matched by this tool.
	6	5.720