DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and ATP11A

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_005268356.1	Gene:	ATP11A / 23250	HGNCID:	13552	Length:	1192	Species:	Homo sapiens

Alignment Length:	1427	Identity:	396/1427 - (27%)
Similarity:	634/1427 - (44%)	Gaps:	394/1427 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTL 271
            :|.:|.|.:|||:.:.|:|.||.|||:|:||||||.:.::|||  |.:.| |||:.:||..|:|:
Human    44 RYPDNRIVSSKYTFWNFIPKNLFEQFRRVANFYFLIIFLVQLI--IDTPTSPVTSGLPLFFVITV 106

  Fly   272 TAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            ||:|..|:|..||.:|:.:|......:::||||..:..:::|||::.:..::....|.:.||::.
Human   107 TAIKQGYEDWLRHKADNAMNQCPVHFIQHGKLVRKQSRKLRVGDIVMVKEDETFPCDLIFLSSNR 171

  Fly   337 PNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTL----- 396
            .:|.|.:.||.||||::.|....:.:|.......| :...:..|.||:|...|.||.|.:
Human   172 GDGTCHVTTASLDGESSHKTHYAVQDTKGFHTEED-IGGLHATIECEQPQPDLYKFVGRINVYSD 235

  Fly   397 ----IWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFI 457
                :.|    .|.:|.:||||..|:||:..:||.::.|::||:..|......|.:.|::.:|..
Human   236 LNDPVVR----PLGSENLLLRGATLKNTEKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNAF 296

  Fly   458 IIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLN 522
            :|..:..|:|...:..:...:|:   .:.|: ..||.:...:........:.....|.::.::.|
Human   297 LIVYLCILISKALINTVLKYMWQ---SEPFR-DEPWYNQKTESERQRNLFLKAFTDFLAFMVLFN 357

  Fly   523 TVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQN 587
            .::|:|:||:||:.:|:.|:.|.|||:|:...|.......|:.|||||||::|||:|||||||:|
Human   358 YIIPVSMYVTVEMQKFLGSYFITWDEDMFDEETGEGPLVNTSDLNEELGQVEYIFTDKTGTLTEN 422

  Fly   588 IMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVH 652
            .|.|.:|.|.|..|                                           .|.:|.
Human   423 NMEFKECCIEGHVY-------------------------------------------VPHVIC-- 442

  Fly   653 KAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRL 717
                             ..||||:....|:..|:|.::                        ||
Human   443 -----------------NGQVLPESSGIDMIDSSPSVN------------------------GR- 465

  Fly   718 SPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSH 782

Human   466 ----------------------------------------------------------------- 465

  Fly   783 NRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVH 847

Human   466 ----------------------------------------------------------------- 465

  Fly   848 ALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA---ETVDGKLE---- 905
                                            |...:|||.|.|||||..   ::|||..:
Human   466 --------------------------------EREELFFRALCLCHTVQVKDDDSVDGPRKSPDG 498

  Fly   906 -----YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQ---TEEYELLNILDFNNVRKRMS 962
                 |.:.||||.|||...:..||.:.....|  .:|::.:   .|.:|||.||.|::||:|||
Human   499 GKSCVYISSSPDEVALVEGVQRLGFTYLRLKDN--YMEILNRENHIERFELLEILSFDSVRRRMS 561

  Fly   963 VILRRGDSMV-LYCKGADNVIYDRLHGGQED-LKARTQDHLNKFAGEGLRTLALAERRLTEQYYN 1025
            ||::.....: |:|||||:.|:.|:..|:.| ::||.:    :.|.||||||.:|.:||.::.|.
Human   562 VIVKSATGEIYLFCKGADSSIFPRVIEGKVDQIRARVE----RNAVEGLRTLCVAYKRLIQEEYE 622

  Fly  1026 DWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLT 1090
            ......|.|.:::..||:||...||:||.::.|:|.||:||:||:....:|..||.||||:||||
Human   623 GICKLLQAAKVALQDREKKLAEAYEQIEKDLTLLGATAVEDRLQEKAADTIEALQKAGIKVWVLT 687

  Fly  1091 GDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNS 1155
            |||.|||....|:|:|                      .|:..:.:::..:          |:..
Human   688 GDKMETAAATCYACKL----------------------FRRNTQLLELTTK----------RIEE 720

  Fly  1156 DSNMD---PLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGD 1217
            .|..|   .||.|:.:.|..:...||
Human   721 QSLHDVLFELSKTVLRHSGSLTRDNL--------------------------------------- 746

  Fly  1218 EKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENK-------FLDIASQCKAVICCRVTP 1275
                  .|.::.:.|    :.|:::|.:|...:.|..:..       ||:|...|.||:|||:.|
Human   747 ------SGLSADMQD----YGLIIDGAALSLIMKPREDGSSGNYRELFLEICRSCSAVLCCRMAP 801

  Fly  1276 LQKALVVELIKRAK-NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLER 1339
            ||||.:|:|||.:| :.:||||||||||||||..||:|:|:.|:||.||..:|||:|.:|::|::
Human   802 LQKAQIVKLIKFSKEHPITLAIGDGANDVSMILEAHVGIGVIGKEGRQAARNSDYAIPKFKHLKK 866

  Fly  1340 LLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLA 1404
            :|||||.:.|.|:.:.::||||||..|......|..|||||.||::|..::::||:.:||||:|.
Human   867 MLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFSQQTLYDTAYLTLYNISFTSLPILL 931

  Fly  1405 LGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKD-GVSANG 1468
            ..:.||.|........|.||....|:.|...|.|||..|.|.|.:||.|...|.|::: .|::||
Human   932 YSLMEQHVGIDVLKRDPTLYRDVAKNALLRWRVFIYWTLLGLFDALVFFFGAYFVFENTTVTSNG 996

  Fly  1469 FVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVG- 1532
            .:.. :.|.|.:|.|:::...|.:::|.|.|||.:||..|||||::|.|....:..|| .|::.
Human   997 QIFG-NWTFGTLVFTVMVFTVTLKLALDTHYWTWINHFVIWGSLLFYVVFSLLWGGVI-WPFLNY 1059

  Fly  1533 -----SLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRAS 1589
                 ...|.:.....|:.:::.|...:.|.:..|.....:.|:.:::::|....:...|.|
Human  1060 QRMYYVFIQMLSSGPAWLAIVLLVTISLLPDVLKKVLCRQLWPTATERVQQNGCAQPRDRDS 1121

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/52 (50%)
		Cation_ATPase	891..985	CDD:289987	41/109 (38%)
		HAD_like	<1261..1324	CDD:304363	39/63 (62%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	86/253 (34%)
ATP11A	XP_005268356.1	PhoLip_ATPase_N	42..95	CDD:292826	26/52 (50%)
		ATPase-Plipid	45..1110	CDD:273734	393/1413 (28%)
		E1-E2_ATPase	102..>187	CDD:278548	28/84 (33%)
		Cation_ATPase	477..585	CDD:289987	41/109 (38%)
		R3H	639..695	CDD:294210	31/55 (56%)
		HAD_like	<806..849	CDD:304363	26/42 (62%)
		PhoLip_ATPase_C	851..1103	CDD:292829	86/253 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.720