DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP11B

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:NP_055431.1 Gene:ATP11B / 23200 HGNCID:13553 Length:1177 Species:Homo sapiens


Alignment Length:1470 Identity:420/1470 - (28%)
Similarity:671/1470 - (45%) Gaps:413/1470 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   144 GNPPPNKSDDQELY-KQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQF 207
            |..||::||.:.:| ..|.|                     ::..|..:                
Human    10 GFDPPHQSDTRTIYVANRFP---------------------QNGLYTPQ---------------- 37

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLT-PVTTAIPLIGVLTL 271
            |:.:|.|.:|||:::.|:|.||.|||:|:||||||.:.::||:  |.:.| |||:.:||..|:|:
Human    38 KFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLM--IDTPTSPVTSGLPLFFVITV 100

  Fly   272 TAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSE 336
            ||:|..|:|..||.||::||......:|:|.||:.:...::|||::|:..::...||.:|||:..
Human   101 TAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDR 165

  Fly   337 PNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFN---GEIICERPNNLLNKFDGTLIW 398
            .:|.|.:.||.||||||||....:.||..|    .::.|.:   ..|.|::|...|.:|.|.:|.
Human   166 LDGSCHVTTASLDGETNLKTHVAVPETALL----QTVANLDTLVAVIECQQPEADLYRFMGRMII 226

  Fly   399 RGQR----FALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIII 459
            ..|.    ..|..|.:||||..|:||:..:||.|:.|::||:..|......|.:.|::.:|..:|
Human   227 TQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLI 291

  Fly   460 GIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTV 524
            ..::.|:|...:..|....|:.    ..:...||.:...:....:...:..:..|.::.::.|.:
Human   292 IYLVILISEAVISTILKYTWQA----EEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFI 352

  Fly   525 VPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIM 589
            :||||||:||:.:|:.||.|.||.::|:..::..|:..|:.|||||||::|:|:|||||||:|.|
Human   353 IPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEM 417

  Fly   590 TFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKA 654
            .|.:|||||..|.::    .|.||                            |..|.|       
Human   418 QFRECSINGMKYQEI----NGRLV----------------------------PEGPTP------- 443

  Fly   655 EVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSP 719
                                               |:||                          
Human   444 -----------------------------------DSSE-------------------------- 447

  Fly   720 RLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNR 784
                        ||                                                   
Human   448 ------------GN--------------------------------------------------- 449

  Fly   785 KRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHAL 849
                                              .|.||:..|.::.|              |..
Human   450 ----------------------------------LSYLSSLSHLNNLS--------------HLT 466

  Fly   850 QSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETV------DG------ 902
            .|..|..:|.:|::.             .:||. :||:.::|||||....|      ||      
Human   467 TSSSFRTSPENETEL-------------IKEHD-LFFKAVSLCHTVQISNVQTDCTGDGPWQSNL 517

  Fly   903 ---KLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVI 964
               :|||.|.||||.|||.||...|.||...:..::.::.:|:.|.|:||:||:|::.|:|||||
Human   518 APSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVI 582

  Fly   965 LR--RGDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDW 1027
            ::  .|:.: |:.|||::.|..:..||:.:   :|:.|:::||.:|||||.:|.|:.|.:.|.:.
Human   583 VQAPSGEKL-LFAKGAESSILPKCIGGEIE---KTRIHVDEFALKGLRTLCIAYRKFTSKEYEEI 643

  Fly  1028 RSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGD 1092
            ..|..||..::..||:||.|:::.||.::.|:|.||:||:|||.|.::|..|:.||||:||||||
Human   644 DKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGD 708

  Fly  1093 KQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDS 1157
            |.|||:::..||......:..:.:::..|..|..:||||....|                     
Human   709 KHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRI--------------------- 752

  Fly  1158 NMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSE 1222
                                                                             
Human   753 ----------------------------------------------------------------- 752

  Fly  1223 DGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK- 1286
               |...|:..    .|||:|.||...|. |.|..|:::...|.||:|||:.|||||.|:.||| 
Human   753 ---TEDHVIQH----GLVVDGTSLSLALR-EHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKI 809

  Fly  1287 RAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYR 1351
            ..:..:|||:||||||||||:.||:|:||.|:||.||..:|||:||:|::|.:||.|||.:.|.|
Human   810 SPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIR 874

  Fly  1352 MCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKN 1416
            :...::||||||..|......|..:|.||.||::|.:::::||:.:||||:|...:.||.|....
Human   875 IATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHV 939

  Fly  1417 SLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVY----KD-GVSANGFVVSDHMT 1476
            ....|.||....|:.|.:|:.|:|..:.|...:.:.|   :|.|    || .:..||.:.. :.|
Human   940 LQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFF---FGSYLLIGKDTSLLGNGQMFG-NWT 1000

  Fly  1477 LGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGS------LT 1535
            .|.:|.|::::..|.:::|.|.:||.:||:..|||:::|||...||..:: .|::||      ..
Human  1001 FGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGIL-WPFLGSQNMYFVFI 1064

  Fly  1536 QAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDK 1575
            |.:...:.|..:::.|:..:...:..|.:...:||:.::|
Human  1065 QLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEK 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 25/65 (38%)
Cation_ATPase 891..985 CDD:289987 44/110 (40%)
HAD_like <1261..1324 CDD:304363 37/63 (59%)
PhoLip_ATPase_C 1324..1571 CDD:292829 81/257 (32%)
ATP11BNP_055431.1 PhoLip_ATPase_N 35..89 CDD:292826 25/71 (35%)
ATPase-Plipid 39..1106 CDD:273734 410/1404 (29%)
E1-E2_ATPase 96..>180 CDD:278548 32/83 (39%)
Cation_ATPase 494..605 CDD:289987 44/111 (40%)
HAD_like 629..868 CDD:304363 109/332 (33%)
PhoLip_ATPase_C 847..1100 CDD:292829 81/257 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.720

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