Protein Alignment ATP8B and ATP10B

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_079429.2
• Gene: ATP10B / 23120
• HGNCID: 13543
• Length: 1461
• Species: Homo sapiens
• Alignment Length: 1648
• Identity: 504/1648 - (30%)
• Similarity: 776/1648 - (47%)
• Gaps: 342/1648 - (20%)

  Fly   157 YKQRDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQF-----KYHNNYIKT 216
            ::.||......|::.|    |....:.|.||..:: :|.:..|:..|:..:     :|..|...|
Human    14 WRVRDGFPHCPSETTP----LLSPEKGRQSYNLTQ-QRVVFPNNSIFHQDWEEVSRRYPGNRTCT 73

  Fly   217 SKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDI 281
            :||:||||||.||.|||.|.||.|||.|::|..:|::.......|.:||..||.:..:||..:|.
Human    74 TKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIMIKDGMEDF 138

  Fly   282 QRHISDSQVN-------NRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNG 339
            :||..|..:|       .||.:|     .|:..|.:|:|||.|::..|:.|.||.|||.:|:|||
Human   139 KRHRFDKAINCSNIRIYERKEQT-----YVQKCWKDVRVGDFIQMKCNEIVPADILLLFSSDPNG 198

  Fly   340 LCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RF 403
            :|.:|||.|||||||| ::|:.:.....:.......|:..|:||:|||.||||.|.:....| |.
Human   199 ICHLETASLDGETNLK-QRCVVKGFSQQEVQFEPELFHNTIVCEKPNNHLNKFKGYMEHPDQTRT 262

  Fly   404 ALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGIVLFL 465
            ....|.:|||||.:|||:...|:|::||.:||.|.|:...::|.:.::|.:|   |..|||   |
Human   263 GFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMNIDIFFCIGI---L 324

  Fly   466 VSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLY 530
            :.:|.:.|:|.:||.|...:|....:|..:   ..::|  :.:.|..:|.:..|:|..::|||||
Human   325 ILMCLIGAVGHSIWNGTFEEHPPFDVPDAN---GSFLP--SALGGFYMFLTMIILLQVLIPISLY 384

  Fly   531 VSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCS 595
            ||:|:::..|.|.::.|.::|...|:...:.|...:.|:||||||||||||||||:|.|.|.:|:
Human   385 VSIELVKLGQVFFLSNDLDLYDEETDLSIQCRALNIAEDLGQIQYIFSDKTGTLTENKMVFRRCT 449

  Fly   596 INGRSYG---DVIDLRT-------GELVEITEQQTIFQNSNTNNRPSPLSGAIVAPP-----AAP 645
            |.|..|.   :...|.|       ||  |.|:.|.:..::.....|:.:.....|.|     :|.
Human   450 IMGSEYSHQENAKRLETPKELDSDGE--EWTQYQCLSFSARWAQDPATMRSQKGAQPLRRSQSAR 512

  Fly   646 PPIILVHKAEVHAKKTSM----------VVTSSGEAQVLPDRPRSDIERSAPPM--DASEKRPGL 698
            .||      :.|.::.||          ..:||.|..|.||:......|.|...  ..|:.||.
Human   513 VPI------QGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRPA- 570

  Fly   699 KHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSS---- 759
                                                                :..||.|||
Human   571 ----------------------------------------------------KASLSTTSSIADF 583

  Fly   760 ------CDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGV---VISQLEHHLDEE 815
                  |:.|.:   |..||.         |:| |.|:    ||:..||.   .|.||...|...
Human   584 FLALTICNSVMV---STTTEP---------RQR-VTIK----PSSKALGTSLEKIQQLFQKLKLL 631

  Fly   816 PQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFR---WYDRTLLDAVRS 877
            ..|.|..||........::...|.:::........||....:...:..:|   |....:|::...
Human   632 SLSQSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSG 696

  Fly   878 DEEHSHVFFRLLALCHTVMAETVDG--------KLEYQAQSPDEAALVSAARNFGFVFRTRTPNS 934
                            |.:.|.::.        :..|:|:||||||||.||..:.|...:|||..
Human   697 ----------------TSLEEALEAPATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQ 745

  Fly   935 ITIEV-MGQTEEYELLNILDFNNVRKRMSVILRR---GDSMVLYCKGADNVIYDRLHGGQED--- 992
            :|:.: .|....:.||..|.|::|||||||::|.   |: :|:|.||||:||.|.|    ||
Human   746 VTVRLPQGTCLTFSLLCTLGFDSVRKRMSVVVRHPLTGE-IVVYTKGADSVIMDLL----EDPAC 805

  Fly   993 ------------LKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL 1045
                        ::||||.||:.:|.:|||||.:|::.::|:.:..|.|.::||..|:|:|::.|
Human   806 VPDINMEKKLRKIRARTQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELL 870

  Fly  1046 NAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDE 1110
            ....:.:|:::.|:|.|.|||:||:|||.:||.|:.|||::|||||||||||:||.:||:|| ::
Human   871 METAQHLENQLTLLGATGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLL-NQ 934

  Fly  1111 LADVFIVDGNSVEEVE-------KQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQ 1168
            ...|:.::..:.|..|       ::|:||:|..|
Human   935 TDTVYTINTENQETCESILNCALEELKQFRELQK------------------------------- 968

  Fly  1169 TSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDE 1233
                                                 ||    ..|||....|:.....|..|..
Human   969 -------------------------------------PD----RKLFGFRLPSKTPSITSEAVVP 992

  Fly  1234 NTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGD 1298
            ..|  ||::|.:|......:||.|||::...|::|:|||.|||||:::|:|::.....:||:|||
Human   993 EAG--LVIDGKTLNAIFQGKLEKKFLELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGD 1055

  Fly  1299 GANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKN 1363
            ||||||||:||.||:|||||||:|||:|||::|.:|::|::||||||.|.|.|:.:.:.|:.|||
Human  1056 GANDVSMIQAADIGIGISGQEGMQAVMSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKN 1120

  Fly  1364 FAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGL 1428
            ..:.....||..|||||:.|:.|...:..:|||:||||.|..||.::|:|.:..|..|.||..|.
Human  1121 VCYVNLLFWYQFFCGFSSSTMIDYWQMIFFNLFFTSLPPLVFGVLDKDISAETLLALPELYKSGQ 1185

  Fly  1429 KSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQI 1493
            .||.:|:..|..|::...:.||:.|.|||..||      |..: |..|.|..:.||.:.......
Human  1186 NSECYNLSTFWISMVDAFYQSLICFFIPYLAYK------GSDI-DVFTFGTPINTISLTTILLHQ 1243

  Fly  1494 SLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVI------GGPY---VGSLTQAMKDLTFWVTMLI 1549
            ::....||:.:.|.:.||.:.||::...||...      ..||   .|.|:..    ||::...:
Human  1244 AMEMKTWTIFHGVVLLGSFLMYFLVSLLYNATCVICNSPTNPYWVMEGQLSNP----TFYLVCFL 1304

  Fly  1550 TVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQ 1614
            |.:..:.|    :::.|.:..:....:..|: :||.............|.|.|:........|..
Human  1305 TPVVALLP----RYFFLSLQGTCGKSLISKA-QKIDKLPPDKRNLEIQSWRSRQRPAPVPEVARP 1364

  Fly  1615 EGFGRLITSGKIMHKLPQDFAFPLGLGTKKT-----------QVLHNNL--------NSADGPNS 1660
                   |...:.....|||:    ..|.|:           .|||...        :|..| :|
Human  1365 -------THHPVSSITGQDFS----ASTPKSSNPPKRKHVEESVLHEQRCGTECMRDDSCSG-DS 1417

  Fly  1661 KGNNVTGHHMVNNNTNMRHNQNQ 1683
            .....:|.|::..|..|.:::.|
Human  1418 SAQLSSGEHLLGPNRIMAYSRGQ 1440

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	159/401 (40%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	220/604 (36%)
ATP10B	NP_079429.2	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	439/1332 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..541		10/50 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	640..687		6/46 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1346..1397		10/61 (16%)