Protein Alignment ATP8B and tat-3

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_499363.3
• Gene: tat-3 / 176498
• WormBaseID: WBGene00012360
• Length: 1411
• Species: Caenorhabditis elegans
• Alignment Length: 1472
• Identity: 454/1472 - (30%)
• Similarity: 703/1472 - (47%)
• Gaps: 266/1472 - (18%)

  Fly   199 NDKEFNAQF-----KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTP 258
            |.||...::     ||..|.|.|:|||:.||:|.||.||..|.||.||:.:::|.:|  |.:...
 Worm    88 NQKEPPPRYEQPNRKYCGNRISTTKYSVLTFIPKNLFEQLHRAANLYFIFIVILNMI--IGAFGK 150

  Fly   259 VTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKT-----LRNGKLVEAKWSEVQVGDVIR 318
            ..:.:|:..||.:||:|||::|.:|:.||.::|:...:.     .|..||   :|..:.|||.:.
 Worm   151 YISVLPIAFVLGITAIKDAFEDYRRYKSDQKINHSTCRVWDASQQRYRKL---EWQNILVGDFVH 212

  Fly   319 LDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHD-------SLWNF 376
            |.:::.:.||.|||.:|:.||:|::||..||||:|||.:|.:.   .:|..|:       |...|
 Worm   213 LSHDEIIPADILLLRSSDVNGVCYVETCNLDGESNLKQRQAIR---SMGKYHNANVPLEYSPAEF 274

  Fly   377 NGEIICERPNNLLNKFDGTL--IWRGQRFA-----LDNEKILLRGCVLRNTQWCYGVVVFAGVDT 434
            |..|.||:|...:.||:|.|  |..|...|     |..|.:||||||::||.:..|:|::||.||
 Worm   275 NYRIACEQPTTDVYKFEGRLEAIEGGPPLAREFTILAKENVLLRGCVVKNTDFVEGIVLYAGKDT 339

  Fly   435 KLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQL-YLPWEHIIP 498
            |.|.|:...::|.:.::::.|..|:..|..|:::|.:.|:...:|.......:.: :|.:.|  |
 Worm   340 KAMLNNNGPRYKRSSLEKMTNVDILWSVCTLLALCVIGAVLSGVWLRTFSTPYIVPFLVFIH--P 402

  Fly   499 KD-----------YIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYY 552
            ..           |.|:..:...   |:||.|||..::|||||||:|.|:..|.:.::.|..|||
 Worm   403 NSSYHNNNDSQYKYSPSYESWFS---FWSYIIVLQVMIPISLYVSIEFIKIFQVWFMSQDRNMYY 464

  Fly   553 PTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYG-----DVID------ 606
            ...:...:.|...:.||||||||:.||||||||:|.|.|.:||:||..||     |.:|
 Worm   465 DKVDKRLQCRALNITEELGQIQYVMSDKTGTLTENQMVFRRCSVNGNDYGGRPVVDAVDSSLELV 529

  Fly   607 ---LRTGELVEITEQQTIFQNSNTNN---RPSPLSGAIVAPPAAPPPI---ILVHKAEVHAKKTS 662
               ||:.:..|...|......:....   |||       ..||....:   :|...|::.....:
 Worm   530 ASTLRSDQPTEKKLQMAALAEAAAKTRRLRPS-------RDPALESQLASSVLKLGADIDDPVFA 587

  Fly   663 MVVTSS-GEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGG 726
            ..:|.: ....|:..:|..|:  ..|..|....|        .||.        .:|||...|
 Worm   588 FFLTMAICNTVVVNAKPHEDL--MDPDGDIVNSR--------FAPE--------EVSPRRGSS-- 632

  Fly   727 LSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIR 791
                       :..|||.. |...:...:.|.:...|.|..::...|               :|.
 Worm   633 -----------LEDGFKYL-ADVEEESPASTQASTPVMITEENDGFE---------------EIE 670

  Fly   792 FKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSA 856
            ..:.|...|....:::.|..:..|..:..:.|..|.:::..:..........||...| ||.|:.
 Worm   671 LIEFPEVKTDETQMTEKEETISAEVAAKKSGSDEKDNNYNGERKEGKGFGILHRPSIL-SVPFAK 734

  Fly   857 NPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAAR 921
            ....:|.||          ||.::.|.      :...|.:|..:..  .|.::||||.|||.|||
 Worm   735 LKGMKSPFR----------RSVDKRSS------SSTETAVAPPLHS--FYDSESPDELALVEAAR 781

  Fly   922 NFGFVFRTRTPNSITIEVMGQTE--EYELLNILDFNNVRKRMSVILRRGDSM---VLYCKGADNV 981
            .:|.....|..:.:.:.:...|.  :|::|:.|.|:..|||||||:|....:   ::..||||..
 Worm   782 EYGIRLLRRRFDDVIVYLRHSTSSVKYKVLHTLPFDADRKRMSVIIRESSGLKRIIVLTKGADAT 846

  Fly   982 IYDRL------HGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDS 1040
            :...|      ....|::..::|:||.::|.||||||.|:.:..||:.|..|:.:.:||.|.|..
 Worm   847 VIPVLSEAFSTSARGEEVIFKSQEHLTQYAKEGLRTLCLSMKIWTEEEYQGWKEKHEEAELDMMD 911

  Fly  1041 REQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQ 1105
            :|..|.......|.:::|:|||||||:||||||:.|.:|:.|||::|||||||.|||:||.||.:
 Worm   912 KETMLAESTLRAEQDLELLGVTAIEDRLQDGVPECIHSLREAGIRVWVLTGDKIETAVNIAYSSR 976

  Fly  1106 LLTDELADVFIVDGNSVEEVEKQLRQ-FKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQT 1169
            |.:..: |:..:..|.|..|...|.: .|...:.|                            :.
 Worm   977 LFSPSM-DLLNIGANGVRAVSDLLTEHLKRIARAY----------------------------EV 1012

  Fly  1170 SAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDEN 1234
            ||                                   |:|:
 Worm  1013 SA-----------------------------------DAAD------------------------ 1018

  Fly  1235 TGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDG 1299
             .|.||:|..::.:||.|....:|:.:...|::|:|||.||||||.:|.|.|.......||||||
 Worm  1019 -SFGLVLNASTMSYCLDPHNLERFVKLLRGCRSVLCCRATPLQKAQLVNLAKNHLKGKVLAIGDG 1082

  Fly  1300 ANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNF 1364
            |||||||:.|.:|:|:|||||:|||:|||:::|:||:|..||||||.|:|||:.:.:.||||||.
 Worm  1083 ANDVSMIQGADVGIGLSGQEGMQAVMSSDFAMARFRFLSNLLLVHGHWNYYRLAQTILYFFYKNA 1147

  Fly  1365 AFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLK 1429
            .......||.:|.|||||...||:::.||||.:||:|.|..|..:||.|.:..|:.||||..|..
 Worm  1148 MLVFVIFWYQIFNGFSAQVPIDPVYLMVYNLIFTSVPPLLFGCLDQDASAELLLDCPRLYEQGRL 1212

  Fly  1430 SELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQIS 1494
            .:.:....|..::|...:.|||:|.|.|..|:   .:|    .|..|.|.::.|.||:.||..::
 Worm  1213 GKRYRWYSFWINMLDAVWQSLVVFFICYFTYR---GSN----VDMWTFGHLLVTQLIIVNTFHLA 1270

  Fly  1495 LYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGG----------PYVGSLTQAMKDLTFWVTMLI 1549
            |:..|||.....:::.|::.:|:....||..:..          |.:.|| ::...|.||:.::|
 Worm  1271 LFVQYWTWPMFWSMFLSVLLFFICALLYNGFVTANWTWTNVKDPPSMVSL-KSFSSLEFWMALII 1334

  Fly  1550 TVMALVAPVLAYKFYLLDVHPSLSDKIRQKS----LKKIHSR 1587
            :|:..:.|.......:..|.||.:.:.|..:    .||..||
 Worm  1335 SVVLCLTPRYVLTTVVNTVSPSTTLRTRLGAEDGFKKKTESR 1376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	153/421 (36%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	204/582 (35%)
tat-3	NP_499363.3	P-type_ATPase_APLT_Dnf-like	105..1239	CDD:319770	412/1308 (31%)