Protein Alignment ATP8B and tat-4

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001379745.1
• Gene: tat-4 / 174031
• WormBaseID: WBGene00020784
• Length: 1212
• Species: Caenorhabditis elegans
• Alignment Length: 1456
• Identity: 411/1456 - (28%)
• Similarity: 636/1456 - (43%)
• Gaps: 338/1456 - (23%)

  Fly   166 SESKSVP---SLRRLSQIRRRRSSYYFSENERRIRAND------KEFNAQFKYHNNYIKTSKYSL 221
            |.||.||   .|.....|.|.||:.  ....|.||.|.      .|.|....:.:|.|.|:||:.
 Worm    13 SSSKWVPPSAPLHNPISIFRGRSNR--ETGSRVIRPNHLFESPRYELNNYRDFTDNRISTTKYTF 75

  Fly   222 FTFLPFNLLEQFQ-RLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHI 285
            :.|:|.|:..|.. :.||.||:.:.:|..:|...:.|.....||:..||..|.:||..:|.:|:.
 Worm    76 WNFIPLNIWHQVSTKYANLYFIFIAILNWVPFFDAYTRYVGLIPICFVLGTTLIKDGIEDYRRYK 140

  Fly   286 SDSQVNNRKSKTLRNGKLV--EAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAEL 348
            .|:|:|.:........:..  :.:|..:.|||.:.:.|||.|.||.:||.:|..:|.|:|||..|
 Worm   141 FDNQINKKTCHVWDRDRCAFRKTEWRYILVGDFVHISNNQDVPADIILLRSSSESGTCYIETCNL 205

  Fly   349 DGETNLKAKQCLTETIELGDRHDSLW---NFNGEIICERPNNLLNKFDGTLIWR-GQRFALDNEK 409
            ||||:||.:....:.|:. .:.||.:   :|.|.:.||:|:..:......:.:. ||...:..|.
 Worm   206 DGETSLKQRMVPAKVIDY-SKKDSTFKPPDFTGVVTCEKPDKSIYTIRAKVEFEPGQSDVIIKEN 269

  Fly   410 ILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAI 474
            :||||..::||.:..|:||:||.|||:|||:|:...|::|:::|.|..||...:.|:.:....||
 Worm   270 MLLRGSRIKNTTFVEGIVVYAGHDTKVMQNNGRAPHKTSGIEKLTNKFIIACFIMLLLMVLYGAI 334

  Fly   475 GCAIWEGLIGQHFQLYLPWEHIIPKDYI------PTGATVIGLLVFFSYAIVLNTVVPISLYVSV 533
            ..|:|   :|||     |.:..||  :|      |.....||:..||   |....:||||||::|
 Worm   335 TSAVW---VGQH-----PVDEQIP--FILSNTPRPFIEGFIGIGAFF---INYQLLVPISLYITV 386

  Fly   534 EVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSING 598
            |:|:.:|.:.|:.|.::|...::.....|:.::.||||.:.::.||||||||:|:|.|..|:.:.
 Worm   387 EIIKALQIYFISNDIQLYDQKSDRAIDCRSLSIPEELGTVTHVLSDKTGTLTENMMIFRNCAFDE 451

  Fly   599 RSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAK-KTS 662
            ..||                    .|.:.:|...|                 |...|::.: .||
 Worm   452 TDYG--------------------SNGSQSNPDKP-----------------VKSDELYQRILTS 479

  Fly   663 M--VVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSG 725
            |  .|.....|.:|.:  .|.:....|..|..|
 Worm   480 MQNPVQKHFFANILLN--NSVVVNHIPHTDVLE-------------------------------- 510

  Fly   726 GLSPPVGNEERRISGGFKRSGAGCM-----QRQLSRTSSCDKVKILHD--SQQTETHNMHHSSHN 783
                 :||    ..||....|..|.     ::...:.::..|..:..|  |:..|......|...
 Worm   511 -----LGN----FDGGVYNIGNSCFYDVTEEKYKQKLAAIGKGGVDDDDVSRPDELGLPTTSIQF 566

  Fly   784 RKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS---SSPHR 845
            ..||..|..:..||.:.   ........|.|.|..||.:       :|..:..:::|   |:..|
 Worm   567 DDRLTVIVEEDTPSDSP---APDASPRDLPETPTPTSPI-------YRPLSSLSSFSRKLSTVVR 621

  Fly   846 VHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQS 910
            ...|:.:         ||        :..||.         ||::.....|.       .|:|:|
 Worm   622 RSILRPI---------SD--------IIPVRK---------RLISFKQQAMN-------PYEAES 653

  Fly   911 PDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEE-YELLNILDFNNVRKRMSVILRRGDSMVLY 974
            |||.||:..|..:.:|...|...|:||....:.|: ||:|..|.|:..|||||||:......::|
 Worm   654 PDELALIEGAALYDYVLLERAATSVTISTPEKAEKRYEILLTLPFDATRKRMSVIVNSQKGPLMY 718

  Fly   975 CKGADNVIYDRLHGGQ------EDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYND----WRS 1029
            |||||:.|..||....      :|||    |||:.:|.:|||||..|.:.::::.:.|    :|.
 Worm   719 CKGADSAIISRLSSDSLESKRVQDLK----DHLDNYAKKGLRTLCFAMKYISKEDFEDFLDSYRF 779

  Fly  1030 RQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQ 1094
            ..::|.   ..||:.|:...:|:|:.::|.|||.|||:||||||.::..|::|||::|||||||.
 Worm   780 LMEDAT---SEREKMLSEKADELETNLKLSGVTGIEDRLQDGVPDTLRALRDAGIQVWVLTGDKL 841

  Fly  1095 ETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNM 1159
            |||.||..|..|                                   |.|              .
 Worm   842 ETAQNIATSSGL-----------------------------------FHP--------------Q 857

  Fly  1160 DPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDG 1224
            ..|.|..|:|.|                                              |:.||..
 Worm   858 RSLKVIETETDA----------------------------------------------EEASESA 876

  Fly  1225 GTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAK 1289
            |...|:.......|...|.|             .::...:.|.|:|.|:||.:||.:|..:|:..
 Worm   877 GLNIIMSPAAIRLAQDGNAH-------------LMEALKKAKTVLCYRMTPSEKATIVNTVKKRI 928

  Fly  1290 NAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCK 1354
            ....||||||||||.||:|||:|:||:|:|||||.::.|::||:|::|.|||||||.|||||:..
 Worm   929 KGNVLAIGDGANDVPMIQAAHVGIGIAGKEGLQAAMACDFAIARFKFLSRLLLVHGHWSYYRLAN 993

  Fly  1355 FLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLE 1419
            ...||.|||........:|..:.|.|...:.||::..:|.:.:||:..:.:||.:||..|:..:.
 Worm   994 TFLYFLYKNANAVFIIFYYQFYNGASGTNIVDPIWGVIYPIIFTSVQPVVVGVLDQDYDDQTLMN 1058

  Fly  1420 FPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMT-----LGA 1479
            .|.||..|.:::|:..:.|...|:.|.:.:.|::.:.|            :..|:.|     :|.
 Worm  1059 KPELYVIGRENQLYTWKHFFRDVIDGIYQAAVIYYVAY------------LTLDNSTSSLWEMGF 1111

  Fly  1480 VVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNY-------------VIGGPYV 1531
            .:||..|:.|:..::|...||    |   | .||..|.....:|:             ::..|.|
 Worm  1112 YIATSSILVNSGHLALQVRYW----H---W-QLVALFSFFILFNFAFFFAECLTAAAAMVPDPPV 1168

  Fly  1532 GSLTQAMKDLTFWVTMLITVMALVAP 1557
            .....||.|..||....|||:..:.|
 Worm  1169 WMPIHAMGDPRFWYYQFITVIVALCP 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	21/71 (30%)
		Cation_ATPase	891..985	CDD:289987	35/94 (37%)
		HAD_like	<1261..1324	CDD:304363	33/62 (53%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	72/252 (29%)
tat-4	NP_001379745.1	P-type_ATPase_APLT_Dnf-like	65..1095	CDD:319770	367/1281 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.930