Protein Alignment ATP8B and tat-5

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_001021457.1
• Gene: tat-5 / 172748
• WormBaseID: WBGene00009498
• Length: 1074
• Species: Caenorhabditis elegans
• Alignment Length: 1423
• Identity: 350/1423 - (24%)
• Similarity: 560/1423 - (39%)
• Gaps: 459/1423 - (32%)

  Fly   169 KSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQF 233
            :|:.|.||:...|..|..|           .....:|...:..|.:...||::|:|:|..|.:||
 Worm    74 RSLFSRRRVLHSRTVRVGY-----------GPVGHDANVTFTPNTVCNQKYNIFSFVPIVLFQQF 127

  Fly   234 QRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRK-SKT 297
            :...|.|||.:...|.||||....|:|...||..|||:|.:::|:||..|::.|..:|:.| .|.
 Worm   128 KFFLNLYFLLMACSQFIPAIQIGAPITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEKYEKL 192

  Fly   298 LRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTE 362
            .|:|..:|.:.::::|||||.:..::.|.||.:||.|::.:|.|||.|.:|||||:.|.:..:..
 Worm   193 TRDGTRIEIRSADIEVGDVIIMHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRIPVPH 257

  Fly   363 TIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQW----- 422
            |..|.:..| :...|.|:..|:|...::.|.|||      ...|::.:......:.|..|
 Worm   258 TQHLPNEAD-IMELNCEVYAEKPQKDIHAFVGTL------KITDDDNVQDGSLNVENVLWANTVV 315

  Fly   423 ----CYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FIIIGIVLFLVSICALFAIGCAIWE 480
                ..|:||:.|.:|:.:.|:...:.|...:|..:|   .::...||.|.|:....       :
 Worm   316 ASGTAVGIVVYTGRETRSVMNTTLPESKVGLLDLEVNNLTKLLFCFVLVLSSVMVAM-------K 373

  Fly   481 GLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLIN 545
            ||....:: ||                 :..::.|||      ::||||.|::::.:...|:.|.
 Worm   374 GLDNLWYR-YL-----------------MRFILLFSY------IIPISLRVNLDMAKLFYSWQIG 414

  Fly   546 WDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTG 610
            .|:  :.|.|    ..|::|:.||||:|.::.||||||||:|.|.|.|           |.|.|
 Worm   415 RDK--HIPET----VIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKK-----------IHLGT- 461

  Fly   611 ELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLP 675
                                                                 |..||
 Worm   462 -----------------------------------------------------VAFSS------- 466

  Fly   676 DRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISG 740
                          ||.|:..  :|||        .|.||||:
 Worm   467 --------------DAFEEVG--QHVR--------SAYAGRLA---------------------- 485

  Fly   741 GFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVI 805
                                                                             
 Worm   486 ----------------------------------------------------------------- 485

  Fly   806 SQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRT 870
                                ||                         .|||.
 Worm   486 --------------------KH-------------------------SFSAK------------- 492

  Fly   871 LLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSI 935
            |.:||.:           :||||.|.....:|::.|||.||||.|||......|....:|..:::
 Worm   493 LQNAVEA-----------IALCHNVTPIFENGEISYQAASPDEVALVKWTETVGVRLASRDLHAM 546

  Fly   936 TIEVM---GQT--EEYELLNILDFNNVRKRMSVILR--RGDSMVLYCKGADNVIYDRLHGGQEDL 993
            ::.|.   |||  :::::|.:..|.:..|||.:|::  ..|.:.|..||||.|:     .|....
 Worm   547 SLSVQLPNGQTLMKQFQILYVFPFTSETKRMGIIVKDETTDEVTLLMKGADTVM-----SGMVQY 606

  Fly   994 KARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKL-NAIYEEIESEMQ 1057
            .....:..:..|.||||||.:|.:.|::.....:......|.:|:..|.|.: |.:...:|.::|
 Worm   607 NDWLDEECSNMAREGLRTLVVARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRMLERDLQ 671

  Fly  1058 LVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSV 1122
            |:.:|.:||:|||.|..|:..|:|||||||:|||||.||||.|..|..|.:  .:|...|.||
 Worm   672 LLCLTGVEDRLQDQVTTSLELLRNAGIKIWMLTGDKLETAICIAKSSGLFS--RSDNIHVFGN-- 732

  Fly  1123 EEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPA 1187
                           ::|
 Worm   733 ---------------VHN----------------------------------------------- 735

  Fly  1188 ISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSP 1252
                  |.|..|          |.|||                 ...|..|||:.|.:|..||.
 Worm   736 ------RTDAHN----------ELNNL-----------------RRKTDVALVMPGSALNVCLQ- 766

  Fly  1253 ELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTL-AIGDGANDVSMIKAAHIGVGIS 1316
            ..|.:..::...|.||:|||.:|.|||.:|:|:::.:..:.: |||||.||||||:|||.|:||.
 Worm   767 YYEAEVAELVCACTAVVCCRCSPEQKAQIVQLLRKYRAPLRVAAIGDGGNDVSMIQAAHAGIGID 831

  Fly  1317 GQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSA 1381
            ..||.||.|::|:||.||.::.||||||||:.|.|.|...::..::....:.....:|....|::
 Worm   832 ANEGKQASLAADFSITQFSHVCRLLLVHGRFCYKRSCALSQFVMHRGLIISTMQAIFSCVFYFAS 896

  Fly  1382 QTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGA 1446
            .:::..:.:..|:..||.|||.:| |.::||:..|:|.:|.||....|....:.:.|...||...
 Worm   897 VSLYQGVLMVAYSTCYTMLPVFSL-VVDRDVTATNALTYPELYKELGKGRSLSYKTFCIWVLISL 960

  Fly  1447 FTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGS 1511
            :...|   |.||...  |....|:....::..|::.|.||:   ..::::|.:|.::....:  |
 Worm   961 YQGAV---IMYGALL--VFDADFIHVVSISFSALIVTELIM---VAMTVHTWHWAMLLAQAL--S 1015

  Fly  1512 LVWYFV----LDYFYN--YVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKF 1563
            |..|.:    .|.:::  :|:...::...|.        :|.:..:...:...|..||
 Worm  1016 LGLYMISLILFDQYFDRQFVLSWVFISKTTA--------ITAVSCLPLYIVKALRRKF 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	122/403 (30%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	174/579 (30%)
tat-5	NP_001021457.1	P-type_ATPase_APLT_Neo1-like	105..995	CDD:319841	328/1296 (25%)
		Cation_ATPase	501..600	CDD:463817	34/98 (35%)