DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP8B3

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:XP_006722717.1 Gene:ATP8B3 / 148229 HGNCID:13535 Length:1310 Species:Homo sapiens


Alignment Length:1614 Identity:523/1614 - (32%)
Similarity:780/1614 - (48%) Gaps:431/1614 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 DEDVKQPERRNSDLEGSPRACLAQPEGMNIGSSTQTIATPLMIGDSFYSLAPGGGNP------PP 148
            |.||.|        |||      .|.|:..|   :|:....| |||     ||.|.|      .|
Human    30 DSDVTQ--------EGS------GPAGIRGG---ETVIRAGM-GDS-----PGRGAPERRHKAQP 71

  Fly   149 NKSDDQELYKQRDPSVTSESKSVPSL--RRLSQIRRRRSSYYFSENERRIRANDKEFNAQF---- 207
            .::...| ::...|:      |:.||  |...|...|.|::.:     :::||::.:|.||    
Human    72 GRARKYE-WRPEGPT------SMGSLGQREDLQDEDRNSAFTW-----KVQANNRAYNGQFKEKV 124

  Fly   208 -------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPL 265
                   ||..|.|:|:||:.::|||.||.|||.|::|.:||.:::||.||.||:|...:.:.|:
Human   125 ILCWQRKKYKTNVIRTAKYNFYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPM 189

  Fly   266 IGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTL 330
            :.:|.:.|.:|..||:.||.||..:|||..:.|......:.||.::.||||:.|..:..|.||.|
Human   190 VCLLFIRATRDLVDDMGRHKSDRAINNRPCQILMGKSFKQKKWQDLCVGDVVCLRKDNIVPADML 254

  Fly   331 LLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGT 395
            ||:::||:.||::||.::|||||||.:|.|..|.:.......:.:|.|.:.||.||:.::.|.|.
Human   255 LLASTEPSSLCYVETVDIDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVGC 319

  Fly   396 LIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIG 460
            |.|..::::||...:|||||.:|||..|||:|::||.|||:|:|.||...|.|.:|.|:|.:::.
Human   320 LEWNDKKYSLDIGNLLLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVV 384

  Fly   461 IVLFLVSICALFAIGCAIWEGLIGQHFQ---LYLPWEHIIPKDYIPTGATVI--GLLVFFSYAIV 520
            |.:.:|.:|.:.|.|.    |...:.|:   .||...|         |::|.  ...||:|:.|:
Human   385 IFISVVLVCLVLAFGF----GFSVKEFKDHHYYLSGVH---------GSSVAAESFFVFWSFLIL 436

  Fly   521 LNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLT 585
            |:..:|:|:::..|.|....|..|:||.:|||...:..||||:|:||:.|||::|||||||||||
Human   437 LSVTIPMSMFILSEFIYLGNSVFIDWDVQMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLT 501

  Fly   586 QNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIIL 650
            |||:|||||.|:||.||                    .:|....||                   
Human   502 QNILTFNKCCISGRVYG--------------------PDSEATTRP------------------- 527

  Fly   651 VHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAG 715
                                                      ::.|.|                 
Human   528 ------------------------------------------KENPYL----------------- 533

  Fly   716 RLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHS 780
                                                                             
Human   534 ----------------------------------------------------------------- 533

  Fly   781 SHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHR 845
                                                                      |      
Human   534 ----------------------------------------------------------W------ 534

  Fly   846 VHALQSVDFSANPHHESDFRWYDRTLLDAVRSD-EEHSHVFFRLLALCHTVMA-----ETVDGKL 904
                       |...:....:::..||..||:: :|....|:||||:|||||.     |..| :|
Human   535 -----------NKFADGKLLFHNAALLHLVRTNGDEAVREFWRLLAICHTVMVRESPRERPD-QL 587

  Fly   905 EYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            .|||.||||.|||:||||||:||.:||.:::||..:|:...|::|.|:|||:.||||||::|:.:
Human   588 LYQAASPDEGALVTAARNFGYVFLSRTQDTVTIMELGEERVYQVLAIMDFNSTRKRMSVLVRKPE 652

  Fly   970 SMV-LYCKGADNVIYDRLH--GGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQ 1031
            ..: ||.||||.||::|||  |..|   ..|::.|..||.|.||||.||.|.:.|..|.||:.|.
Human   653 GAICLYTKGADTVIFERLHRRGAME---FATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRH 714

  Fly  1032 QEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQET 1096
            |||:|.:.:|.|.|..:|.|:|.:::|:|.|||||:||||||::|..|:.:.|||||||||||||
Human   715 QEASLLLQNRAQALQQVYNEMEQDLRLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQET 779

  Fly  1097 AINIGYSCQLLTDELADVFIVDGNSVEEV-------------EKQLRQFKESIKIYNRFRPGGFD 1148
            |:|||::|:||::   ::.|::...:..:             .:.|.|.|.::.|...|      
Human   780 AVNIGFACELLSE---NMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDF------ 835

  Fly  1149 PFDRLNSDSNMDPLSVTM-TQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECN 1212
                      :|.|.|:: .:..|..|..|:...             |.|..:..:   |.....
Human   836 ----------LDKLLVSLRKEPRALAQNVNMDEA-------------WQELGQSRR---DFLYAR 874

  Fly  1213 NL------FG---------DEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIA 1262
            .|      ||         |.:...    :|.|:.|..                      |:|:|
Human   875 RLSLLCRRFGLPLAAPPAQDSRARR----SSEVLQERA----------------------FVDLA 913

  Fly  1263 SQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSS 1327
            |:|:|||||||||.||||:|.|:|:....|||||||||||::|||.|.:|||::||||:|||.:|
Human   914 SKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNS 978

  Fly  1328 DYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISV 1392
            |:.:.||.:|:|||||||||||.|:||||||||||:.|..:...|::.:.||:.|.:::..|:::
Human   979 DFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLAL 1043

  Fly  1393 YNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPY 1457
            :||.|::||||.:|:||||||.:.|||.|.||..|.|.||||...|:.::.||..||||.|.:..
Human  1044 FNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNYWVFVQAIAHGVTTSLVNFFMTL 1108

  Fly  1458 GVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVL---- 1518
            .:.:|......|  |||.:...|||...::..|.::.|...|||.:...||..||.:|.::    
Human  1109 WISRDTAGPASF--SDHQSFAVVVALSCLLSITMEVILIIKYWTALCVATILLSLGFYAIMTTTT 1171

  Fly  1519 DYFYNYVIGG---PYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKS 1580
            ..|:.:.:..   |::.:....|...:..:.:|::|.....||||.:.    :.|:|.: :|.|.
Human  1172 QSFWLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRV----IFPALKE-LRAKE 1231

  Fly  1581 LKKIHSRASSDV---RRTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLP 1631
             :|:....|.::   .......|..|:.||.|||:|:||:..|||.|.|:.:.|
Human  1232 -EKVEEGPSEEIFTMEPLPHVHRESRARRSSYAFSHREGYANLITQGTILRRGP 1284

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 31/75 (41%)
Cation_ATPase 891..985 CDD:289987 52/99 (53%)
HAD_like <1261..1324 CDD:304363 42/62 (68%)
PhoLip_ATPase_C 1324..1571 CDD:292829 95/253 (38%)
ATP8B3XP_006722717.1 PhoLip_ATPase_N 108..184 CDD:292826 31/75 (41%)
ATPase-Plipid 133..1220 CDD:273734 466/1408 (33%)
Cation_ATPase <593..669 CDD:289987 41/75 (55%)
HAD_like <931..975 CDD:304363 27/43 (63%)
PhoLip_ATPase_C 975..1220 CDD:292829 95/250 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 1 1.100 - - O PTHR24092
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
87.830

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