DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and Atp10a

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_033858.2	Gene:	Atp10a / 11982	MGIID:	1330809	Length:	1508	Species:	Mus musculus

Alignment Length:	1594	Identity:	504/1594 - (31%)
Similarity:	767/1594 - (48%)	Gaps:	317/1594 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 NNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVK 275
            :|.:||:||:|.:|||.||.|||.||||.||:.:.:|..:||:::..|.....|::.:|.:||:|
Mouse    65 DNRLKTTKYTLLSFLPKNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIK 129

  Fly   276 DAYDDIQRHISDSQVN-------NRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLS 333
            |.::|..||.||.::|       :|:.|     |.|...|.|::|||.:||..|:.:.||.||||
Mouse   130 DLWEDYSRHRSDHEINHLGCLVFSREEK-----KYVNRYWKEIRVGDFVRLCCNEIIPADILLLS 189

  Fly   334 TSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIW 398
            :|:|:|||.||||.||||||||.:|.:....||....:.| .|...|.||:|||.|::|.|.::.
Mouse   190 SSDPDGLCHIETANLDGETNLKRRQVVRGFSELVSEFNPL-TFTSVIECEKPNNDLSRFRGYIMH 253

  Fly   399 -RGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIV 462
             .|::..|..|.:|||||.:|||:...|:|::||.:||.:.|:...::|.:.::|.:|..::..|
Mouse   254 SNGEKAGLHKENLLLRGCTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMNCDVLWCV 318

  Fly   463 LFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPK----DYIPTGATVIGLLVFFSYAIVLNT 523
            |.||.|....|:|..:|.....:...|:     .:|:    ...|..|.|..   ||:..|||..
Mouse   319 LLLVCISLFSAVGHGLWVRRYQEKKALF-----DVPESDGSSLSPATAAVYS---FFTMIIVLQV 375

  Fly   524 VVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNI 588
            ::|||||||:|:::..|.:.||.|.|:|...|::..:.|...:.|:||||:|||||||||||:|.
Mouse   376 LIPISLYVSIEIVKVCQVYFINQDIELYDEETDSQLQCRALNITEDLGQIKYIFSDKTGTLTENK 440

  Fly   589 MTFNKCSINGRSYG-DVIDLRTGELVEITEQQ--------TIFQNSNTNNRPSPLSGAIVAPPAA 644
            |.|.:|:::|..|. |....|.....|...::        ||....:|.:..|
Mouse   441 MVFRRCTVSGIEYSHDANAQRLARYQEADSEEEEVVSKVGTISHRGSTGSHQS------------ 493

  Fly   645 PPPIILVHKAE-----------VHAKKTSMV-----VTSSGEAQVLPDRPRSDIERSAPPMDASE 693
               |.:.||.:           ..||:.||:     .:|..|..:.||          |.:
Mouse   494 ---IWMTHKTQSIKSHRRTGSRAEAKRASMLSKHTAFSSPMEKDITPD----------PKL---- 541

  Fly   694 KRPGLKHV----RYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQL 754
                |:.|    |:.|.:|.|:.....|||.|                 |..|....|
Mouse   542 ----LEKVSECDRFLAIARHQEHPLAHLSPEL-----------------SDVFDFFIA------- 578

  Fly   755 SRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFK-KAPSTATLGVVISQLEHHLDEEPQS 818
              .:.|:.|.:....|.             ::.|::||: |:|.......:.......|.....|
Mouse   579 --LTICNTVVVTSPDQP-------------RQKVRVRFELKSPVKTIEDFLRRFTPSRLASGCSS 628

  Fly   819 TSTLSTTKHHHHRSKAFATNWSSSP----------HRVHALQSVDFSANPHHESDFRWYDRTLLD 873
            ...|||:|..|....||..:.|...          ....::.|..:::....|..  |......|
Mouse   629 IGNLSTSKSSHKSGSAFLPSLSQDSMLLGLEEKLGQTAPSIASNGYASQAGQEES--WASECTTD 691

  Fly   874 AVRSDEEHSHVFFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIE 938
                            ..|.....|..:|:|.|:|:||||||||.|||.:......|..:.:::|
Mouse   692 ----------------QKCPGEQREQQEGELRYEAESPDEAALVYAARAYNCALVDRLHDQVSVE 740

  Fly   939 V--MGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIYDRL-----------HG 988
            :  :|:. .:|||:.|.|:::||||||::|.  .|.:.:|.||||:|:.|.|           |
Mouse   741 LPHLGRL-TFELLHTLGFDSIRKRMSVVIRHPLTDEINVYTKGADSVVMDLLLPCSSDDARGRH- 803

  Fly   989 GQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIE 1053
             |:.::::||::||.:|.||||||.:|:|.|:::.|..|.....||..|::|||:.|......:|
Mouse   804 -QKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQSHIEAEASVESREELLFQSAVRLE 867

  Fly  1054 SEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVD 1118
            :.:.|:|.|.|||:||:|||::||.|:.||::|||||||||||||||.|:|:|| |...:|..::
Mouse   868 TNLHLLGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQETAINIAYACKLL-DHGEEVITLN 931

  Fly  1119 GNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRL-NSDSNM------DPLSVTMTQTSAFMQET 1176
            .:|.|.....|.|....::..|        |...| ||:||:      :|:|.:          |
Mouse   932 ADSQEACAALLDQCLSYVQSRN--------PRSTLQNSESNLSVGFSFNPVSTS----------T 978

  Fly  1177 NLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVV 1241
            :..|:|                                                       :||:
Mouse   979 DASPSP-------------------------------------------------------SLVI 988

  Fly  1242 NGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMI 1306
            :|.||.:.|...||:|||.:|.||::|:|||.|||||::||:|::....|:||||||||||||||
Mouse   989 DGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQKSMVVKLVRSKLKAMTLAIGDGANDVSMI 1053

  Fly  1307 KAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHC 1371
            :.|.:|||||||||:|||::||:::.:||||||||:|||.|.|.|:...:.||||||..|.....
Mouse  1054 QVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWCYSRLANMVLYFFYKNTMFVGLLF 1118

  Fly  1372 WYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIR 1436
            |:..:|||||..:.|..::..:||.::|||.|..||.::||.....|..|:||..|...|.:..|
Mouse  1119 WFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKDVPADMLLREPQLYKSGQNMEEYRPR 1183

  Fly  1437 EFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWT 1501
            .|..:::..||.|||.|.|||..|.|.       ..|..|.|..|..|.:......:.:.|..||
Mouse  1184 AFWLNMVDAAFQSLVCFFIPYLAYYDS-------DVDVFTWGTPVTAIALFTFLLHLGIETKTWT 1241

  Fly  1502 VVNHVTIWGSLVWYFVLDYFYN------YVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLA 1560
            .:|.:....|...:|.:...||      |....|| .::...:.|..|::|.||..:|.:.|.|.
Mouse  1242 WLNWLACGFSTFLFFSVALIYNTSCATCYPPSNPY-WTMQTLLGDPLFYLTCLIAPIAALLPRLF 1305

  Fly  1561 YKFYLLDVHPS---LSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQEGFGRLIT 1622
            :|.....:.|:   |..::.:|.|.|.     ||.:.|.:  :|:....|....:.::..|...|
Mouse  1306 FKALQGSLFPTQLQLGRQLAKKPLNKF-----SDPKETFA--QGQPPGHSETELSERKTMGPFET 1363

  Fly  1623 SGKIMHKLPQDFAFPLGLGTKKTQVLHNNLNSADGPNSKGNNVTGHHMVNNNTNMRHNQNQNHSS 1687
                   ||:|.|   ...::.||.|..:..::..|::          |:.|..:|.|...
Mouse  1364 -------LPRDCA---SQASQFTQQLTCSPEASGEPSA----------VDTNMPLRENTLL---- 1404

  Fly  1688 MADITADGRGNGGDDGRGSGGSDDMSPRAPCQDL 1721
                          :|.||..|....||....::
Mouse  1405 --------------EGLGSQASGSSMPRGAISEV 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	24/48 (50%)
		Cation_ATPase	891..985	CDD:289987	39/97 (40%)
		HAD_like	<1261..1324	CDD:304363	41/62 (66%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	85/252 (34%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	444/1318 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..705		5/42 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1354		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1436		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1481..1508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.830