Protein Alignment ATP8B and Atp9a

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: NP_056546.2
• Gene: Atp9a / 11981
• MGIID: 1330826
• Length: 1047
• Species: Mus musculus
• Alignment Length: 1515
• Identity: 355/1515 - (23%)
• Similarity: 556/1515 - (36%)
• Gaps: 536/1515 - (35%)

  Fly    95 QPERRNSDLEGSPRACLAQPEGMNIGSSTQTIATPLMIGDSFYSLAPGGGNPPPNKSDDQELYKQ 159
            ||.|....::..|||                       |...:....|||.|.|.
Mouse     8 QPVRHKKRVDSRPRA-----------------------GCCEWLRCCGGGEPRPR---------- 39

  Fly   160 RDPSVTSESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTF 224
                                      :.:....|:|.:          :|..|.|...||:.|||
Mouse    40 --------------------------TVWLGHPEKRDQ----------RYPRNVINNQKYNFFTF 68

  Fly   225 LPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQ 289
            ||..|..||:...|||||.|...|.:|.:......|..:||..||.:|.:::|.::|:.::.|.:
Mouse    69 LPGVLFSQFRYFFNFYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTIIREAVEEIRCYVRDKE 133

  Fly   290 VNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNL 354
            :|::....|.:...|:.|.|.:||||:|.::.||.|.||.:.|.|||.||.||:.|.:|||||:.
Mouse   134 MNSQVYSRLTSRGTVKVKSSNIQVGDLILVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDW 198

  Fly   355 KAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRN 419
            |.:..:..|..|....| |......:..|.||..::.|.||....      |::..:.....:.|
Mouse   199 KLRLPVACTQRLPTAAD-LLQIRSYVYAEEPNIDIHNFLGTFTRE------DSDPPISESLSIEN 256

  Fly   420 TQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVD---RLLNFIIIG--IVLFLVSICA 470
            |.|.         .|||::.|.:.:.:.|:...:.|....|   ..|..|:.|  :|:.||.:..
Mouse   257 TLWAGTVIASGTVVGVVLYTGRELRSVMNTSDPRSKIGLFDLEVNCLTKILFGALVVVSLVMVAL 321

  Fly   471 LFAIGCAIWEGLIGQHF--QLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSV 533
                          |||  :.||               .:|..|:.||      .::||||.|::
Mouse   322 --------------QHFAGRWYL---------------QIIRFLLLFS------NIIPISLRVNL 351

  Fly   534 EVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSING 598
            ::.:.|.|::|..|.::  |.|    ..|::|:.|:||:|.|:.:|||||||||.|.|.:..:..
Mouse   352 DMGKIVYSWVIRRDSKI--PGT----VVRSSTIPEQLGRISYLLTDKTGTLTQNEMVFKRLHLGT 410

  Fly   599 RSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTS 662
            .:|| |.:|.....:..|..||
Mouse   411 VAYGLDSMDEVQSHIFSIYTQQ------------------------------------------- 432

  Fly   663 MVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGL 727
                                                          |||
Mouse   433 ----------------------------------------------SQD---------------- 435

  Fly   728 SPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRF 792
             ||.
Mouse   436 -PPA------------------------------------------------------------- 438

  Fly   793 KKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSAN 857
            :|.|:..|                :...|:|:                    |||
Mouse   439 QKGPTVTT----------------KVRRTMSS--------------------RVH---------- 457

  Fly   858 PHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTV-----------MAET----VDGKLEYQ 907
                           :||::           :||||.|           .||.    .|....||
Mouse   458 ---------------EAVKA-----------IALCHNVTPVYESNGVTDQAEAEKQFEDSCRVYQ 496

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG-QTEEYELLNILDFNNVRKRMSVILRRGDS- 970
            |.||||.|||....:.|.....|..:|:.:...| |.....:|.:..|....|||.:|:|...:
Mouse   497 ASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQVLNLTILQVFPFTYESKRMGIIVRDESTG 561

  Fly   971 -MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEA 1034
             :..|.||||.|:     .|........::.....|.||||.|.:|::.|||:.|.|:.:|..:|
Mouse   562 EITFYMKGADVVM-----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYVQA 621

  Fly  1035 ALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAIN 1099
            .||:..|..|:..:.|.:|.||:|:.:|.:||:||..|..::..|:|||||:|:|||||.|||..
Mouse   622 KLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETATC 686

  Fly  1100 IGYSCQLLT-DELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            ...:..|:| ::...||.:..|. .|...:|..|:.
Mouse   687 TAKNAHLVTRNQDIHVFRLVTNR-GEAHLELNAFRR----------------------------- 721

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTAS 1228
                                                        ..:|
Mouse   722 --------------------------------------------KHDC----------------- 725

  Fly  1229 IVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVT 1293
                     |||::|.||..||. ..|.:|:::|.||.||:|||..|.|||.:|.|::.....:|
Mouse   726 ---------ALVISGDSLEVCLK-YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLT 780

  Fly  1294 LAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRY 1358
            .|:|||.||||||:.:..|||:.|:||.||.|::|:||.||::|.|||:||||.||.|.....::
Mouse   781 CAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQF 845

  Fly  1359 FFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRL 1423
            ..:::...:.....:|....|::..::....|..|:..||..||.:| |.::||..:.::.:|.|
Mouse   846 VIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLDKDVKSEVAMLYPEL 909

  Fly  1424 YTPGLKSELFNIREF-------IY---SVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLG 1478
            |...||....:.:.|       ||   ::::||   |:||                 .|:.:.:.
Mouse   910 YKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGA---LLLF-----------------ESEFVHIV 954

  Fly  1479 AVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDLTF 1543
            |:..|.||:.....::|....|..:..|....||..|.....|.:..|...::.:|:      ..
Mouse   955 AISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLS------FL 1013

  Fly  1544 WVTMLITVMALVAPVLAYKF 1563
            |...:||:::.: |:...|:
Mouse  1014 WKVSVITLVSCL-PLYVLKY 1032

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	124/406 (31%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	175/599 (29%)
Atp9a	NP_056546.2	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	326/1325 (25%)
		Cation_ATPase	464..571	CDD:463817	33/106 (31%)