Protein Alignment ATP8B and Atp8a1

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_017176112.1
• Gene: Atp8a1 / 11980
• MGIID: 1330848
• Length: 1177
• Species: Mus musculus
• Alignment Length: 1529
• Identity: 501/1529 - (32%)
• Similarity: 707/1529 - (46%)
• Gaps: 431/1529 - (28%)

  Fly   138 SLAPG-------------GGNPPP--NKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSSY 187
            |:|||             |...||  .|:||           .||..|:..
Mouse     6 SMAPGSSYSGRGRLTHNQGARKPPGYEKTDD-----------VSEKTSLAD-------------- 45

  Fly   188 YFSENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPA 252
              .|..|.|..|..:..   |:.||::.|:||::.||||..|..||:|.||.:||.:.:||.||.
Mouse    46 --QEEVRTIFINQPQLT---KFCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPD 105

  Fly   253 ISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVI 317
            :|.....||.:||:.:|.:.|:|:..:||:||.:|:.||.::::.||||......|.:|.||:::
Mouse   106 VSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWEKVAVGEIV 170

  Fly   318 RLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIIC 382
            ::.|.:.:.||.|.||:|||..:|:|||:.||||||||.:|.|..|.::.| .|||...:|.|.|
Mouse   171 KVTNGEHLPADLLSLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKD-IDSLMRISGRIEC 234

  Fly   383 ERPNNLLNKFDGTLIWRGQ-RFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFK 446
            |.||..|..|.|.:...|. ...|..::|||||..||||||.:|:||:.|.||||||||.....|
Mouse   235 ESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPLK 299

  Fly   447 STGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGL-IGQHFQLYLPWEHIIPKDYIPTGATVIG 510
            .:.|:|:.|..|:.:...|:::..:.::|.|||... .|:.:.|:|.:          .||:..|
Mouse   300 LSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHY----------GGASNFG 354

  Fly   511 LLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQY 575
             |.|.::.|:.|.::||||.|::||::|.|::.||||.:|:|..|:|.|.|||:.|||||||::|
Mouse   355 -LNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKY 418

  Fly   576 IFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVA 640
            ||||||||||.|:|.|.||:|.|.:||.|                          |.|
Mouse   419 IFSDKTGTLTCNVMQFKKCTIAGVAYGHV--------------------------PEP------- 450

  Fly   641 PPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSA 705
                                                                             
Mouse   451 ----------------------------------------------------------------- 450

  Fly   706 PSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQ 770
                :|.             |.||
Mouse   451 ----EDY-------------GCSP----------------------------------------- 457

  Fly   771 QTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAF 835
                                                      ||
Mouse   458 ------------------------------------------DE--------------------- 459

  Fly   836 ATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHV---FFRLLALCHTVMA 897
               |.||       |..|       |..|.  |.:|||.::::...:.:   |..::|:|||.:.
Mouse   460 ---WQSS-------QFGD-------EKTFN--DPSLLDNLQNNHPTAPIICEFLTMMAVCHTAVP 505

  Fly   898 ETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMS 962
            |....|:.|||.||||.|||.||:...|||..|||:|:.|:.:||.|.|||||:|:|.:.|||||
Mouse   506 EREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEERYELLNVLEFTSARKRMS 570

  Fly   963 VILRR-GDSMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYND 1026
            |::|. ...:.|||||||.|||:|| ......|..|..||.:||.||||||..|...::|..:.:
Mouse   571 VVVRTPSGKLRLYCKGADTVIYERL-AETSKYKEITLKHLEQFATEGLRTLCFAVAEISESDFEE 634

  Fly  1027 WRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTG 1091
            ||:....|:.|:.:|..||...||.||..:||:|.|||||||||.||::|..|..|.||||:|||
Mouse   635 WRAVYHRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKADIKIWILTG 699

  Fly  1092 DKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSD 1156
            ||||||||||:||:||...:..:.|.:|
Mouse   700 DKQETAINIGHSCRLLKRNMGMIVINEG------------------------------------- 727

  Fly  1157 SNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGS 1221
             ::|....|:                                         |..|..| ||....
Mouse   728 -SLDGTRETL-----------------------------------------SRHCTTL-GDALRK 749

  Fly  1222 EDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK 1286
            |:            .|||:::|.:|.:.|:..:...|||:|..|||||||||:||||:.|||::|
Mouse   750 EN------------DFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVK 802

  Fly  1287 RAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYR 1351
            :....:||||||||||||||:.||:||||||.|||||..|||||||||:||:.||:|||.|:|.|
Mouse   803 KQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWNYNR 867

  Fly  1352 MCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKN 1416
            :.|.:.|.||||....:...|::...|||.|.:|:...|.:||:.:|::|.|.||:||:....:|
Mouse   868 VSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKEN 932

  Fly  1417 SLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDG-VSANGFVVSDHMTLGAV 1480
            .|::|.||.....:..||.:.|....|:|.|.|::||..|....:.| |..|| ..||::.||..
Mouse   933 MLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTVFGNG-KTSDYLLLGNF 996

  Fly  1481 VATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYV-------GSLTQAM 1538
            |.|.:::....:..|.|||||..:|:.||||:..:.|  :|..|....|.|       |......
Mouse   997 VYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVV--FFGIYSSLWPAVPMAPDMSGEAAMLF 1059

  Fly  1539 KDLTFWVTML-ITVMALVAPVLAYKFYLLDVHPSLSDKI---------------------RQKSL 1581
            ....|||.:| |.|.:|:..|| ||........:|.|::                     |.:.|
Mouse  1060 SSGVFWVGLLSIPVASLLLDVL-YKVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLL 1123

  Fly  1582 KKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQE 1615
            |.:..:...::.|:.|.   ::::..||||:..|
Mouse  1124 KNVFKKNHVNLYRSESL---QQNLLHGYAFSQDE 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	172/392 (44%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	238/571 (42%)
Atp8a1	XP_017176112.1	ATPase-Plipid	62..1099	CDD:273734	473/1383 (34%)