DRSC/TRiP Functional Genomics Resources

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Protein Alignment ATP8B and ATP8A1

DIOPT Version :9

Sequence 1:NP_731669.2 Gene:ATP8B / 41469 FlyBaseID:FBgn0037989 Length:1726 Species:Drosophila melanogaster
Sequence 2:XP_011511917.1 Gene:ATP8A1 / 10396 HGNCID:13531 Length:1171 Species:Homo sapiens


Alignment Length:1489 Identity:489/1489 - (32%)
Similarity:710/1489 - (47%) Gaps:385/1489 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 VPSLRR-LSQIRRRRSSYYFSE--NERRIRANDKEFNAQF-------KYHNNYIKTSKYSLFTFL 225
            :|::|| :|:||.|...|..::  :|:...|:.:|....|       |:.||::.|:||::.|||
Human     1 MPTMRRTVSEIRSRAEGYEKTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFL 65

  Fly   226 PFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQV 290
            |..|..||:|.||.:||.:.:||.||.:|.....||.:||:.:|.:.|:|:..:||:||.:|:.|
Human    66 PRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAV 130

  Fly   291 NNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEPNGLCFIETAELDGETNLK 355
            |.::::.||||......|.:|.|||::.:...:::.|||:|||:|||..:|:|||:.||||||||
Human   131 NKKQTQVLRNGAWEIVHWEKVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLK 195

  Fly   356 AKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQ-RFALDNEKILLRGCVLRN 419
            .:|.|..|.::.| .|||...:|.|.||.||..|..|.|.:...|. ...|..::|||||..|||
Human   196 IRQGLPATSDIKD-VDSLMRISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRN 259

  Fly   420 TQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFIIIGIVLFLVSICALFAIGCAIWEGL-I 483
            |||.:|:||:.|.||||||||.....|.:.|:|:.|..|:.:...|:::..:.::|.|||... .
Human   260 TQWVHGIVVYTGHDTKLMQNSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHS 324

  Fly   484 GQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYAIVLNTVVPISLYVSVEVIRFVQSFLINWDE 548
            |:.:.|.|.:          .||:..| |.|.::.|:.|.::||||.|::||::|.|::.||||.
Human   325 GKDWYLNLNY----------GGASNFG-LNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDL 378

  Fly   549 EMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLTQNIMTFNKCSINGRSYGDVIDLRTGELV 613
            :|:|..|:|.|.|||:.|||||||::|||||||||||.|:|.|.||:|.|.:||.|         
Human   379 DMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTGTLTCNVMQFKKCTIAGVAYGHV--------- 434

  Fly   614 EITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRP 678
                             |.|                                             
Human   435 -----------------PEP--------------------------------------------- 437

  Fly   679 RSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAGRLSPRLDGSGGLSPPVGNEERRISGGFK 743
                                           :|.             |.||              
Human   438 -------------------------------EDY-------------GCSP-------------- 444

  Fly   744 RSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMHHSSHNRKRLVKIRFKKAPSTATLGVVISQL 808
                                                                             
Human   445 ----------------------------------------------------------------- 444

  Fly   809 EHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLD 873
                ||                        |.:|       |..|       |..|.  |.:||:
Human   445 ----DE------------------------WQNS-------QFGD-------EKTFS--DSSLLE 465

  Fly   874 AVRSDEEHSHV---FFRLLALCHTVMAETVDGKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSI 935
            .::::...:.:   |..::|:|||.:.|....|:.|||.||||.|||.||:...|||..|||:|:
Human   466 NLQNNHPTAPIICEFLTMMAVCHTAVPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSV 530

  Fly   936 TIEVMGQTEEYELLNILDFNNVRKRMSVILRR-GDSMVLYCKGADNVIYDRLHGGQEDLKARTQD 999
            .|:.:||.|.|||||:|:|.:.|||||||:|. ...:.|||||||.|||||| ......|..|..
Human   531 IIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRL-AETSKYKEITLK 594

  Fly  1000 HLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIESEMQLVGVTAI 1064
            ||.:||.||||||..|...::|..:.:||:..|.|:.|:.:|..||...||.||..:||:|.|||
Human   595 HLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAI 659

  Fly  1065 EDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDGNSVEEVEKQL 1129
            ||||||.||::|..|..|.||||:|||||||||||||:||:||...:..:.|.:| |::..::.:
Human   660 EDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEG-SLDVEDRAV 723

  Fly  1130 RQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFR 1194
            ...:|::                                                          
Human   724 EGTRETL---------------------------------------------------------- 730

  Fly  1195 WDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFL 1259
                         |..|..| ||....|:            .|||:::|.:|.:.|:..:...||
Human   731 -------------SRHCTTL-GDALRKEN------------DFALIIDGKTLKYALTFGVRQYFL 769

  Fly  1260 DIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAV 1324
            |:|..|||||||||:||||:.|||::|:....|||||||||||||||:.||:||||||.|||||.
Human   770 DLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTAHVGVGISGNEGLQAA 834

  Fly  1325 LSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMF 1389
            .|||||||||:||:.||::||.|:|.|:.|.:.|.||||....:...|::...|||.|.:|:...
Human   835 NSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWC 899

  Fly  1390 ISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFL 1454
            |.:||:.:|::|.|.||:||:....:|.|::|.||.....:..||.:.|....|:|.|.|::||.
Human   900 IGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFW 964

  Fly  1455 IPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLD 1519
            .|....:.|.:......||::.||..|.|.:::....:..|.|||||..:|:.||||:..:.|  
Human   965 FPLKALQYGTAFGNGKTSDYLLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVV-- 1027

  Fly  1520 YFYNYVIGGPYV-------GSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKI- 1576
            :|..|....|.:       |..........||:.:|...:|.:...:.||........:|.|:: 
Human  1028 FFGIYSSLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVYKVIKRTAFKTLVDEVQ 1092

  Fly  1577 --------------------RQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQE 1615
                                |.:.||.:..:...::.|:.|.   ::::..||||:..|
Human  1093 ELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESL---QQNLLHGYAFSQDE 1148

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ATP8BNP_731669.2 PhoLip_ATPase_N 195..260 CDD:292826 26/71 (37%)
Cation_ATPase 891..985 CDD:289987 53/94 (56%)
HAD_like <1261..1324 CDD:304363 45/62 (73%)
PhoLip_ATPase_C 1324..1571 CDD:292829 84/253 (33%)
ATP8A1XP_011511917.1 PhoLip_ATPase_N 38..100 CDD:292826 24/61 (39%)
ATPase-Plipid 49..1093 CDD:273734 466/1381 (34%)
E1-E2_ATPase 106..>191 CDD:278548 34/84 (40%)
Cation_ATPase 486..581 CDD:289987 53/94 (56%)
HAD_like <803..853 CDD:304363 40/49 (82%)
PhoLip_ATPase_C 834..1086 CDD:292829 84/253 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0206
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 1 1.000 - - FOG0000076
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100089
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X168
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.730

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