DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and atp9a

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_005174184.3	Gene:	atp9a / 101886226	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	1377	Identity:	346/1377 - (25%)
Similarity:	534/1377 - (38%)	Gaps:	420/1377 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            :|..|.|...||:.|||||..|..||:...|.|||.|...|.:..:......|..:||..||.:|
Zfish    52 RYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVNELRLGALYTYWVPLGFVLIIT 116

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            .|::|.::::..:.|.:||::....|.....|:.|.|.:||||:|.::.||.|.||.:.|.|||.
Zfish   117 IVREAVEEVRCFLRDKEVNSQIYSKLSTRGTVKVKSSGIQVGDLIIVEKNQRVPADMIFLRTSER 181

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQR 402
            ||.||:.|.:|||||:.|.:..:..|..|....| |......:..|.||..::.|.||....
Zfish   182 NGSCFLRTDQLDGETDWKLRLPVACTQRLPTAAD-LLQIRSFVYAEEPNIDIHNFIGTFTRE--- 242

  Fly   403 FALDNEKILLRGCVLRNTQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVD---RLLN 455
               |.:..:.....:.||.|.         .|||::.|.:.:.:.|:...:.|....|   ..|.
Zfish   243 ---DGDPPVNESLSIENTLWASTVIASGTVVGVVIYTGKELRSVMNTSNPRHKIGLFDLEVNCLT 304

  Fly   456 FIIIG--IVLFLVSICALFAIGCAIWEGLIGQHF--QLYLPWEHIIPKDYIPTGATVIGLLVFFS 516
            .|:.|  :|:.||.:..              |||  :.||.                     .|.
Zfish   305 KILFGALVVVSLVMVAL--------------QHFAGRWYLQ---------------------IFR 334

  Fly   517 YAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKT 581
            :.::.:.:|||||.|::::.:.|.|::|..|.::  |.|    ..|.:|:.|:||:|.|:.:|||
Zfish   335 FLLLFSNIVPISLRVNLDMGKMVFSWMIKKDSKI--PGT----VVRASTIPEQLGRISYLLTDKT 393

  Fly   582 GTLTQNIMTFNKCSINGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            ||||||.|.|.:..:...:|| |.:|       |:  |..:|             .|...||
Zfish   394 GTLTQNEMVFRRLHLGTVAYGMDSMD-------EV--QSHVF-------------SAYTQPP--- 433

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                                              .|::.|        :.||...||.:..||..
Zfish   434 ----------------------------------QDLQAS--------RAPGATKVRKTISSRVH 456

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775
            :|                                                  ||.:     ...|
Zfish   457 EA--------------------------------------------------VKAI-----ALVH 466

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840
            |:                 .|.....||. .|.|
Zfish   467 NV-----------------TPVYEANGVT-DQAE------------------------------- 482

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLE 905
                           |..|:|...|                                       .
Zfish   483 ---------------AEQHYEDTCR---------------------------------------V 493

  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEV-MGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            |||.||||.:||....:.|.....|..:|:.:.. .||...:.:|.|..|....|||.:|:|...
Zfish   494 YQASSPDEVSLVQWTESVGLTLVGRDQSSMQLRTPSGQILNFTILQIFPFTYESKRMGIIVRDES 558

  Fly   970 S--MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032
            :  :..|.||||.|:     .|........::.....|.||||.|.:|::.|||:.|.|:.:|..
Zfish   559 TGEITFYMKGADVVM-----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLTEEQYQDFEARYV 618

  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097
            :|.||:..|..|:..:.|.:|.||:|:.:|.:||:||..|..::..|:|||||:|:|||||.|||
Zfish   619 QAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLEILRNAGIKVWMLTGDKLETA 683

  Fly  1098 INIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPL 1162
            .....:..|:|.. .|:.:                         |||
Zfish   684 TCTAKNAHLVTRN-QDIHV-------------------------FRP------------------ 704

  Fly  1163 SVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTA 1227
             || |::.|.: |.|              .||  .|:          :|
Zfish   705 -VT-TRSEAHL-ELN--------------AFR--RKH----------DC---------------- 724

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                      |||::|.||..||. ..|.:|:::|.||.||:|||..|.|||.:|.|::.....:
Zfish   725 ----------ALVISGDSLEVCLK-YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKL 778

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |.|:|||.||||||:.|..|||:.|:||.||.|::|:||.||::|.|||:||||.||.|.....:
Zfish   779 TCAVGDGGNDVSMIQEADCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQ 843

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            :..:::...:.....:|....|::..::....|..|:..||..||.:| |.::||..:.::.:|.
Zfish   844 FVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLDKDVKSEVAMLYPE 907

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVV---SDHMTLGAVVATI 1484
            ||...||....:.:.|:..||             ..:|:..:...|.::   |:.:.:.|:..|.
Zfish   908 LYKDLLKGRPLSFKTFLIWVL-------------ISIYQGSIIMYGALLLFESEFVHIVAISFTS 959

  Fly  1485 LIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDLTFWVTMLI 1549
            ||:.....::|....|..:..|....||..|.....|.:..|...::.:|:...|     ||.:.
Zfish   960 LILTELLMVALTIQTWHWLMIVAELLSLACYIASLVFLHEFIDVYFIATLSFIWK-----VTAIT 1019

  Fly  1550 TVMALVAPVLAY 1561
            .:..|...:|.|
Zfish  1020 LISCLPLYILKY 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	19/51 (37%)
		Cation_ATPase	891..985	CDD:289987	28/96 (29%)
		HAD_like	<1261..1324	CDD:304363	33/62 (53%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	59/241 (24%)
atp9a	XP_005174184.3	P-type_ATPase_APLT_Neo1-like	55..966	CDD:319841	330/1302 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.020