Protein Alignment ATP8B and atp8a2

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_012813389.2
• Gene: atp8a2 / 101730757
• XenbaseID: XB-GENE-6036032
• Length: 1197
• Species: Xenopus tropicalis
• Alignment Length: 1454
• Identity: 475/1454 - (32%)
• Similarity: 680/1454 - (46%)
• Gaps: 402/1454 - (27%)

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            |:.:|.:.|:|||:.||||..|.||.:|.||.:||.:.:||.||.:|.....||.:|||.:||:.
 Frog    77 KFRDNTVSTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIFILTVA 141

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            .:|:..:|.:||.:|:.||.:|:..|:.|......|.||.|||::::.|.|.:.||.::||:|||
 Frog   142 GIKEIIEDYKRHKADNTVNKKKTIVLKGGTWQNMVWREVAVGDIVKVTNGQHLPADMIILSSSEP 206

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQR 402
            ..:|:|||:.||||||||.:|.|..|..|....| |....|.|.||.||..|..|.|.|     |
 Frog   207 QAMCYIETSNLDGETNLKIRQGLPATSNLLSEED-LVKMTGRIECEGPNRHLYDFIGNL-----R 265

  Fly   403 FALDN------EKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLN---FII 458
            ...:|      |:|||||..:|||||..|:||:.|.||||||||.|...|.:.|:::.|   .::
 Frog   266 LGTNNPVPVGPEQILLRGAQIRNTQWVIGIVVYTGHDTKLMQNSTKAPLKRSNVEKVTNVQILVL 330

  Fly   459 IGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDY---IPTGATVIG--LLVFFSYA 518
            .||:|.:..:.   ::|..:|.            |::.....|   |...:|..|  ||.|.
 Frog   331 FGILLVMALVS---SVGALLWN------------WKYEGTNWYLGDIDAVSTNFGYNLLTFI--- 377

  Fly   519 IVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGT 583
            |:.|.::||||.|::||::|.|:..||||.:|||..|:|.|.|||:.|||||||::|:|||||||
 Frog   378 ILYNNLIPISLLVTLEVVKFTQALFINWDRDMYYSETDTPAMARTSNLNEELGQVKYLFSDKTGT 442

  Fly   584 LTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPI 648
            ||.|:|.|.||||.|.:||..
 Frog   443 LTCNVMHFKKCSIGGITYGHF-------------------------------------------- 463

  Fly   649 ILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDAD 713
                                         |..:.|||                       |:|
 Frog   464 -----------------------------PEFERERS-----------------------SED-- 474

  Fly   714 AGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMH 778
                                                                             
 Frog   475 ----------------------------------------------------------------- 474

  Fly   779 HSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSP 843
                         |.:.|:|:
 Frog   475 -------------FSQLPTTS-------------------------------------------- 482

  Fly   844 HRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHV---FFRLLALCHTVMAETVDGKLE 905
                  :|.||.            |..|...:.:|......   |..|||:||||:.|..:..:.
 Frog   483 ------ESCDFD------------DPKLFQNIENDSPTGDTIKEFLTLLAVCHTVVPEKDEDTII 529

  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRR-GD 969
            |||.||||.|||..||..|:.|..|||:|:.|:.||:.:.:||||:|:|::.|||||||:|. ..
 Frog   530 YQASSPDEGALVKGARKLGYTFTGRTPDSVIIDAMGKEQSFELLNVLEFSSNRKRMSVIVRTPSG 594

  Fly   970 SMVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEA 1034
            ::.||||||||||::|| ..:.....:|.:||.:||.||||||.||...|.:..|..|.:...||
 Frog   595 NLRLYCKGADNVIFERL-SRESKYMEQTLNHLEQFASEGLRTLCLAYCDLQDSEYEAWLNVHSEA 658

  Fly  1035 ALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAIN 1099
            ::.:..|.|||...||.||.::.|:|.|||||:||.|||::||.|..|.||||||||||||||:|
 Frog   659 SVVIKDRAQKLEECYEIIEKDLMLLGATAIEDRLQGGVPETIATLMKAEIKIWVLTGDKQETAVN 723

  Fly  1100 IGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSV 1164
            |||||:|::..::.:.:                                     |.|| :|....
 Frog   724 IGYSCRLVSQTMSLIVV-------------------------------------NEDS-LDATRS 750

  Fly  1165 TMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASI 1229
            |:|.                                         .|.|| ||..|.|:
 Frog   751 TLTN-----------------------------------------HCTNL-GDGLGKEN------ 767

  Fly  1230 VVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTL 1294
                  ..||:::|.:|.:.||.|:...|||:|..|||||||||:||||:.:|:::|:..||:||
 Frog   768 ------DLALIIDGQTLKYALSFEVRQSFLDLALSCKAVICCRVSPLQKSEIVDMVKKHVNAITL 826

  Fly  1295 AIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYF 1359
            |||||||||.||:.||:||||||.||:||..:|||:||||.|||:||||||.|||.|:.|.:.|.
 Frog   827 AIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFCYLEKLLLVHGAWSYNRVTKCILYC 891

  Fly  1360 FYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLY 1424
            ||||....:...|:::..|||.|.:|:...|.:||:.:|:||...||:.|:..|..:.|.||:||
 Frog   892 FYKNVVLYIIELWFAVVNGFSGQVLFERWCIGLYNVIFTALPPFTLGICERSCSQDSMLRFPQLY 956

  Fly  1425 TPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYK-DGVSANGFVVSDHMTLGAVVATILIVD 1488
            .....::.||.|.|....::....|::||..|..:.: |.|..|| .|:|::.:|.:|.|.::|.
 Frog   957 KITQNADGFNTRVFWGHCINALIHSIILFWFPLKMLEHDAVFTNG-QVTDYLFVGNIVYTYVVVT 1020

  Fly  1489 NTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYV-----IGGPYVGSLTQAMKDLTFWVTML 1548
            ...:..|.|:.||..:|:.:|||::.:.|....|:.:     |....:|.....:....||:.:|
 Frog  1021 VCLKAGLETTAWTKFSHLAVWGSMLMWLVFFGAYSAIWPTIPIAPDMLGQAGMVLTSGYFWLGLL 1085

  Fly  1549 ITVMALVAPVLAYKFYLLDVHPSLSDKI-----RQKSLKKIHSRASS----DVRRTASSRRGRR- 1603
            :...|.:...:.::......|.:|.:::     |.|.:.|...|.|:    :.|.....|.||:
 Frog  1086 LVPTACLLRDVTWRAAKHTYHKTLLEQVQEIETRAKEMSKAAMRDSNGKSLNERDHLLRRLGRKT 1150

  Fly  1604 ------------SVRSGYAFAHQE 1615
                        ||..||||:.:|
 Frog  1151 PPSLFRANSVQQSVSYGYAFSQEE 1174

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	23/51 (45%)
		Cation_ATPase	891..985	CDD:289987	50/94 (53%)
		HAD_like	<1261..1324	CDD:304363	42/62 (68%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	82/252 (33%)
atp8a2	XP_012813389.2	ATPase-Plipid	78..1115	CDD:273734	458/1392 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010