DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and ATP9A

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	NP_006036.1	Gene:	ATP9A / 10079	HGNCID:	13540	Length:	1047	Species:	Homo sapiens

Alignment Length:	1387	Identity:	336/1387 - (24%)
Similarity:	534/1387 - (38%)	Gaps:	437/1387 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVLTLT 272
            :|..|.|...||:.|||||..|..||:...|.|||.|...|.:|.:......|..:||..||.:|
Human    52 RYPRNVINNQKYNFFTFLPGVLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVT 116

  Fly   273 AVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAADTLLLSTSEP 337
            .:::|.::|:.::.|.:||::....|.....|:.|.|.:||||:|.::.||.|.||.:.|.|||.
Human   117 VIREAVEEIRCYVRDKEVNSQVYSRLTARGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEK 181

  Fly   338 NGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKFDGTLIWRGQR 402
            ||.||:.|.:|||||:.|.:..:..|..|....| |......:..|.||..::.|.||....
Human   182 NGSCFLRTDQLDGETDWKLRLPVACTQRLPTAAD-LLQIRSYVYAEEPNIDIHNFVGTFTRE--- 242

  Fly   403 FALDNEKILLRGCVLRNTQWC---------YGVVVFAGVDTKLMQNSGKTQFKSTGVD---RLLN 455
               |::..:.....:.||.|.         .|||::.|.:.:.:.|:...:.|....|   ..|.
Human   243 ---DSDPPISESLSIENTLWAGTVVASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLT 304

  Fly   456 FIIIG--IVLFLVSICALFAIGCAIWEGLIGQHF--QLYLPWEHIIPKDYIPTGATVIGLLVFFS 516
            .|:.|  :|:.||.:..              |||  :.||               .:|..|:.||
Human   305 KILFGALVVVSLVMVAL--------------QHFAGRWYL---------------QIIRFLLLFS 340

  Fly   517 YAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKT 581
                  .::||||.|::::.:.|.|::|..|.::  |.|    ..|::|:.|:||:|.|:.:|||
Human   341 ------NIIPISLRVNLDMGKIVYSWVIRRDSKI--PGT----VVRSSTIPEQLGRISYLLTDKT 393

  Fly   582 GTLTQNIMTFNKCSINGRSYG-DVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            ||||||.|.|.:..:...:|| |.:|.....:..|..||
Human   394 GTLTQNEMIFKRLHLGTVAYGLDSMDEVQSHIFSIYTQQ-------------------------- 432

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                                                                           ||
Human   433 ---------------------------------------------------------------SQ 434

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775
            |                 ||.
Human   435 D-----------------PPA-------------------------------------------- 438

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840
                             :|.|:..|                :...|:|:..|...::.|...|
Human   439 -----------------QKGPTLTT----------------KVRRTMSSRVHEAVKAIALCHN-- 468

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMAETVDGKLE 905
                           ..|.:||:      .:.|...:::::.                  |....
Human   469 ---------------VTPVYESN------GVTDQAEAEKQYE------------------DSCRV 494

  Fly   906 YQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMG-QTEEYELLNILDFNNVRKRMSVILRRGD 969
            |||.||||.|||....:.|.....|..:|:.:...| |...:.:|.|..|....|||.:|:|...
Human   495 YQASSPDEVALVQWTESVGLTLVGRDQSSMQLRTPGDQILNFTILQIFPFTYESKRMGIIVRDES 559

  Fly   970 S--MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQ 1032
            :  :..|.||||.|:     .|........::.....|.||||.|.:|::.|.|:.|.|:.:|..
Human   560 TGEITFYMKGADVVM-----AGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEEQYQDFEARYV 619

  Fly  1033 EAALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETA 1097
            :|.||:..|..|:..:.|.:|.||:|:.:|.:||:||..|..::..|:|||||:|:|||||.|||
Human   620 QAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVWMLTGDKLETA 684

  Fly  1098 INIGYSCQLLT-DELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDP 1161
            .....:..|:| ::...||.:..|. .|...:|..|:.
Human   685 TCTAKNAHLVTRNQDIHVFRLVTNR-GEAHLELNAFRR--------------------------- 721

  Fly  1162 LSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGT 1226
                                                          ..:|
Human   722 ----------------------------------------------KHDC--------------- 725

  Fly  1227 ASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNA 1291
                       |||::|.||..||. ..|.:|:::|.||.||:|||..|.|||.:|.|::.....
Human   726 -----------ALVISGDSLEVCLK-YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGK 778

  Fly  1292 VTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFL 1356
            :|.|:|||.||||||:.:..|||:.|:||.||.|::|:||.||::|.|||:||||.||.|.....
Human   779 LTCAVGDGGNDVSMIQESDCGVGVEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALS 843

  Fly  1357 RYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFP 1421
            ::..:::...:.....:|....|::..::....|..|:..||..||.:| |.::||..:.::.:|
Human   844 QFVIHRSLCISTMQAVFSSVFYFASVPLYQGFLIIGYSTIYTMFPVFSL-VLDKDVKSEVAMLYP 907

  Fly  1422 RLYTPGLKSELFNIREF-------IY---SVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMT 1476
            .||...||....:.:.|       ||   ::::||   |:||                 .|:.:.
Human   908 ELYKDLLKGRPLSYKTFLIWVLISIYQGSTIMYGA---LLLF-----------------ESEFVH 952

  Fly  1477 LGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDYFYNYVIGGPYVGSLTQAMKDL 1541
            :.|:..|.||:.....::|....|..:..|....||..|.....|.:..|...::.:|:
Human   953 IVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLHEFIDVYFIATLS------ 1011

  Fly  1542 TFWVTMLITVMALVAPVLAYKF 1563
            ..|...:||:::.: |:...|:
Human  1012 FLWKVSVITLVSCL-PLYVLKY 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	20/51 (39%)
		Cation_ATPase	891..985	CDD:289987	30/96 (31%)
		HAD_like	<1261..1324	CDD:304363	32/62 (52%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	61/250 (24%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	321/1310 (25%)
ATP9A	NP_006036.1	Cation_ATPase	464..571	CDD:404183	33/147 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930