Protein Alignment ATP8B and atp10a

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_002931688.2
• Gene: atp10a / 100494528
• XenbaseID: XB-GENE-6033735
• Length: 1492
• Species: Xenopus tropicalis
• Alignment Length: 1660
• Identity: 504/1660 - (30%)
• Similarity: 797/1660 - (48%)
• Gaps: 335/1660 - (20%)

  Fly   142 GGGNPPPNKSDDQELYKQRDPSVTSESKSVPSLRRLSQIRRRRSS--YYFSENERRIRANDKEFN 204
            |||.|....:.|:|...:|       .|.....||.|::|..||:  .|.|:|..|:
 Frog     6 GGGEPKCQAAKDEEDNVKR-------KKKKRKTRRESRVRTVRSNLLLYESDNPNRL-------- 55

  Fly   205 AQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTPVTTAIPLIGVL 269
                |..|.|||:||:..:|||.||.|||.||||.||:.:.:|..:||:::..|.....|::.:|
 Frog    56 ----YAGNSIKTTKYTALSFLPKNLFEQFHRLANVYFVFMALLNFVPAVNAFKPELALAPVLFIL 116

  Fly   270 TLTAVKDAYDDIQRHISDSQVNN-------RKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQFVAA 327
            .:||:||.::|.:|:.||.::|:       |..|..|     |..|.||||||.::|..|:.:.|
 Frog   117 AVTAIKDLWEDYRRYRSDKEINHMDCLVFCRSEKKYR-----EKYWKEVQVGDFVQLRCNEIIPA 176

  Fly   328 DTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNLLNKF 392
            |.||||:|:|:|||.||||.||||||||.:|.:...:||....|.: .|...|.||:|||.|.:|
 Frog   177 DILLLSSSDPDGLCHIETANLDGETNLKQRQVVKGFVELESEFDPM-TFKSIIECEKPNNDLTRF 240

  Fly   393 DGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRLLNFI 457
            .|.:...|::..|..|.:|||||.:|||:...|:|::||.:||.:.|:...::|.:.::|.:|..
 Frog   241 RGYIHKNGKKSGLFKENLLLRGCTIRNTEVVSGIVIYAGHETKALLNNNGPRYKRSKLERQMNKD 305

  Fly   458 IIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKD--YIPTGATVIGLLVFFSYAIV 520
            :...||.|:.:|...|:|.|:|....|:...::    .::..|  |:....:.:.|  ||:..||
 Frog   306 VFWCVLILLIMCLFSAVGHALWVWQYGEKRPVF----DVLGSDGKYVKPFLSAVYL--FFTMIIV 364

  Fly   521 LNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGTLT 585
            |..::|:|||||:|:::..|.:.|:.|:::|...|::..:.|...:.|:||||||:|||||||||
 Frog   365 LQVLIPVSLYVSIEIVKICQVYFIHQDKDLYDEETDSQLQCRALNITEDLGQIQYVFSDKTGTLT 429

  Fly   586 QNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPIIL 650
            :|.|.|.:|:::|..|..         .:..::..::|.:::.:
 Frog   430 ENKMVFRRCTVSGVEYSH---------DDNAKRLAMYQEADSED--------------------- 464

  Fly   651 VHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDADAG 715
                ||:..||..:             ||.|...|...:.|:.:....|..|.:. ||::...|.
 Frog   465 ----EVNGPKTGTL-------------PRRDSSGSHHSVKAAHRSQSTKTHRRTG-SRAEAMKAN 511

  Fly   716 RLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDK-VKILHDSQQ-------- 771
            .||...    ..|.|:   |:.|:...|..         .:.:.|.| :||:.:.:|
 Frog   512 ILSKHT----AFSSPM---EKDITPDPKLQ---------EKVNECAKTLKIMRNHKQPFSQLTAE 560

  Fly   772 -----------TETHNMHHSSHNRKR-LVKIRF--------------KKAPSTATLGVVISQLEH 810
                       |..:.:..:|.|:.| .|::||              :..||..|.|
 Frog   561 LSDIFDFFTALTICNTVVVTSPNQPRQKVRVRFELKSPVKTIEDFIRRFTPSRLTSG-------- 617

  Fly   811 HLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAV 875
               ....|:|:|.|.|..|   :|.::..|||        |:        |..|...:|.|
 Frog   618 ---SNSSSSSSLGTNKSMH---RAGSSIMSSS--------SI--------EGSFTKLERKL---- 656

  Fly   876 RSDEEHSHVFFRLLALCHTVMAETVD---GKLEYQAQSPDEAALVSAARNFGFVFRTRTPNSITI 937
               .....:.|..|. ......|.||   |.|.::|:||||||||.|:|.:......|..:.:|:
 Frog   657 ---SSSPQINFTGLG-TQPGFKEQVDGHEGDLRFEAESPDEAALVYASRAYNCALVGRLSDQVTV 717

  Fly   938 EV--MGQTEEYELLNILDFNNVRKRMSVILRR--GDSMVLYCKGADNVIY---------DRLHGG 989
            |:  :|:. .:|||:.|.|::|||||||::|.  .|.:|:|.||||:||.         |||...
 Frog   718 ELPHLGRL-NFELLHTLGFDSVRKRMSVVVRHPLTDEIVVYAKGADSVILDLIQPCSKDDRLGKH 781

  Fly   990 QEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAALSMDSREQKLNAIYEEIES 1054
            |..::|:||.:||.:|.:|||||.:|:|.|:::.|..|.....:|..|:|:||:.|......:|:
 Frog   782 QRKIQAKTQKYLNCYAVDGLRTLCIAKRVLSKEEYACWLKFHLQAESSLDNREELLFQSAVRLET 846

  Fly  1055 EMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIGYSCQLLTDELADVFIVDG 1119
            .:.|:|.|.|||:||:|||::|..|:.|||:||||||||||||:||||||:|| |...|:..::.
 Frog   847 NLHLLGATGIEDRLQEGVPETITRLRKAGIQIWVLTGDKQETAVNIGYSCKLL-DHEDDLITLNA 910

  Fly  1120 NSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTMTQTSAFMQETNLPPTPPP 1184
            .|:||....|.|....|:  ::|..|                           :||..:..|
 Frog   911 ESLEECSTLLEQCLHYIQ--SKFSSG---------------------------LQEKVVGGT--- 943

  Fly  1185 PPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHC 1249
                                |.||.:.|.|:....             :.:...||::|.:|...
 Frog   944 --------------------GIDSVQHNTLWPPNL-------------KQSSLGLVIDGKTLAFA 975

  Fly  1250 LSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVG 1314
            |.....:|||.:|.:|::|:|||.|||||:|||:|::....|:|||:|||.||||||:.|.:|||
 Frog   976 LDITQSDKFLLLARKCRSVLCCRSTPLQKSLVVKLVRDKLRAMTLAVGDGTNDVSMIQVADVGVG 1040

  Fly  1315 ISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGF 1379
            ||||||:|||::||:::.:||:||:||||||||.|.|:...:.||||||..|.....||..:|||
 Frog  1041 ISGQEGMQAVMASDFAVPRFRHLEKLLLVHGRWCYSRLANMVLYFFYKNAMFVALLFWYQFYCGF 1105

  Fly  1380 SAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLH 1444
            |...:.|..::..:||.::|:|.|..|:.::|:..:.....|.||..|...|.:....|..:::.
 Frog  1106 SGSAMIDQWYLIFFNLLFSSIPQLITGILDKDLPAELLTANPELYKSGPNMEEYKPHMFWLNMID 1170

  Fly  1445 GAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIW 1509
            ..:.|||.|.|||..:.|.       ..|..|.|..:.|..::.....:.:.|..||.:|..:|.
 Frog  1171 AFYQSLVCFFIPYFSFFDS-------DIDLFTWGTPIVTCALLTIMMHLGMETKTWTWINVSSIV 1228

  Fly  1510 GSLVWYFVLDYFYNYVI------GGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDV 1568
            .|::.:|.:...||...      ..|| .::.:.|.:..|::..:::.:..:.|...||.....:
 Frog  1229 FSILLFFTVALVYNSSCPTCNPPSNPY-WTMQKLMANPLFYLICILSPVTALLPRFLYKSVQGTL 1292

  Fly  1569 HPSLSDKIRQKSLKKIHSRASSDVRRTASSRRGRRSVRSGYAFAHQE---GFGRLITSGKIMHKL 1630
            .|:                         ..:.||:.:|     ||.|   |...::.|.....
 Frog  1293 FPT-------------------------QIQLGRKLLR-----AHPECLTGNFSILKSSTASE-- 1325

  Fly  1631 PQDFAFPLGLGTKKTQVLHNNLNSADGPNSKGNNVTGHHMVNNNTNMRHNQN----QNHSSMADI 1691
                     :.:|.|:  .||.:.|...|.:.||:.....|...::.:..:|    |::.|..|.
 Frog  1326 ---------MRSKTTE--PNNTSIALNTNQRQNNMDPEQNVKFYSSPKEERNESVDQSYCSCEDT 1379

  Fly  1692 TADGRGNGGDDGRGSGGSDDMSPRAPCQDLDTINL 1726
            :...:    |:.:.:....|.|..     |||:.|
 Frog  1380 SICVK----DEAKNTSFYHDSSVL-----LDTLPL 1405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	26/64 (41%)
		Cation_ATPase	891..985	CDD:289987	42/109 (39%)
		HAD_like	<1261..1324	CDD:304363	39/62 (63%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	72/252 (29%)
atp10a	XP_002931688.2	P-type_ATPase_APLT_Dnf-like	58..1182	CDD:319770	432/1304 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010