DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and XB994119

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_002940236.3	Gene:	XB994119 / 100490503	XenbaseID:	XB-GENE-994120	Length:	1179	Species:	Xenopus tropicalis

Alignment Length:	1457	Identity:	663/1457 - (45%)
Similarity:	849/1457 - (58%)	Gaps:	327/1457 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.|||:||||:::|.:|||..|.|||.||::|||||.||.|||||:||.||:.||:|||||.:||
Frog    15 EKERRLRANDRDYNLKFKYATNAIKTCKYNIFTFLPLNLFEQFQRVANAYFVFLLILQLIPQVSS 79

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            |:..||.:||:.||.::|||||.||..||.||:|||||..:.|.||:....||..:||||:|:|:
Frog    80 LSWFTTVVPLVLVLAVSAVKDATDDYYRHKSDNQVNNRTVQVLSNGQFTNEKWMNIQVGDIIKLE 144

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERP 385
            ||.||.||.||||:||||||.:|||||||||||||.||.||.|.:||:..:.|..|:||::||.|
Frog   145 NNNFVTADLLLLSSSEPNGLIYIETAELDGETNLKVKQSLTVTGDLGEDLEQLSRFDGEVVCEAP 209

  Fly   386 NNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGV 450
            ||.|:.|.|||.::|::::|||.|||||||.||||.||:|:|:|||.||||||||||:..|.|.:
Frog   210 NNKLDTFTGTLTYQGEKYSLDNGKILLRGCTLRNTDWCFGMVIFAGPDTKLMQNSGKSTLKRTSI 274

  Fly   451 DRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFF 515
            |||:|.:::.|.:||.::|.:.|||..|||...|.:||:||||...:      |.|...|.|:|:
Frog   275 DRLMNILVLWIFVFLAAMCIILAIGNGIWESNQGYYFQVYLPWAEGV------TNAAFSGFLMFW 333

  Fly   516 SYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDK 580
            ||.|:||||||||||||||:||...|:.||||.:||||..:|.|:|||||||||||||:||||||
Frog   334 SYVIILNTVVPISLYVSVEIIRLGNSYYINWDRKMYYPKKDTPAEARTTTLNEELGQIKYIFSDK 398

  Fly   581 TGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            ||||||||||||||||||.|||||.|. .|..:||.|
Frog   399 TGTLTQNIMTFNKCSINGNSYGDVYDY-AGNRLEINE---------------------------- 434

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                       |.:|
Frog   435 -----------HTEK-------------------------------------------------- 438

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775

Frog   439 ----------------------------------------------------------------- 438

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840

Frog   439 ----------------------------------------------------------------- 438

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA-ETVDGKL 904
                       ||||.||..:..|.::|..|:::|:..|..:|.||||||||||.|: |...|:|
Frog   439 -----------VDFSFNPLADPKFSFHDHRLVESVKLGEPATHEFFRLLALCHTAMSEEKKPGEL 492

  Fly   905 EYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            .||||||||.|||:||||||||||||||.:||:..||:|:.|||..||||||.|||||||::..|
Frog   493 VYQAQSPDEGALVTAARNFGFVFRTRTPETITVVEMGETKVYELQAILDFNNERKRMSVIVKSPD 557

  Fly   970 S-MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            . ::|||||||.::|:.|....||||..|.:|||:|||||||||.||.:.|...|:.||:.|..|
Frog   558 GRLILYCKGADTIVYELLDQSSEDLKETTTEHLNEFAGEGLRTLVLACKELNPTYFRDWKQRHHE 622

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |:.|:|.||:||..:|||||.:::|:|.:|||||||||||::|..|..|.||||||||||||||.
Frog   623 ASTSLDDREEKLAKLYEEIEKDLKLLGASAIEDKLQDGVPQTIETLSKANIKIWVLTGDKQETAE 687

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            ||||||.:|.||:.:|||:.|.|.:||.::||..:      .:..|..|       |::|
Frog   688 NIGYSCNMLQDEMKEVFIIKGCSPDEVLEELRSAR------RKMNPESF-------SETN----- 734

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDE-KGSEDGGTA 1227
                :.:.::|                      :|:|.::..||         || |||:.
Frog   735 ----EVNVYLQ----------------------KKSKKSQIIPD---------DELKGSDT---- 760

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                     |.:::|||||...|...:|.:.|..|..|.|||||||||||||.||:|:|:.|.||
Frog   761 ---------FGILINGHSLAFALEESMEIELLRTACMCTAVICCRVTPLQKAQVVQLVKKYKKAV 816

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |||||||||||||||.||||||||||||:|||||||:|.||||||:|||||||||||.|||:|||
Frog   817 TLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSDFSFAQFRYLQRLLLVHGRWSYIRMCRFLR 881

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            |||||||.|||.|.||..|||||||||:|..||::|||.|||||||.:.:|:|||:|:.||:||.
Frog   882 YFFYKNFTFTLVHFWYGFFCGFSAQTVYDEWFITLYNLVYTSLPVLGMSLFDQDVNDRWSLQFPE 946

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIV 1487
            ||.||..:..|||:|||..||||.::||:||.||:|...:.|..:|..:||:.:...:..|.|::
Frog   947 LYEPGQMNRYFNIKEFIKCVLHGIYSSLILFFIPFGAMYESVREDGRAISDYQSFALMAQTCLLL 1011

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVL------DYFYNYVIGG-PYVGSLTQAMKDLTFWV 1545
            ..:.||.|.|:|||.||...||||:..||.:      |..|....|. |::|:....:.....|:
Frog  1012 VVSVQIGLDTAYWTAVNQFFIWGSMAVYFAITFTMYSDGMYLIFTGSFPFIGTARNTLNQPGVWL 1076

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR-----ASSDVRRTASSRRGRRSV 1605
            .:.:|.:..|.||:|::|...::.||..||| ||.:::...|     ..:.:|||:|.
Frog  1077 AIFLTTVLCVLPVVAFRFLRSELFPSTGDKI-QKKIREAKKRPPPPPPKARLRRTSSR------- 1133

  Fly  1606 RSGYAFAHQEGFGRLITSGK-IMHKLP 1631
            ||||||:||:|:|.|||||: ...|:|
Frog  1134 RSGYAFSHQQGYGDLITSGRNFRPKIP 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	41/64 (64%)
		Cation_ATPase	891..985	CDD:289987	63/95 (66%)
		HAD_like	<1261..1324	CDD:304363	50/62 (81%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	127/253 (50%)
XB994119	XP_002940236.3	P-type_ATPase_APLT_Dnf-like	36..980	CDD:319770	586/1246 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I402
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1297	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060