Protein Alignment ATP8B and XB994119

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_002940236.3
• Gene: XB994119 / 100490503
• XenbaseID: XB-GENE-994120
• Length: 1179
• Species: Xenopus tropicalis
• Alignment Length: 1457
• Identity: 663/1457 - (45%)
• Similarity: 849/1457 - (58%)
• Gaps: 327/1457 - (22%)

  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.|||:||||:::|.:|||..|.|||.||::|||||.||.|||||:||.||:.||:|||||.:||
 Frog    15 EKERRLRANDRDYNLKFKYATNAIKTCKYNIFTFLPLNLFEQFQRVANAYFVFLLILQLIPQVSS 79

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            |:..||.:||:.||.::|||||.||..||.||:|||||..:.|.||:....||..:||||:|:|:
 Frog    80 LSWFTTVVPLVLVLAVSAVKDATDDYYRHKSDNQVNNRTVQVLSNGQFTNEKWMNIQVGDIIKLE 144

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERP 385
            ||.||.||.||||:||||||.:|||||||||||||.||.||.|.:||:..:.|..|:||::||.|
 Frog   145 NNNFVTADLLLLSSSEPNGLIYIETAELDGETNLKVKQSLTVTGDLGEDLEQLSRFDGEVVCEAP 209

  Fly   386 NNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGV 450
            ||.|:.|.|||.::|::::|||.|||||||.||||.||:|:|:|||.||||||||||:..|.|.:
 Frog   210 NNKLDTFTGTLTYQGEKYSLDNGKILLRGCTLRNTDWCFGMVIFAGPDTKLMQNSGKSTLKRTSI 274

  Fly   451 DRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFF 515
            |||:|.:::.|.:||.::|.:.|||..|||...|.:||:||||...:      |.|...|.|:|:
 Frog   275 DRLMNILVLWIFVFLAAMCIILAIGNGIWESNQGYYFQVYLPWAEGV------TNAAFSGFLMFW 333

  Fly   516 SYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDK 580
            ||.|:||||||||||||||:||...|:.||||.:||||..:|.|:|||||||||||||:||||||
 Frog   334 SYVIILNTVVPISLYVSVEIIRLGNSYYINWDRKMYYPKKDTPAEARTTTLNEELGQIKYIFSDK 398

  Fly   581 TGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            ||||||||||||||||||.|||||.|. .|..:||.|
 Frog   399 TGTLTQNIMTFNKCSINGNSYGDVYDY-AGNRLEINE---------------------------- 434

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                       |.:|
 Frog   435 -----------HTEK-------------------------------------------------- 438

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775
                                                                             
 Frog   439 ----------------------------------------------------------------- 438

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840
                                                                             
 Frog   439 ----------------------------------------------------------------- 438

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA-ETVDGKL 904
                       ||||.||..:..|.::|..|:::|:..|..:|.||||||||||.|: |...|:|
 Frog   439 -----------VDFSFNPLADPKFSFHDHRLVESVKLGEPATHEFFRLLALCHTAMSEEKKPGEL 492

  Fly   905 EYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            .||||||||.|||:||||||||||||||.:||:..||:|:.|||..||||||.|||||||::..|
 Frog   493 VYQAQSPDEGALVTAARNFGFVFRTRTPETITVVEMGETKVYELQAILDFNNERKRMSVIVKSPD 557

  Fly   970 S-MVLYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            . ::|||||||.::|:.|....||||..|.:|||:|||||||||.||.:.|...|:.||:.|..|
 Frog   558 GRLILYCKGADTIVYELLDQSSEDLKETTTEHLNEFAGEGLRTLVLACKELNPTYFRDWKQRHHE 622

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |:.|:|.||:||..:|||||.:::|:|.:|||||||||||::|..|..|.||||||||||||||.
 Frog   623 ASTSLDDREEKLAKLYEEIEKDLKLLGASAIEDKLQDGVPQTIETLSKANIKIWVLTGDKQETAE 687

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLS 1163
            ||||||.:|.||:.:|||:.|.|.:||.::||..:      .:..|..|       |::|
 Frog   688 NIGYSCNMLQDEMKEVFIIKGCSPDEVLEELRSAR------RKMNPESF-------SETN----- 734

  Fly  1164 VTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDE-KGSEDGGTA 1227
                :.:.::|                      :|:|.::..||         || |||:.
 Frog   735 ----EVNVYLQ----------------------KKSKKSQIIPD---------DELKGSDT---- 760

  Fly  1228 SIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIKRAKNAV 1292
                     |.:::|||||...|...:|.:.|..|..|.|||||||||||||.||:|:|:.|.||
 Frog   761 ---------FGILINGHSLAFALEESMEIELLRTACMCTAVICCRVTPLQKAQVVQLVKKYKKAV 816

  Fly  1293 TLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYRMCKFLR 1357
            |||||||||||||||.||||||||||||:|||||||:|.||||||:|||||||||||.|||:|||
 Frog   817 TLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSDFSFAQFRYLQRLLLVHGRWSYIRMCRFLR 881

  Fly  1358 YFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKNSLEFPR 1422
            |||||||.|||.|.||..|||||||||:|..||::|||.|||||||.:.:|:|||:|:.||:||.
 Frog   882 YFFYKNFTFTLVHFWYGFFCGFSAQTVYDEWFITLYNLVYTSLPVLGMSLFDQDVNDRWSLQFPE 946

  Fly  1423 LYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVVATILIV 1487
            ||.||..:..|||:|||..||||.::||:||.||:|...:.|..:|..:||:.:...:..|.|::
 Frog   947 LYEPGQMNRYFNIKEFIKCVLHGIYSSLILFFIPFGAMYESVREDGRAISDYQSFALMAQTCLLL 1011

  Fly  1488 DNTAQISLYTSYWTVVNHVTIWGSLVWYFVL------DYFYNYVIGG-PYVGSLTQAMKDLTFWV 1545
            ..:.||.|.|:|||.||...||||:..||.:      |..|....|. |::|:....:.....|:
 Frog  1012 VVSVQIGLDTAYWTAVNQFFIWGSMAVYFAITFTMYSDGMYLIFTGSFPFIGTARNTLNQPGVWL 1076

  Fly  1546 TMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR-----ASSDVRRTASSRRGRRSV 1605
            .:.:|.:..|.||:|::|...::.||..||| ||.:::...|     ..:.:|||:|.
 Frog  1077 AIFLTTVLCVLPVVAFRFLRSELFPSTGDKI-QKKIREAKKRPPPPPPKARLRRTSSR------- 1133

  Fly  1606 RSGYAFAHQEGFGRLITSGK-IMHKLP 1631
            ||||||:||:|:|.|||||: ...|:|
 Frog  1134 RSGYAFSHQQGYGDLITSGRNFRPKIP 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	243/390 (62%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	320/573 (56%)
XB994119	XP_002940236.3	P-type_ATPase_APLT_Dnf-like	36..980	CDD:319770	586/1246 (47%)