DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATP8B and atp8b1

DIOPT Version :9

Sequence 1:	NP_731669.2	Gene:	ATP8B / 41469	FlyBaseID:	FBgn0037989	Length:	1726	Species:	Drosophila melanogaster
Sequence 2:	XP_001920510.4	Gene:	atp8b1 / 100148342	ZFINID:	ZDB-GENE-091116-14	Length:	1249	Species:	Danio rerio

Alignment Length:	1542	Identity:	611/1542 - (39%)
Similarity:	806/1542 - (52%)	Gaps:	387/1542 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 PPPNKSDDQELYKQRDPSVTS----ESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEF--N 204
            |..:...|.||..:.|.||..    |::..|::                |....:||||:|:  .
Zfish    22 PYSDDETDAELEDELDQSVDQLPEPETRPAPAV----------------EAGWSVRANDREYCKR 70

  Fly   205 AQF-----------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTP 258
            .:|           :|..|.|||.||::.||||.||.|||:|.||.|||||||||:||.||:|..
Zfish    71 PEFQKKVFLCIKKSRYSGNAIKTYKYNVLTFLPLNLYEQFKRAANLYFLCLLVLQIIPQISTLPW 135

  Fly   259 VTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQ 323
            .||.:||:.||.:||:||..||:.||..|.::||||...|.||:.||.:|..:|||||:||..|.
Zfish   136 YTTLVPLVLVLGITAIKDLVDDLARHRMDKEINNRKCDVLLNGRFVETRWMNLQVGDVVRLHKND 200

  Fly   324 FVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNL 388
            |:.||.:|||||.||.||::||||||||||||.|..|..|.|.......|..||..::||.|||.
Zfish   201 FIPADIMLLSTSNPNSLCYVETAELDGETNLKFKMGLKVTDERLQEEQQLSQFNALVMCEEPNNR 265

  Fly   389 LNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRL 453
            |:||.||:||..|.:|||.:.:|||||.:|||..|:|:|:|||.|||:|:|.|||:||.|.:|:|
Zfish   266 LDKFVGTMIWESQSYALDLDNMLLRGCKVRNTDICHGLVIFAGNDTKIMRNGGKTRFKRTRIDKL 330

  Fly   454 LNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYA 518
            :|:::..|.:.||.:||..|||...|...||..     .|..|...||.   ::..|.|.|:.|.
Zfish   331 MNYMVYTIFVLLVLLCAGLAIGHTYWYESIGSK-----AWYLIDGLDYT---SSYRGFLSFWGYI 387

  Fly   519 IVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGT 583
            |:|||:|||||||||||||..||..||||.:|||...:|.||:|||||||:||||:|||||||||
Zfish   388 IILNTMVPISLYVSVEVIRLGQSKFINWDLQMYYADKDTPAKSRTTTLNEQLGQIEYIFSDKTGT 452

  Fly   584 LTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPI 648
            ||||||.|.||:|:||:||:                           |:...|.
Zfish   453 LTQNIMAFKKCTISGRTYGE---------------------------PTTADGV----------- 479

  Fly   649 ILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDAD 713
                                            .::|..|
Zfish   480 --------------------------------SLDRGKP-------------------------- 486

  Fly   714 AGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMH 778

Zfish   487 ----------------------------------------------------------------- 486

  Fly   779 HSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSP 843

Zfish   487 ----------------------------------------------------------------- 486

  Fly   844 HRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHV-FFRLLALCHTVMAETVDGKLEYQ 907
                    ||||.|.:.:..|::.|..|:..:||.::...: ||:||:||||||.|..:|:|.||
Zfish   487 --------VDFSWNKYADRKFQFEDHFLISCIRSKKDPQVLEFFKLLSLCHTVMVEEKEGELVYQ 543

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV 972
            |.||||.|||:|||||||||.:||.::|||:.|.:.:.|.:|.:||||:.|||||:||:..|..:
Zfish   544 AASPDEGALVTAARNFGFVFLSRTQDTITIQEMDKPQTYTMLALLDFNSDRKRMSIILKFPDGRI 608

  Fly   973 -LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAAL 1036
             |||||||.|||.|| ..|...|..||:.|:.||.|.||||.|..:.::::.::.|..:.|.||:
Zfish   609 RLYCKGADTVIYQRL-SPQSKNKENTQEALDIFANETLRTLCLCYKDISQEEFDRWSRKHQTAAV 672

  Fly  1037 SMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIG 1101
            ||..||::|:.:|||||.::.|:|.||||||||||||::||.|..|.||||||||||:|||.|||
Zfish   673 SMVDRERELDEVYEEIEKDLLLIGATAIEDKLQDGVPETIAKLAKADIKIWVLTGDKKETAENIG 737

  Fly  1102 YSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTM 1166
            ||||||||   |:.|..|   |:|..|||         ||            .:....||.|...
Zfish   738 YSCQLLTD---DMKIHYG---EDVNVQLR---------NR------------QTQRRTDPQSRNK 775

  Fly  1167 TQTSAFMQETNLPPTPPPPPAISVVTFRW------DEKNK------------------DNKGGPD 1207
            .|..:|..|        |.....::|..|      ::|.|                  .:...||
Zfish   776 KQKESFFNE--------PGKNALIITGGWLNEILYEKKKKRRRLRLKKLRLRQNNQQSSSSTAPD 832

  Fly  1208 SAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCR 1272
            |::..:.:..||..||                                  |:|:|.:|.||||||
Zfish   833 SSQPVDDWEKEKRQED----------------------------------FVDMACECSAVICCR 863

  Fly  1273 VTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYL 1337
            |||.|||.||.|:|:.|.||||:||||||||:|||.|.||||||||||:|||:||||:.|||.:|
Zfish   864 VTPKQKANVVSLVKKYKKAVTLSIGDGANDVNMIKTADIGVGISGQEGMQAVMSSDYAFAQFCFL 928

  Fly  1338 ERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPV 1402
            :|||||||||||.||||||||||||||||||.|.|:|.|.||||||.::..||::||:.|:||||
Zfish   929 QRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWFSFFNGFSAQTAYEDWFITLYNVCYSSLPV 993

  Fly  1403 LALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSAN 1467
            |.:|:.:|||:||.||.||:||.||.:..|||.|.|..|:.||.||||::|.||||.:...:..:
Zfish   994 LLVGLLDQDVNDKLSLRFPKLYLPGQQGALFNYRNFFISLFHGIFTSLMIFFIPYGAFLQTMGQD 1058

  Fly  1468 GFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDY----------FY 1522
            |...||:.:...|.|:.||:....||||.|||||.||...:.||:..||.:.:          |.
Zfish  1059 GEAPSDYQSFAVVAASSLIITVNLQISLNTSYWTFVNFFAVLGSIALYFGIMFDIHSAGIHVIFP 1123

  Fly  1523 NYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR 1587
            |..   .:.|:.:.|::....|:|:::||...:.||:..:|....::||:.||: |::.||....
Zfish  1124 NTF---TFTGAASNALRQPYLWLTIILTVGVCLLPVICIQFLYQTIYPSVGDKV-QRNRKKYELE 1184

  Fly  1588 ASSDVR--RTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQ 1632
            ...|.|  |..:.:||.||.||.|||:|..|:..||.||:.:.:.|:
Zfish  1185 DEEDERKKRKPTFQRGGRSRRSAYAFSHSRGYADLIASGRSIRQRPR 1231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	39/77 (51%)
		Cation_ATPase	891..985	CDD:289987	58/94 (62%)
		HAD_like	<1261..1324	CDD:304363	46/62 (74%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	122/256 (48%)
atp8b1	XP_001920510.4	PhoLip_ATPase_N	60..137	CDD:292826	39/76 (51%)
		ATPase-Plipid	86..1176	CDD:273734	573/1405 (41%)
		E1-E2_ATPase	142..>228	CDD:278548	48/85 (56%)
		Cation_ATPase	527..624	CDD:289987	60/97 (62%)
		HAD_like	<872..915	CDD:304363	32/42 (76%)
		PhoLip_ATPase_C	915..1169	CDD:292829	122/256 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	0.586	Domainoid score	I1796
eggNOG	1	0.900	-	-		E2759_KOG0206
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.790