Protein Alignment ATP8B and atp8b1

DIOPT Version :10

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_001920510.4
• Gene: atp8b1 / 100148342
• ZFINID: ZDB-GENE-091116-14
• Length: 1249
• Species: Danio rerio
• Alignment Length: 1542
• Identity: 611/1542 - (39%)
• Similarity: 806/1542 - (52%)
• Gaps: 387/1542 - (25%)

  Fly   146 PPPNKSDDQELYKQRDPSVTS----ESKSVPSLRRLSQIRRRRSSYYFSENERRIRANDKEF--N 204
            |..:...|.||..:.|.||..    |::..|::                |....:||||:|:  .
Zfish    22 PYSDDETDAELEDELDQSVDQLPEPETRPAPAV----------------EAGWSVRANDREYCKR 70

  Fly   205 AQF-----------KYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISSLTP 258
            .:|           :|..|.|||.||::.||||.||.|||:|.||.|||||||||:||.||:|..
Zfish    71 PEFQKKVFLCIKKSRYSGNAIKTYKYNVLTFLPLNLYEQFKRAANLYFLCLLVLQIIPQISTLPW 135

  Fly   259 VTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLDNNQ 323
            .||.:||:.||.:||:||..||:.||..|.::||||...|.||:.||.:|..:|||||:||..|.
Zfish   136 YTTLVPLVLVLGITAIKDLVDDLARHRMDKEINNRKCDVLLNGRFVETRWMNLQVGDVVRLHKND 200

  Fly   324 FVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERPNNL 388
            |:.||.:|||||.||.||::||||||||||||.|..|..|.|.......|..||..::||.|||.
Zfish   201 FIPADIMLLSTSNPNSLCYVETAELDGETNLKFKMGLKVTDERLQEEQQLSQFNALVMCEEPNNR 265

  Fly   389 LNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGVDRL 453
            |:||.||:||..|.:|||.:.:|||||.:|||..|:|:|:|||.|||:|:|.|||:||.|.:|:|
Zfish   266 LDKFVGTMIWESQSYALDLDNMLLRGCKVRNTDICHGLVIFAGNDTKIMRNGGKTRFKRTRIDKL 330

  Fly   454 LNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFFSYA 518
            :|:::..|.:.||.:||..|||...|...||..     .|..|...||.   ::..|.|.|:.|.
Zfish   331 MNYMVYTIFVLLVLLCAGLAIGHTYWYESIGSK-----AWYLIDGLDYT---SSYRGFLSFWGYI 387

  Fly   519 IVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDKTGT 583
            |:|||:|||||||||||||..||..||||.:|||...:|.||:|||||||:||||:|||||||||
Zfish   388 IILNTMVPISLYVSVEVIRLGQSKFINWDLQMYYADKDTPAKSRTTTLNEQLGQIEYIFSDKTGT 452

  Fly   584 LTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAPPPI 648
            ||||||.|.||:|:||:||:                           |:...|.
Zfish   453 LTQNIMAFKKCTISGRTYGE---------------------------PTTADGV----------- 479

  Fly   649 ILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQDAD 713
                                            .::|..|
Zfish   480 --------------------------------SLDRGKP-------------------------- 486

  Fly   714 AGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETHNMH 778
                                                                             
Zfish   487 ----------------------------------------------------------------- 486

  Fly   779 HSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWSSSP 843
                                                                             
Zfish   487 ----------------------------------------------------------------- 486

  Fly   844 HRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHV-FFRLLALCHTVMAETVDGKLEYQ 907
                    ||||.|.:.:..|::.|..|:..:||.::...: ||:||:||||||.|..:|:|.||
Zfish   487 --------VDFSWNKYADRKFQFEDHFLISCIRSKKDPQVLEFFKLLSLCHTVMVEEKEGELVYQ 543

  Fly   908 AQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGDSMV 972
            |.||||.|||:|||||||||.:||.::|||:.|.:.:.|.:|.:||||:.|||||:||:..|..:
Zfish   544 AASPDEGALVTAARNFGFVFLSRTQDTITIQEMDKPQTYTMLALLDFNSDRKRMSIILKFPDGRI 608

  Fly   973 -LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQEAAL 1036
             |||||||.|||.|| ..|...|..||:.|:.||.|.||||.|..:.::::.::.|..:.|.||:
Zfish   609 RLYCKGADTVIYQRL-SPQSKNKENTQEALDIFANETLRTLCLCYKDISQEEFDRWSRKHQTAAV 672

  Fly  1037 SMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAINIG 1101
            ||..||::|:.:|||||.::.|:|.||||||||||||::||.|..|.||||||||||:|||.|||
Zfish   673 SMVDRERELDEVYEEIEKDLLLIGATAIEDKLQDGVPETIAKLAKADIKIWVLTGDKKETAENIG 737

  Fly  1102 YSCQLLTDELADVFIVDGNSVEEVEKQLRQFKESIKIYNRFRPGGFDPFDRLNSDSNMDPLSVTM 1166
            ||||||||   |:.|..|   |:|..|||         ||            .:....||.|...
Zfish   738 YSCQLLTD---DMKIHYG---EDVNVQLR---------NR------------QTQRRTDPQSRNK 775

  Fly  1167 TQTSAFMQETNLPPTPPPPPAISVVTFRW------DEKNK------------------DNKGGPD 1207
            .|..:|..|        |.....::|..|      ::|.|                  .:...||
Zfish   776 KQKESFFNE--------PGKNALIITGGWLNEILYEKKKKRRRLRLKKLRLRQNNQQSSSSTAPD 832

  Fly  1208 SAECNNLFGDEKGSEDGGTASIVVDENTGFALVVNGHSLVHCLSPELENKFLDIASQCKAVICCR 1272
            |::..:.:..||..||                                  |:|:|.:|.||||||
Zfish   833 SSQPVDDWEKEKRQED----------------------------------FVDMACECSAVICCR 863

  Fly  1273 VTPLQKALVVELIKRAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYL 1337
            |||.|||.||.|:|:.|.||||:||||||||:|||.|.||||||||||:|||:||||:.|||.:|
Zfish   864 VTPKQKANVVSLVKKYKKAVTLSIGDGANDVNMIKTADIGVGISGQEGMQAVMSSDYAFAQFCFL 928

  Fly  1338 ERLLLVHGRWSYYRMCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPV 1402
            :|||||||||||.||||||||||||||||||.|.|:|.|.||||||.::..||::||:.|:||||
Zfish   929 QRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWFSFFNGFSAQTAYEDWFITLYNVCYSSLPV 993

  Fly  1403 LALGVFEQDVSDKNSLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSAN 1467
            |.:|:.:|||:||.||.||:||.||.:..|||.|.|..|:.||.||||::|.||||.:...:..:
Zfish   994 LLVGLLDQDVNDKLSLRFPKLYLPGQQGALFNYRNFFISLFHGIFTSLMIFFIPYGAFLQTMGQD 1058

  Fly  1468 GFVVSDHMTLGAVVATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYFVLDY----------FY 1522
            |...||:.:...|.|:.||:....||||.|||||.||...:.||:..||.:.:          |.
Zfish  1059 GEAPSDYQSFAVVAASSLIITVNLQISLNTSYWTFVNFFAVLGSIALYFGIMFDIHSAGIHVIFP 1123

  Fly  1523 NYVIGGPYVGSLTQAMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIRQKSLKKIHSR 1587
            |..   .:.|:.:.|::....|:|:::||...:.||:..:|....::||:.||: |::.||....
Zfish  1124 NTF---TFTGAASNALRQPYLWLTIILTVGVCLLPVICIQFLYQTIYPSVGDKV-QRNRKKYELE 1184

  Fly  1588 ASSDVR--RTASSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQ 1632
            ...|.|  |..:.:||.||.||.|||:|..|:..||.||:.:.:.|:
Zfish  1185 DEEDERKKRKPTFQRGGRSRRSAYAFSHSRGYADLIASGRSIRQRPR 1231

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	Haloacid Dehalogenase-like Hydrolases	211..>602	CDD:473868	220/390 (56%)
		Haloacid Dehalogenase-like Hydrolases	<885..1456	CDD:473868	295/595 (50%)
atp8b1	XP_001920510.4	P-type_ATPase_APLT_Dnf-like	88..1047	CDD:319770	531/1270 (42%)