Protein Alignment ATP8B and atp8b4

DIOPT Version :9

• Sequence 1: NP_731669.2
• Gene: ATP8B / 41469
• FlyBaseID: FBgn0037989
• Length: 1726
• Species: Drosophila melanogaster
• Sequence 2: XP_002936618.2
• Gene: atp8b4 / 100145017
• XenbaseID: XB-GENE-5831431
• Length: 1188
• Species: Xenopus tropicalis
• Alignment Length: 1502
• Identity: 662/1502 - (44%)
• Similarity: 869/1502 - (57%)
• Gaps: 352/1502 - (23%)

  Fly   191 ENERRIRANDKEFNAQFKYHNNYIKTSKYSLFTFLPFNLLEQFQRLANFYFLCLLVLQLIPAISS 255
            |.|||::|||:::|.:|.|.||.||||||::.||||.||.|||||:||.|||.||:|||||.|||
 Frog    10 EEERRVKANDRDYNEKFNYANNAIKTSKYNIVTFLPINLFEQFQRVANAYFLFLLILQLIPEISS 74

  Fly   256 LTPVTTAIPLIGVLTLTAVKDAYDDIQRHISDSQVNNRKSKTLRNGKLVEAKWSEVQVGDVIRLD 320
            |:..||.:||:.|||:||||||.||..||.:|:|||||:|:.|.:|||...||..|:.||:|:|:
 Frog    75 LSWFTTIVPLVLVLTITAVKDATDDFFRHKTDNQVNNRQSQVLLSGKLQNEKWMNVRAGDIIKLE 139

  Fly   321 NNQFVAADTLLLSTSEPNGLCFIETAELDGETNLKAKQCLTETIELGDRHDSLWNFNGEIICERP 385
            |||||.||.||||:|||:|||::||||||||||||.:|.|..|.:||:....|.:|:||:.||.|
 Frog   140 NNQFVVADMLLLSSSEPHGLCYVETAELDGETNLKVRQALPVTADLGESITRLADFDGEVACEPP 204

  Fly   386 NNLLNKFDGTLIWRGQRFALDNEKILLRGCVLRNTQWCYGVVVFAGVDTKLMQNSGKTQFKSTGV 450
            ||.|:||.|||||:..:::|.|.||||||||:|||:||:|:|:|||.|||||||||||:||.|.:
 Frog   205 NNKLDKFTGTLIWKDNKYSLTNSKILLRGCVVRNTEWCFGMVIFAGPDTKLMQNSGKTKFKRTSI 269

  Fly   451 DRLLNFIIIGIVLFLVSICALFAIGCAIWEGLIGQHFQLYLPWEHIIPKDYIPTGATVIGLLVFF 515
            |||:|.:::.|..||:.:..:.|||.:|||..:|..|::||.|..::      ..:...|.|.|:
 Frog   270 DRLMNTLVLWIFGFLICMGIILAIGNSIWEHQVGSRFRIYLYWNEVV------NSSVFSGFLTFW 328

  Fly   516 SYAIVLNTVVPISLYVSVEVIRFVQSFLINWDEEMYYPTTNTYAKARTTTLNEELGQIQYIFSDK 580
            ||.|:|||||||||||||||||...|:.||||.:|:|....|.|:.||||||||||||:||||||
 Frog   329 SYIIILNTVVPISLYVSVEVIRLGHSYFINWDRKMFYSKRGTPAETRTTTLNEELGQIEYIFSDK 393

  Fly   581 TGTLTQNIMTFNKCSINGRSYGDVIDLRTGELVEITEQQTIFQNSNTNNRPSPLSGAIVAPPAAP 645
            |||||||||||||||::|:.||::.| ..|..|.|||
 Frog   394 TGTLTQNIMTFNKCSVSGKVYGELRD-ELGRKVGITE---------------------------- 429

  Fly   646 PPIILVHKAEVHAKKTSMVVTSSGEAQVLPDRPRSDIERSAPPMDASEKRPGLKHVRYSAPSRSQ 710
                                                                             
 Frog   430 ----------------------------------------------------------------- 429

  Fly   711 DADAGRLSPRLDGSGGLSPPVGNEERRISGGFKRSGAGCMQRQLSRTSSCDKVKILHDSQQTETH 775
                                                                             
 Frog   430 ----------------------------------------------------------------- 429

  Fly   776 NMHHSSHNRKRLVKIRFKKAPSTATLGVVISQLEHHLDEEPQSTSTLSTTKHHHHRSKAFATNWS 840
                             |.||
 Frog   430 -----------------KTAP-------------------------------------------- 433

  Fly   841 SSPHRVHALQSVDFSANPHHESDFRWYDRTLLDAVRSDEEHSHVFFRLLALCHTVMA-ETVDGKL 904
                       ||||.||..:..|::||.:|.:|::.:|.:....||||:||||||: |...|:|
 Frog   434 -----------VDFSFNPLADRKFQFYDHSLTEAIKLEEPYVQEVFRLLSLCHTVMSEEKTAGEL 487

  Fly   905 EYQAQSPDEAALVSAARNFGFVFRTRTPNSITIEVMGQTEEYELLNILDFNNVRKRMSVILRRGD 969
            .||.|||||.|||:|||||||:|::|||.:||:|.||:...|:||.||||||:|||||||:|..:
 Frog   488 VYQVQSPDEGALVTAARNFGFIFKSRTPETITVEEMGKVVTYQLLAILDFNNIRKRMSVIVRNPE 552

  Fly   970 SMV-LYCKGADNVIYDRLHGGQEDLKARTQDHLNKFAGEGLRTLALAERRLTEQYYNDWRSRQQE 1033
            ..| |||||||.:::::||...|||...|.||||:||||||||||||.:.|:|.|...|.....|
 Frog   553 GQVKLYCKGADTILFEKLHESSEDLMYITSDHLNEFAGEGLRTLALAYKDLSEDYLKWWLKIHHE 617

  Fly  1034 AALSMDSREQKLNAIYEEIESEMQLVGVTAIEDKLQDGVPKSIANLQNAGIKIWVLTGDKQETAI 1098
            |:.::::||::|.|.||||||.|.|:|.||||||||:||.::|::|..|.||:|:|||||||||:
 Frog   618 ASTALENREERLAAAYEEIESNMMLLGATAIEDKLQEGVIETISSLLLANIKVWILTGDKQETAM 682

  Fly  1099 NIGYSCQLLTDELADVFIVDGNSVEEVEKQLRQFKE-----SIKIYNRFRPGGFDPFDRLNSDSN 1158
            ||||||.:|||::.::|::.|::|.||.::||:.||     |..:||..
 Frog   683 NIGYSCHMLTDDMNEIFVISGHTVMEVREELRKAKECTFGQSRNLYNGH---------------- 731

  Fly  1159 MDPLSVTMTQTSAFMQETNLPPTPPPPPAISVVTFRWDEKNKDNKGGPDSAECNNLFGDEKGSED 1223
                     |.|..||:|.|
 Frog   732 ---------QFSEKMQDTKL--------------------------------------------- 742

  Fly  1224 GGTASIVVDEN-TG-FALVVNGHSLVHCLSPELENKFLDIASQCKAVICCRVTPLQKALVVELIK 1286
                ..|.:|. || :|:|:|||||.|.|..::|.:||:||..||.||||||||||||.||||:|
 Frog   743 ----DTVYEETVTGEYAMVINGHSLAHALEADMEKEFLEIACMCKTVICCRVTPLQKAQVVELVK 803

  Fly  1287 RAKNAVTLAIGDGANDVSMIKAAHIGVGISGQEGLQAVLSSDYSIAQFRYLERLLLVHGRWSYYR 1351
            :.|.||||||||||||:||||:||||||||||||:||||:||||.||||||:|||||||||||:|
 Frog   804 KYKKAVTLAIGDGANDISMIKSAHIGVGISGQEGMQAVLASDYSFAQFRYLQRLLLVHGRWSYFR 868

  Fly  1352 MCKFLRYFFYKNFAFTLCHCWYSLFCGFSAQTVFDPMFISVYNLFYTSLPVLALGVFEQDVSDKN 1416
            |||||.|||||||||||.|.|:..|||||||||:|..||:::|:.||||||||:|:|:|||:|:|
 Frog   869 MCKFLCYFFYKNFAFTLVHFWFGFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGLFDQDVNDQN 933

  Fly  1417 SLEFPRLYTPGLKSELFNIREFIYSVLHGAFTSLVLFLIPYGVYKDGVSANGFVVSDHMTLGAVV 1481
            .:::.:||.||..:.|||.|.|...:.||.:||..||.||:|.:.:....:|..::|:.:....|
 Frog   934 CMDYTKLYEPGQLNLLFNKRRFFICIAHGIYTSFALFFIPFGAFFNTAGEDGKHIADYQSFAVTV 998

  Fly  1482 ATILIVDNTAQISLYTSYWTVVNHVTIWGSLVWYF----------VLDYFYNYVIGGPYVGSLTQ 1536
            ||.|::..:.||.|.|||||.:||..|||||..||          :.|.|.::.   |:||:...
 Frog   999 ATSLVIVVSVQIGLDTSYWTAINHFFIWGSLAVYFSILFAMHGDGIFDIFPSHF---PFVGNARN 1060

  Fly  1537 AMKDLTFWVTMLITVMALVAPVLAYKFYLLDVHPSLSDKIR-----QKSLKKIHSRASSDVRRTA 1596
            ::...:.|:.:.:|.:..|.|||.::|...|:.|:||||:|     :|..|.:.:|... |.||:
 Frog  1061 SLSQKSVWLVIFLTTVICVMPVLTFRFLKADLSPTLSDKVRYLQQAKKRRKPLENRMRR-VHRTS 1124

  Fly  1597 SSRRGRRSVRSGYAFAHQEGFGRLITSGKIMHKLPQDFAFPLGLGTKKTQVLHNNL--NSADGPN 1659
            |.       ||||||:||||:|.||||||.| ::....|   ..|..||.....||  .:|:..|
 Frog  1125 SR-------RSGYAFSHQEGYGELITSGKNM-RVNNPHA---SSGLAKTTSWIENLRKKTAENFN 1178

  Fly  1660 SKGNNVT 1666
            |..::.|
 Frog  1179 SFSSDKT 1185

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ATP8B	NP_731669.2	PhoLip_ATPase_N	195..260	CDD:292826	42/64 (66%)
		Cation_ATPase	891..985	CDD:289987	60/95 (63%)
		HAD_like	<1261..1324	CDD:304363	51/62 (82%)
		PhoLip_ATPase_C	1324..1571	CDD:292829	124/256 (48%)
atp8b4	XP_002936618.2	P-type_ATPase_APLT_Dnf-like	30..973	CDD:319770	572/1253 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	483	1.000	Domainoid score	I402
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1297	1.000	Inparanoid score	I160
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060