DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14736 and Stoml1

DIOPT Version :9

Sequence 1:	NP_001287293.1	Gene:	CG14736 / 41466	FlyBaseID:	FBgn0037986	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	NP_081218.3	Gene:	Stoml1 / 69106	MGIID:	1916356	Length:	399	Species:	Mus musculus

Alignment Length:	328	Identity:	88/328 - (26%)
Similarity:	140/328 - (42%)	Gaps:	70/328 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 WFLVIITFPFSMCCCLTIVPEYSRMIILRLGRLRKGLRGPGLVFILPCIDETHRVDMRTDVTNVR 129
            :.|:::|||.|....|.|||.|.|||:.||||:|.. :|||:|.:||.||...|||:||...||.
Mouse    64 FLLLLLTFPISGWFALKIVPTYERMIVFRLGRIRNP-QGPGMVLLLPFIDSFQRVDLRTRAFNVP 127

  Fly   130 PQDVLTKDSVTITVNAVVYYCIYSPIDSIIQVDDAKQATQLISQVTLRNIVGSKTLNVLLTSRQQ 194
            |..:.:||...::|.|.|.:.|:.|:.|::.|.|...||::.:...:...:..:.|..:...:.:
Mouse   128 PCKLASKDGAVLSVGADVQFRIWDPVLSVMAVKDLNTATRMTAHNAMTKALLRRPLQEIQMEKLK 192

  Fly   195 LSREIQQAVAGITYRWGVRVERVDV-----------------MDITL------------------ 224
            :..::...:..:|..||:.|:||::                 :|.||
Mouse   193 IGDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSLTVPSLDSTLQQLALHLLGGSMNSAVGH 257

  Fly   225 -----PTSLE-----RSLASEAEAVREARAKIILAEGELKASKA-LKEASDVMSENKITLQLRHL 278
                 |.:||     ...||.|.|..|...|..:|||.|.|.:. |.||
Mouse   258 VPSPGPDTLEMINEVEPPASLAGAGPEPSPKQPVAEGLLTALQPFLSEA---------------- 306

  Fly   279 QILSSIASERRVRIIYPIPLEIMEPFMSGKEGQKKDGGGGGGGGKETKKEDVAGG-----SKETR 338
             ::|.:.:..:..:|.|...:.:. |:....||.:.|.|...|..:...|.....     |||.|
Mouse   307 -LVSQVGACYQFNVILPSGTQSIY-FLDLTTGQGRVGHGEPDGIPDVVVEMAEADLQALLSKELR 369

  Fly   339 KEG 341
            ..|
Mouse   370 PLG 372

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14736	NP_001287293.1	PHB	78..225	CDD:214581	51/186 (27%)
CG14736	NP_001287293.1	SPFH_like	100..305	CDD:302763	58/250 (23%)
Stoml1	NP_081218.3	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000250\|UniProtKB:Q9UBI4, ECO:0000255	6..10
		PHB	77..217	CDD:214581	48/140 (34%)
		SPFH_SLP-1	94..224	CDD:259814	38/130 (29%)
		SCP2	305..396	CDD:280250	17/86 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820