Protein Alignment CG14736 and Nphs2

DIOPT Version :10

• Sequence 1: NP_731666.2
• Gene: CG14736 / 41466
• FlyBaseID: FBgn0037986
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: NP_570841.3
• Gene: Nphs2 / 170672
• RGDID: 620461
• Length: 383
• Species: Rattus norvegicus
• Alignment Length: 312
• Identity: 98/312 - (31%)
• Similarity: 176/312 - (56%)
• Gaps: 24/312 - (7%)

  Fly     6 ERKDAATNSEMSKHDQKIPP------KEFKRPSADGGPRPPPSRYIQTSEDNK-DSTFEKVAIGI 63
            ||:.|.......:|  :.|.      .|.:.|..:|      :..:...|..: :...:...:|.
  Rat    44 ERQSAGRTGTREEH--RAPAATVVNVDEVRSPGEEG------TEVVALLESERPEEGIKPSGLGA 100

  Fly    64 C-WFLV-------IITFPFSMCCCLTIVPEYSRMIILRLGRLRKG-LRGPGLVFILPCIDETHRV 119
            | |.||       |:|||||:..|:.:|.||.|:||.|||.|..| .:||||.|.|||:|..|:|
  Rat   101 CEWLLVLSSLIFIIVTFPFSIWFCIKVVQEYERVIIFRLGHLLPGRAKGPGLFFFLPCLDTYHKV 165

  Fly   120 DMRTDVTNVRPQDVLTKDSVTITVNAVVYYCIYSPIDSIIQVDDAKQATQLISQVTLRNIVGSKT 184
            |:|.....:...:|:|||...:.::||.||.:.:....:..:....:|.|.:.|.|::.::..::
  Rat   166 DLRLQTLEIPFHEVVTKDMFIMEIDAVCYYRMENASLLLSSLAHVSKAIQFLVQTTMKRLLAHRS 230

  Fly   185 LNVLLTSRQQLSREIQQAVAGITYRWGVRVERVDVMDITLPTSLERSLASEAEAVREARAKIILA 249
            |..:|..|:.::::::.|:..:|..||::|||.::.|:.||..|:.|||.||||.|:|:.::|.|
  Rat   231 LTEILLERKSIAQDVKVALDSVTCVWGIKVERTEIKDVRLPAGLQHSLAVEAEAQRQAKVRVIAA 295

  Fly   250 EGELKASKALKEASDVMSENKITLQLRHLQILSSIASERRVRIIYPIPLEIM 301
            |||..||::|:.|::::|.....:|||:|..|.|:::::...::.|:|.:::
  Rat   296 EGEKAASESLRMAAEILSGTPAAVQLRYLHTLQSLSTDKPSTVVLPLPFDML 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14736	NP_731666.2	SPFH_like	100..305	CDD:473137	67/203 (33%)
Nphs2	NP_570841.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..73		6/30 (20%)
		SPFH_podocin	122..344	CDD:259809	77/221 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	355..383