DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp5 and CG9861

DIOPT Version :9

Sequence 1:	NP_650149.1	Gene:	ssp5 / 41465	FlyBaseID:	FBgn0037985	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_611778.1	Gene:	CG9861 / 37692	FlyBaseID:	FBgn0034844	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	895	Identity:	241/895 - (26%)
Similarity:	361/895 - (40%)	Gaps:	253/895 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ASWYTNLSDFQVQAVEALAFSIRDDNAEGTVYRTQFCLSRLGVTPMVKTRMLRKLIGICRGSDLA 74
            |.||..:|..|...:..::.|:|||..:||..:....|..||:.|::..:.:.:::.:.|.:.||
  Fly    17 AKWYMGISAKQEATMSTMSESLRDDFEQGTGEKMFKALISLGLQPVISKKKISRIVQLSRNNILA 81

  Fly    75 FLYFLMEACY--KGTGSAYS--ERILMSAITFLDLEMTMRELDKILP-PGVERLN-KKESIAPPV 133
            ||:|:||..|  |.|...||  |::||:||..:|:..|:|.||.:|| |.|::.: :.:|:|
  Fly    82 FLFFVMEGYYKTKQTDGVYSINEQLLMNAIAKIDMLPTIRALDIVLPQPPVKKPDPQTQSLA--- 143

  Fly   134 DYRSMSLPTPLPTKRESDLRKVRSPYFTPLPKPKLPKGGEKFTAKRPCLVVSFPFWPAGERPNYK 198
                 ||.|..|.|:.|.    :||||...|||  .:...:.|||.|..||||.|||....|.|.
  Fly   144 -----SLTTERPQKKPSK----KSPYFLRQPKP--VQRTSRLTAKIPEFVVSFNFWPTNGPPEYG 197

  Fly   199 VNEENRWFAAYRFQPVKRMLFKMVGDIMTDYW--TKIDGTQPAENEAMP------MCEFHKEALR 255
            ..||..|:|.||..|.:|::.|.:.:.:..|:  ..::|.|.||.....      ||..||..:.
  Fly   198 TEEEEPWYALYRLNPGQRLIKKTLSETLERYFKLAAVEGKQDAEETQQSREPEANMCLVHKGQVL 262

  Fly   256 QEQLVKDAAVVKAHKQCLALVDITSRQDALLKKRIVAQLERDIEEVTLRWKRLRERHHTDVMLLE 320
            |.||::|...|||..:||.|:|:......|.|.|||||||.||:.:..|.:.......|.|:.:|
  Fly   263 QAQLLRDELAVKARDRCLELLDVNEPYAKLRKARIVAQLEHDIDVIMARHRNAMHCDQTKVLTIE 327

  Fly   321 DHD-----QM---------------------CSVGKVPTAVQDIRIKYLSQEADIGRLSAKP--- 356
            :.|     ||                     |:|... ||....|.|.|...|:      ||
  Fly   328 NFDCVLCQQMLVSQPWPETKGQIGRALVGEDCTVAHT-TAFDTYRGKRLEGGAE------KPKKK 385

  Fly   357 ------TLGIHVITG--------------------RGNVSRL----------------SKVRVSD 379
                  |.||....|                    :|...||                .|.:|.:
  Fly   386 DGTVARTSGIDTCRGKRLEGGAEKTDSTVPQPPAEKGRGKRLKGGGGKPKKDKKGKKEKKAKVVE 450

  Fly   380 PDDDIPCPTVPVEQKLAKCPPPILGHIKRPRKV-----SITKSKFGDDKQ--------SSCKKPS 431
            |:     |..|.:.|::...||       |||:     .|....|.:..|        |.|:.|.
  Fly   451 PE-----PENPKKPKVSPWKPP-------PRKLVSGPFRIHNIDFNEYTQVCTQVVGPSECELPP 503

  Fly   432 KP--------------------------------GRFFEAPHQHSPFVFKYHAV----------- 453
            .|                                .|||..|..:.|:.||||.|
  Fly   504 APKKSAVSFILAKGKIEGNAHKCDMRMPNNRHVKTRFFRGPRSNKPYQFKYHRVFQSGQPKPFDL 568

  Fly   454 ----------APQDQNPDTKD-----------VIRAQAIRTLKEQSCPSSE-------------- 483
                      |....:.|..|           ||..:|....|.:..|.:|
  Fly   569 SHIMAKSFVKALDQSDGDEADPCYFRELLSEMVIEDEAPPDSKSEGLPETEPEKKSKQDSQPPLE 633

  Fly   484 --------------------DNYNGR--INPRDQVVAAIVECAQNMWFGSLEAHQRRLSSGQSER 526
                                .|::||  :|.:.::|.|:|.||:.:|       |:|....::|
  Fly   634 IFSDLDQTRISDSRETLDRSSNHSGRSHVNYKAEIVDAVVRCAKAVW-------QKRTLIKRAE- 690

  Fly   527 PTTIEVPAKNEPEEICKTNDALDWTKTIKKFDPNNQHLMERLLRDGFSVLRQDPRCVFAAFPDSH 591
               :|...:..|.:.....|.       :.||||:...|::||:||..|||::||.|.|..||:|
  Fly   691 ---MERMGRMTPRKALTHKDT-------ESFDPNDAAQMDKLLKDGMRVLRKEPRYVLACLPDAH 745

  Fly   592 KSFVMVEWIKRRYGKTYCHEEIVDTIEKGLATFVHVENQLNEAPSAKREGFS----AKDTFDDFK 652
            |..|:.||:||||||||..:|:.::|.:....|..|....:...|....|..    :|:.|:.:|
  Fly   746 KLPVLREWVKRRYGKTYSQKELEESIAESSRIFELVTILQSSPASPDLMGIDRLPRSKENFNFYK 810

  Fly   653 RLEALCKKLKTEYRMPLNDKILTLTRICWSALSPHLARSSSMLKTFFAYL 702
            :::......|..|...||.:.|::....|.|:..:|.......||||||:
  Fly   811 QIKNTAALAKQTYHDQLNARYLSIVSSAWYAMGNYLVPGGPPRKTFFAYI 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp5	NP_650149.1	DUF4770	47..218	CDD:292613	67/176 (38%)
ssp5	NP_650149.1	DUF4771	555..709	CDD:292614	54/152 (36%)
CG9861	NP_611778.1	DUF4770	54..218	CDD:292613	67/177 (38%)
CG9861	NP_611778.1	DUF4771	709..867	CDD:292614	54/152 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C9W7
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009976
OrthoInspector	1	1.000	-	-		otm49876
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR41967
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.930