DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ssp5 and CG42820

DIOPT Version :9

Sequence 1:	NP_650149.1	Gene:	ssp5 / 41465	FlyBaseID:	FBgn0037985	Length:	711	Species:	Drosophila melanogaster
Sequence 2:	NP_995659.1	Gene:	CG42820 / 34161	FlyBaseID:	FBgn0262002	Length:	689	Species:	Drosophila melanogaster

Alignment Length:	797	Identity:	209/797 - (26%)
Similarity:	330/797 - (41%)	Gaps:	216/797 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LDKPAPVGASWYTNLSDFQVQAVE----ALAF---SIRDDNAEGTVYRTQFCLSRLGVTPMVKTR 59
            :|...|| ||||..||..|:||.:    ||.|   ||||            ||.||||.|:::.|
  Fly     7 VDLGLPV-ASWYRGLSLDQMQAADELGTALQFDIRSIRD------------CLLRLGVQPLIRNR 58

  Fly    60 MLRKLIGICRGSDLAFLYFLMEACYKGTGSA---YS--ERILMSAITFLDLEMTMRELDKILP-P 118
            .|.::....||..|||||||.:..| .||::   ||  .::|:|||.:|||..|.|.|||:|| |
  Fly    59 ELHRIWRFSRGQKLAFLYFLFQEHY-DTGTSCGKYSVNGQLLLSAIAYLDLPATFRALDKVLPLP 122

  Fly   119 GV-----------ERLNKKESIAP----------------------PVDYRSMS--LPTPLPTKR 148
            ||           .::|...|..|                      |..:|::.  |.:....|:
  Fly   123 GVLCGQTKIQMKNRQINNNRSARPSIIIPNSKTYPQNIDEEMPLDLPATFRALDKVLSSHTTKKK 187

  Fly   149 ESDLRKVRSPYFTPLPKPK-LPKGGEKFTAKRPCLVVSFPFWPAGERPNYKVNEENRWFAAYRFQ 212
            .|..||  |.||...|:|| .|:...:|.:..|.|.:..|    .|..:.| .:|:||:|.::|.
  Fly   188 PSSSRK--SYYFQKQPRPKTTPRRSNQFLSDSPLLKIQIP----NEVGDPK-EDEDRWYADFQFH 245

  Fly   213 PVKRMLFKMVGDIMTDYWTKID--GTQPAENEAMPMCEFHKEALRQEQLVKDAAVVKAHKQCLAL 275
            |::|.:..::...:...:..||  .|.||: :|..:|.||:|...||   :.|.:.:..::.|.:
  Fly   246 PIQRTVKAVIKHELCHLFDHIDEVTTDPAQ-KARDLCGFHEETRTQE---RQAFLQEQRRRYLDM 306

  Fly   276 VDITSRQDALLKKRIVAQLERDIEEVTLRWKRLRERHHTDVMLLEDHDQMCSVGKVPT------- 333
            :|:......|.::||:..:.||::|                .||:..|:..|.| ||.
  Fly   307 IDLEGTAKRLTRERILHHINRDVDE----------------YLLKFGDKGWSPG-VPAFRKAGCV 354

  Fly   334 -------AVQDIRIKYLSQEADIGRLSAKPTLGIHVITGRGNVSRLSKVRVSDPDDDIPCPTVPV 391
                   ...|...:.|..|.:.|||..:          .|.:.||......:||       |..
  Fly   355 ACNELVHVSLDTPPQVLLLEGEWGRLYDR----------SGALMRLCAGEDGEPD-------VLA 402

  Fly   392 EQKLAKCPPPILGHIKRPRKVSITKSKFGDDKQSSCKKPSKPGRFFEAPHQHSPFVFKYHAVAPQ 456
            |::                         .::::.|...|    .:|.:|..|.||.|.|..|..:
  Fly   403 EEE-------------------------QEEEEDSIAIP----EYFTSPGDHKPFAFNYPHVFKR 438

  Fly   457 D--QNPDTKDVIRAQAIRTLKEQSCPSSEDNY----NGRINPRDQVVAAIVECAQNMWFGSLEAH 515
            :  |:.||.||::...:..|..|   .:|...    :|.|. |..:..|:..|.:.::..||
  Fly   439 NSKQSLDTNDVVKKSLMEALGGQ---KNEHRQGVLASGPIR-RSHINEAVSRCVRKIFEKSL--- 496

  Fly   516 QRRLSSGQSERPTTIEVPAKNEPEEICKTNDALDWTKTIKKFDPNNQHLMERLLRDGFSVLRQDP 580
                          :.||....|::   :.:.|.:.:  ::.||::...|:::|.|||.:||:|.
  Fly   497 --------------LAVPTTPTPKD---SIERLVYNR--ERIDPDDDKFMDQMLSDGFEILRRDS 542

  Fly   581 RCVFAAFPDSHKSFVMVEWIKRRYGKTYCHEEIVD--TIEKGLATFVHVENQL------------ 631
            :.|.|:..:.|:...:.|||.|||||.|..:...|  :....:|....:|.:|
  Fly   543 KLVLASLHNGHQIPEVREWICRRYGKRYGPQSHADFESYRHNMAKLSEMEKKLIPLLTNIDPLIV 607

  Fly   632 --NEAPSAKREGFSAKDTFDDFKRLEALCKKLKTEYRMPLNDKILTLTRICWSAL-SPHLARSSS 693
              |..|.|..:....|.            .|.|..:|..:...:|..:|:||.|. |.....||.
  Fly   608 KQNPIPYALHKEIMEKS------------NKFKKSFRDEVLQIVLKQSRLCWQAQHSLRFVNSSR 660

  Fly   694 MLKTFFAYLP--VRYAD 708
            :.:|||.|||  ||..|
  Fly   661 IRRTFFTYLPSSVRSID 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ssp5	NP_650149.1	DUF4770	47..218	CDD:292613	69/212 (33%)
ssp5	NP_650149.1	DUF4771	555..709	CDD:292614	50/173 (29%)
CG42820	NP_995659.1	DUF4770	46..252	CDD:292613	69/213 (32%)
CG42820	NP_995659.1	DUF4771	517..676	CDD:292614	49/170 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C9W7
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009976
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR41967
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.000