DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31358 and STOML1

DIOPT Version :9

Sequence 1:	NP_001287292.1	Gene:	CG31358 / 41462	FlyBaseID:	FBgn0051358	Length:	474	Species:	Drosophila melanogaster
Sequence 2:	NP_004800.2	Gene:	STOML1 / 9399	HGNCID:	14560	Length:	398	Species:	Homo sapiens

Alignment Length:	276	Identity:	82/276 - (29%)
Similarity:	137/276 - (49%)	Gaps:	37/276 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FVSWILVLILLPFSLCCCLTIAYEFHRLVIFRLGRIRSCLGPGLVFLLPCIDSFNTVDIRTDVVN 98
            |:.::|:|:..|.|....|.|...:.|:::|||||||:..|||:|.|||.||||..||:||...|
Human    61 FLGFLLLLVTFPISGWFALKIVPTYERMIVFRLGRIRTPQGPGMVLLLPFIDSFQRVDLRTRAFN 125

  Fly    99 VDPQEMLTKDSVSITVNAVVFYCIYDPINSIIKVDDARDATERISQVTLRNIVGSKGLHELLASR 163
            |.|.::.:||...::|.|.|.:.|:||:.|::.|.|...||...:|..:...:..:.|.|:...:
Human   126 VPPCKLASKDGAVLSVGADVQFRIWDPVLSVMTVKDLNTATRMTAQNAMTKALLKRPLREIQMEK 190

  Fly   164 QQLSLEIQQAVAKITERWGVRVERVDL-MEI------------SLPSSLER-----------SLA 204
            .::|.::...:..:|..||:.|:||:| :|.            :|.|:|::           |:|
Human   191 LKISDQLLLEINDVTRAWGLEVDRVELAVEAVLQPPQDSPAGPNLDSTLQQLALHFLGGSMNSMA 255

  Fly   205 SEAEATREARAKIILAEGEAKASK--ALKECSDVMSENQITLQLRHLQILCSMASERRV------ 261
            ..|.:...|....:::|.|..|.:  |.......::|..:|.    ||...|.|...:|
Human   256 GGAPSPGPADTVEMVSEVEPPAPQVGARSSPKQPLAEGLLTA----LQPFLSEALVSQVGACYQF 316

  Fly   262 NVLFPIPLEIMAPFMD 277
            ||:.|...: .|.|:|
Human   317 NVVLPSGTQ-SAYFLD 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31358	NP_001287292.1	PHB	50..204	CDD:214581	57/177 (32%)
CG31358	NP_001287292.1	SPFH_like	74..276	CDD:302763	65/233 (28%)
STOML1	NP_004800.2	Tyrosine-type lysosomal sorting signal. /evidence=ECO:0000255, ECO:0000269\|PubMed:19696025	6..10
		PHB	77..217	CDD:214581	51/139 (37%)
		SPFH_SLP-1	94..224	CDD:259814	47/129 (36%)
		SCP2	304..395	CDD:280250	8/29 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1062075at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820